DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5348 and ncx-7

DIOPT Version :9

Sequence 1:	NP_611156.3	Gene:	CG5348 / 36877	FlyBaseID:	FBgn0034156	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_499147.3	Gene:	ncx-7 / 176370	WormBaseID:	WBGene00003572	Length:	672	Species:	Caenorhabditis elegans

Alignment Length:	719	Identity:	163/719 - (22%)
Similarity:	288/719 - (40%)	Gaps:	164/719 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PAIDTKTTKSDVFTVKNALDAEF-DNFWKTVSCFAANNFPFEERCEF--------VQKAEDCNSS 57
            |:|....|...:.::|:. ||:: .:|:||.:|   :.:|..|:||.        |....:||.:
Worm     4 PSILFSLTLIFLISIKSC-DAKYRTSFFKTPNC---SIYPDAEKCELNKTWTQEQVCDYVNCNDN 64

  Fly    58 TNVIPYMRLLACD----------LKCINQ-FQEMIFIALFVAFCFQILVLLIYTINVYYSPALKA 111
                      ||:          ::|.:. |..:|.|.:.|.:...:.:::....:.::||::.:
Worm    65 ----------ACEGGGYLLWTQYVECASSTFSRVILIIVGVIYMLVLFIMVSSAADDFFSPSISS 119

  Fly   112 VSRFLHMNEHLAGVTLMAFGNTSADFFANLASVERHVPVFANNLSS---------------ALFV 161
            :...|.::|.:||||.|||||.:.|.|.::|||          |||               .|||
Worm   120 IVAHLRISESVAGVTFMAFGNGAPDVFGSIASV----------LSSPTPKADLALGELFGGGLFV 174

  Fly   162 ITISGGLIFYISPFKMNSYETVRDILFLLLATLLMDYFAYTTNHFALGYEFKFFIVLLVYISYII 226
            .|:....|...|||.:..:.|:||:||.|:|...:.:.....|...|.....|..:.|:|: ..:
Worm   175 TTMVVSTIILTSPFDVEVFSTIRDLLFYLVALSFLAFCFVFYNRVTLWMPLTFLGLYLLYV-ITV 238

  Fly   227 INVADVY-----LLQKTIASTRTKMQKLLDEKQT----------PEIALKLQDLERKLEYYSQDT 276
            |....|:     .|||..::...|..|.|..:::          |||  ::.|.|......|..|
Worm   239 IGAQAVHNRKRKALQKQNSTKSRKSIKSLRSRKSIHSVAPMPVIPEI--EVHDQEAPFPEISVVT 301

  Fly   277 ------RVEILEKSSSISITRIRYTTMRMIRNPRVSVNRRYTRNMKLDYTQSKNQGIFR------ 329
                  :..:.||:.         ||.|..:.....||.....|....|....:.||.|
Worm   302 GAIDKLKEHMAEKAQ---------TTRRYTKRASFMVNGDGNLNGLHPYATHNHLGISRRESELS 357

  Fly   330 ----DFF------------------LALRPIKCQAWKQAELL----------------------N 350
                :|.                  |...|::.::|:..::|                      :
Worm   358 DEDEEFVVIHGHVFQGHEARSRAASLVPEPMQIKSWRSKDILKDLAEHLDPRPEAEDWEEMNIFS 422

  Fly   351 RVLLLIRAPAVVICTLYIPLVDYEMEKHGWNKLLNAINVVVNPA---LSISIFLSFMHRKGNFLW 412
            :|:..|.....::..|.|||     .:..|:|.|..::....||   .||..||.........||
Worm   423 KVMAYINVVPNLLFKLTIPL-----NEMSWSKPLTLLHAFTCPAFLLFSIQFFLETPFSGSPGLW 482

  Fly   413 YISLQNTLIYG-ASSFVLTVPFAVFILFHARTDVPPSYH-WVFTIMNLTGSMFLIFLCATEIDTV 475
                    :|| |.|.||    |:.|:......|.|.|: .:::......|:..|:|.::|:..|
Worm   483 --------VYGLAVSIVL----AILIMVFTELSVQPKYYKEIYSYSGFIMSIAWIYLISSEVVNV 535

  Fly   476 LEVIGNILSIDDNYMGATVKAFTGNLGTLFANTAVAIHGYPKMAFASAIGGSFFTIVVTGNTVAY 540
            :.::|.:..:....:|.|:.|::.::|.|.|:.:|...|||:||.|:||||..|.:::.......
Worm   536 VTMLGVVSRVSHEVLGLTILAWSNSIGDLIADVSVVKQGYPRMAMAAAIGGPLFNLLMGFGLPFT 600

  Fly   541 VRSLVGNRSEHHMEEYGEIAFIFLNMALFTILLWSTTLGFFARRSMGLYSIGLYVVYLLFVTLVH 605
            :..|.|......:.....:..:||.::|...|:......|..:|......|.:|:.:::||.|..
Worm   601 IAKLQGKYISMTINPTYRLLILFLAISLLATLIGIPVQKFRLQRPHAAVLISIYIAFIVFVILSE 665

  Fly   606 EEVI 609
            ..|:
Worm   666 TGVL 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5348	NP_611156.3	Na_Ca_ex	86..>186	CDD:279963	32/114 (28%)
CG5348	NP_611156.3	Na_Ca_ex	458..603	CDD:279963	36/144 (25%)
ncx-7	NP_499147.3	PLN03151	56..671	CDD:215604	148/663 (22%)
		Na_Ca_ex	96..240	CDD:279963	41/154 (27%)
		Na_Ca_ex	513..663	CDD:279963	36/149 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165713
Domainoid	1	1.000	75	1.000	Domainoid score	I5893
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41602
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4675
OMA	1	1.010	-	-		QHG57812
OrthoDB	1	1.010	-	-		D257493at33208
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		mtm4752
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	O	PTHR12266
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X612
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.670