DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5348 and SLC24A4

DIOPT Version :9

Sequence 1:	NP_611156.3	Gene:	CG5348 / 36877	FlyBaseID:	FBgn0034156	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_011534738.1	Gene:	SLC24A4 / 123041	HGNCID:	10978	Length:	669	Species:	Homo sapiens

Alignment Length:	667	Identity:	124/667 - (18%)
Similarity:	237/667 - (35%)	Gaps:	219/667 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 NSSTNVIP----YMRLLA----------CDLKCINQFQEMIF---------IALFVAFCFQILVL 96
            ::|..|:|    ..:|:|          |....|::|...:|         :.|.:.....:...
Human    96 SASKRVLPDTWRNRKLMAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYA 160

  Fly    97 LIYTINVYYSPALKAVSRFLHMNEHLAGVTLMAFGNTSADFFANLASVERHVPVFANN------- 154
            |....:.::.|:|:.:...||::|.:||.|.||.|:::.:.||::      :.||..:
Human   161 LAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASV------IGVFITHGDVGVGT 219

  Fly   155 -LSSALF----VITISGGLIFYISPFKMNSYETVRDILFLLLATLLMDYFAYTTNHFALGYEFKF 214
             :.||:|    :|.:.|  :|.....::..:...||.::..::.:::..|.|  :...:.:|  .
Human   220 IVGSAVFNILCIIGVCG--LFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIY--DEQIVWWE--G 278

  Fly   215 FIVLLVYISYIII---NV---ADVYLLQKTIASTRTKMQKL----------LDEKQTPEIALKLQ 263
            .:::::|:.||:|   ||   |...:.||:||:......:|          .|:...|    .|.
Human   279 LVLIILYVFYILIMKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVP----LLG 339

  Fly   264 DLERKLEYYSQDTRV--EILEKS--------SSISI---------TRIRYTTMRMIRNPRVSV-- 307
            .::.|.:|......:  ||:..|        :.:.|         ||:|..: |:|.|.|..:
Human   340 QVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMAS-RIIINERQRLIN 403

  Fly   308 -----------NRRYTR----NMKLDYTQSKNQG----------------IFRDFFLALRPIKCQ 341
                       |.|:..    |:.::..:...|.                :..||   |.|....
Human   404 SANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADF---LSPFSVP 465

  Fly   342 AWKQAELLNRVLLLIRAPAVVICTLYIPLVDYEMEKHGWNKLLNAINVVVNPALSISIFLSFMHR 406
            ..:.    ::|..:...|.:.:..:.||    ...|..|.|..  :...:...|.|::|
Human   466 EARG----DKVKWVFTWPLIFLLCVTIP----NCSKPRWEKFF--MVTFITATLWIAVF------ 514

  Fly   407 KGNFLWYISLQNTLIYGASSFVLTVPFAVFILFHARTDVPPSYHWVFTIMNLTGSMFLIFLCATE 471
                               |:::.                    |:.||
Human   515 -------------------SYIMV--------------------WLVTI---------------- 524

  Fly   472 IDTVLEVIGNILSIDDNYMGATVKAFTGNLGTLFANTAVAIHGYPKMAFASAIGGSFFTIVVTGN 536
                   ||..|.|.|..||.|..|...::....|:..||..|...||.::.||.:.|.|:|...
Human   525 -------IGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLG 582

  Fly   537 TVAYVRSLVGNRSEHHMEEYGEIAFIFLNMALFTILLW-----STTLGFFAR-----RSMGLYSI 591
            ....::::|.|        ||....|.....:::::|.     .|.||....     |.:|:|.:
Human   583 VPWGLQTMVVN--------YGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVL 639

  Fly   592 GLYVVYLLFVTLVHEEV 608
            .||.::|.|..::...|
Human   640 VLYAIFLCFSIMIEFNV 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5348	NP_611156.3	Na_Ca_ex	86..>186	CDD:279963	23/111 (21%)
CG5348	NP_611156.3	Na_Ca_ex	458..603	CDD:279963	36/154 (23%)
SLC24A4	XP_011534738.1	TIGR00367	149..645	CDD:273039	112/601 (19%)
		Na_Ca_ex	150..292	CDD:279963	30/153 (20%)
		Na_Ca_ex	499..651	CDD:279963	43/229 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810