DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-104 and AT4G38950

DIOPT Version :9

Sequence 1:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster
Sequence 2:	NP_001119143.1	Gene:	AT4G38950 / 830050	AraportID:	AT4G38950	Length:	836	Species:	Arabidopsis thaliana

Alignment Length:	912	Identity:	239/912 - (26%)
Similarity:	379/912 - (41%)	Gaps:	250/912 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNT----SDSVKRFNFDYSYWSHDHHD 64
            :.|.||:||.|.:|||.......|....||.:..     ||    |:....::||..|      .
plant    14 ILVLVRLRPLNQKEIAANEAADWECINDTTILYR-----NTLREGSNFPSAYSFDKVY------R 67

  Fly    65 ADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLFTR 129
            .:..|: .||:|..:|:......|.|..|||||||.:||:|||        .||......|:|..
plant    68 GECPTR-QVYEDGTKEIALSVVKGINCSIFAYGQTSSGKTYTM--------TGITEFAVADIFDY 123

  Fly   130 IQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIHD 194
            |  .:.::..:||:.|.:|||.|.:||||: .:..:||:|:.|..|..||..::..:.|:..:.:
plant   124 I--FQHEERAFSVKFSAIEIYNEAIRDLLS-SDGTSLRLRDDPEKGTVVEKATEETLRDWNHLKE 185

  Fly   195 LIDEGNKARTVAATNMNETSSRSHAVFTIFF-TQRRHDLMTNLTTEKVSKISLVDLAGSERADST 258
            |:......|.:..|::||.|||||.:..:.. :..|..|....:|..::.::.:||||||||...
plant   186 LLSICEAQRKIGETSLNERSSRSHQMIRLTVESSAREFLGKENSTTLMASVNFIDLAGSERASQA 250

  Fly   259 GAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGNSKTA 323
            .:.|||||||.:||:||.|||.||        :|.:..:...|.:|||.||.:|:..||||::||
plant   251 MSAGTRLKEGCHINRSLLTLGTVI--------RKLSKGRQGHINFRDSKLTRILQPCLGGNARTA 307

  Fly   324 MIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAK-LIRELKEEIQKLRDLLKAEGIEV 387
            :|..:|||..:.:.|.:||.:|..||::..||.:|...:.| |:::|:.|:.:|
plant   308 IICTLSPARSHVELTKNTLLFACCAKEVTTKARINVVMSDKALLKQLQRELARL----------- 361

  Fly   388 QEEDELTKSTVIKSPTKSRNRN---GSTTEMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQRE 449
                    .|.:::|..|...|   ..|......|:|..||.||||.:..:....|.|:
plant   362 --------ETELRNPASSPASNCDCAMTVRKKDLQIQKMEKEIAELRKQRDLAQSRLED------ 412

  Fly   450 AVFAEMGVAVKEDGITVGVFSPKKTPHLVNLN---EDPNLSEC-------LLYYIKEG------L 498
              |..|        |...|.|...|||..|..   ||.::||.       ...:|.:|      :
plant   413 --FMRM--------IEHNVASKPGTPHFGNHTDKWEDGSVSETSGVVDSDRRSFISDGMSTPLSI 467

  Fly   499 TRLGTH----EANVPQDIQLSGSHILKEHC----TFENKNSTVTLLPHK---------------D 540
            :|...|    :.::.:|:......:.:|:|    ..|.:.| ||:..:|               |
plant   468 SRAYVHSHSDDDDLDEDLPRRSEDLSEEYCREVQCIETEES-VTVYNNKKDKRAEPENVLGCGED 531

  Fly   541 AIIYVNGRKLVE--------------------PEVLKTGSRVILGK--NHVFRFTNPEQARELRD 583
            |    ||...|.                    ||.:.||   .||:  :|...|.:.|....:
plant   532 A----NGETSVSQNVRVRSWNRRETVSGPSTPPENIGTG---FLGRPESHKIAFPDLEFGSTV-- 587

  Fly   584 KIETENEAENEV--EKTDTQQVDWNFAQCELLEKQGI--------DLKAEMKKR---LDNLEEQY 635
               :.|::.:..  :.|.||.:     :..|.|:.||        .|| ||.||   :.|.|:..
plant   588 ---SRNDSMSSCGSDSTGTQSI-----RTPLGEEGGITSIRTFVEGLK-EMAKRQGEVSNAEDSG 643

  Fly   636 KREK---LQA-DQQFEEQR----------------KTY--------EARIDALQKQVE------- 665
            |..:   |.: |::||.||                :||        ||  |::...||
plant   644 KMRRDIGLDSMDREFERQRQEILELWQTCNISLVHRTYFYLLFKGDEA--DSIYIGVELRRLLFM 706

  Fly   666 -----------EQSMTMSMYSSYSPEDFHQEEDVYTNPMYESCWTAREAGLAAWAFRKWRYHQF- 718
                       |...|:::.|  |.::.|:|..:.:. :....::..|        ||..||:|
plant   707 KDSFSQGNQALEGGETLTLAS--SRKELHRERKMLSK-LVGKRFSGEE--------RKRIYHKFG 760

  Fly   719 ---------TSLRDDLWGNAIFLKEANAISVELKKKVQF--------QFTLLTDTLYSPLPPELA 766
                     ..|.::||.|...:.:....:..:.|.|:|        :...||.|     ||...
plant   761 IAINSKRRRLQLVNELWSNPKDMTQVMESADVVAKLVRFAEQGRAMKEMFGLTFT-----PPSFL 820

  Fly   767 ST 768
            :|
plant   821 TT 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	124/358 (35%)
		KISc	3..358	CDD:214526	124/358 (35%)
		Kinesin_assoc	355..498	CDD:292801	37/162 (23%)
		FHA	475..574	CDD:238017	32/159 (20%)
		KIF1B	878..923	CDD:289208
		DUF3694	1246..1347	CDD:289256
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
		PH	1607..1700	CDD:278594
AT4G38950	NP_001119143.1	KISc_CENP_E	13..335	CDD:276825	122/351 (35%)
		DUF4175	<349..>419	CDD:372724	22/104 (21%)
		DUF3490	658..816	CDD:371840	33/175 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910