DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unc-104 and AT4G24170

DIOPT Version :9

Sequence 1:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster
Sequence 2:	NP_001320052.1	Gene:	AT4G24170 / 828517	AraportID:	AT4G24170	Length:	1004	Species:	Arabidopsis thaliana

Alignment Length:	1052	Identity:	252/1052 - (23%)
Similarity:	412/1052 - (39%)	Gaps:	265/1052 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VKVAVRVRPFNSREIARESKCIIEMAGATTAITN----PKVPPNTSDSVKRFNFDYSYWSHDHHD 64
            :.|:|||||.|.:|..|..:|..|....||.|..    |.....|.|.|  |.|:
plant     7 ILVSVRVRPLNEKEKTRNDRCDWECINDTTIICKFHNLPDKSSYTFDKV--FGFE---------- 59

  Fly    65 ADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLFTR 129
               .....||.|..:|:......|.|..|||||||.:||:|||        .||......|:|..
plant    60 ---CPTKQVYDDGAKEVALCVLSGINSSIFAYGQTSSGKTYTM--------SGITEFAMDDIFAY 113

  Fly   130 IQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIHD 194
            | |....:.|::::.|.||||.|.|||||...:...||:.:.|..|..||.|.:..:.|...:.:
plant   114 I-DKHKQERKFTLKFSAMEIYNEAVRDLLCEDSSTPLRLLDDPERGTVVEKLREETLRDRSHLEE 177

  Fly   195 LIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERADSTG 259
            |:......|.:..|::||.|||||.:..:.............:....:.:..|||||||||..|.
plant   178 LLSICETQRKIGETSLNEISSRSHQILRLTIESSSQQFSPESSATLAASVCFVDLAGSERASQTL 242

  Fly   260 AKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGNSKTAM 324
            :.|:|||||.:||:||.|||.||..|    ||.||    ..||||||.||.:|:.:||||::||:
plant   243 SAGSRLKEGCHINRSLLTLGTVIRKL----SKGKN----GHIPYRDSKLTRILQNSLGGNARTAI 299

  Fly   325 IAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAK-LIRELKEEIQKLRDLLKAEGIEVQ 388
            |..:|||..:.:::.:||.:|..||::...|.||...:.| |:::|:.|:.::.:.||..|
plant   300 ICTMSPARSHLEQSRNTLLFATCAKEVTTNAQVNLVVSEKALVKQLQRELARMENELKNLG---- 360

  Fly   389 EEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQREAVFA 453
                         |..:    .||::.....|:..|:|||::.|       :..|::.||:..
plant   361 -------------PASA----SSTSDFYALMLKQKEELIAKMEE-------QIHELKWQRDVA-- 399

  Fly   454 EMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLSGSH 518
                                                                       |....:
plant   400 -----------------------------------------------------------QSRVEN 405

  Fly   519 ILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQARELRD 583
            :||.  |.|.::|:.::...:..|.| :.....||.:|..     |||::::   :|::...|.|
plant   406 LLKS--TAEERSSSSSMDSRRRRISY-DSTDFDEPRMLNN-----LGKSNLY---SPDEDGFLLD 459

  Fly   584 KIETENEAEN------EVEKTDTQQVDWNFAQCELLE-KQGIDLKAEMKKRLDNLEEQYKREKLQ 641
            ....:....|      |:.::.||:.:....:...:| ..|...:.:::..||::.|:
plant   460 DTTPQFPGHNLHDKWEEMAQSTTQEPEDACKEVRCIEVNSGEAERVQIQDSLDDIVEK------- 517

  Fly   642 ADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNPMYESCW-TAREAGL 705
                 :|..:.||::.|.....::...|.:|:|:  .||   .|:.|....:.|... |.:....
plant   518 -----KEYEQNYESQKDDADSSIKNIDMELSLYT--KPE---AEDGVSVKKLIEDVQETEQSVEK 572

  Fly   706 AAWAFRKWRYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQFQFTLLTDTLYSPLPPELASTVA 770
            ...:.:|....|:.| ||              :|.::.|.:                ||....|.
plant   573 QKQSPKKEEMEQYLS-RD--------------MSEQVTKSL----------------PEEEQCVQ 606

  Fly   771 PVHQEDEFGAPPV---------SKTLVAVEVTDTKNGATHHWSLEKLRYRLELMRQIYNVESPPS 826
            .....|:..|..|         .:|..:||..|||...:......|....::...|:|  :|||.
plant   607 EYGAYDKLEAQDVLTINKLEESQQTEQSVEKEDTKKNLSSKKEDLKQNLSMDQSEQLY--KSPPE 669

  Fly   827 SMLFDTSGMEALSGWISPPSQHPGQQAQLLPLEPPVESERGRLTLANLIPSRQRLELMREMYHNE 891
                |...:|...|.....:.:...:.::..::..:|          ...|.|..|
plant   670 ----DEKCVEVYEGSDKDDNTYEALKKKVKEMQKTIE----------YFMSIQSAE--------- 711

  Fly   892 AEMSPTSPDYNV--ESLTGGDPFYDRFPWFRMVGRSFIYLSNLLYPVPLVHKVAIVNERGDVRGY 954
               ...||.:|:  ::|:.|:       :|:| .||.....|||:    ....|....||.:...
plant   712 ---EKQSPSFNIIDDTLSPGE-------YFKM-RRSRSCRENLLF----TKAAAAAASRGFIFET 761

  Fly   955 LRIA----VQPVLDEESI-DFNNGVKQSARLVFNEDDAKPKYRAL----NEKDDVQRYIDNGGLD 1010
            ...:    :...:|.:|| |.:.....|:   |:|..|..:.|.:    ...||.         |
plant   762 TNTSFDSDITVSMDAQSIKDSDTETSSSS---FHEFMAGLRERTMQHHSTHSDDT---------D 814

  Fly  1011 SKLEELEDVDSG 1022
            :|..:.|:.|.|
plant   815 TKTMKPENTDDG 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	129/357 (36%)
		KISc	3..358	CDD:214526	129/357 (36%)
		Kinesin_assoc	355..498	CDD:292801	22/143 (15%)
		FHA	475..574	CDD:238017	14/98 (14%)
		KIF1B	878..923	CDD:289208	9/46 (20%)
		DUF3694	1246..1347	CDD:289256
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
		PH	1607..1700	CDD:278594
AT4G24170	NP_001320052.1	KISc_CENP_E	6..326	CDD:276825	128/350 (37%)
		PTZ00121	<473..724	CDD:173412	56/326 (17%)
		DUF3490	831..980	CDD:403272
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910