DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-104 and AT2G21300

DIOPT Version :9

Sequence 1:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster
Sequence 2:	NP_001031385.1	Gene:	AT2G21300 / 816669	AraportID:	AT2G21300	Length:	862	Species:	Arabidopsis thaliana

Alignment Length:	953	Identity:	247/953 - (25%)
Similarity:	396/953 - (41%)	Gaps:	212/953 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VKVAVRVRPFNSREI----ARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSHDHHD 64
            :.|.||:||.|.:||    |.:.:||.:   .|....|.....:|..|.  ::||..|      .
plant    25 ILVLVRLRPLNEKEILANEAADWECIND---TTVLYRNTLREGSTFPSA--YSFDRVY------R 78

  Fly    65 ADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLFTR 129
            .:..|: .||:|..:|:......|.|..|||||||.:||:|||        .||......|:|..
plant    79 GECPTR-QVYEDGPKEVALSVVKGINSSIFAYGQTSSGKTYTM--------SGITEFAVADIFDY 134

  Fly   130 IQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIHD 194
            |  .:.:|..:.|:.|.:|||.|.:||||:| :...||:|:.|..|..||..::..:.|:..:.:
plant   135 I--FKHEDRAFVVKFSAIEIYNEAIRDLLSP-DSTPLRLRDDPEKGAAVEKATEETLRDWNHLKE 196

  Fly   195 LIDEGNKARTVAATNMNETSSRSHAVFTIFF-TQRRHDLMTNLTTEKVSKISLVDLAGSERADST 258
            ||......|.:..|::||.|||||.:..:.. :..|..|....:|..::.::.:||||||||...
plant   197 LISVCEAQRKIGETSLNERSSRSHQIIKLTVESSAREFLGKENSTTLMASVNFIDLAGSERASQA 261

  Fly   259 GAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGNSKTA 323
            .:.|.|||||.:||:||.|||.||        :|.:..:...|.||||.||.:|:..||||::||
plant   262 LSAGARLKEGCHINRSLLTLGTVI--------RKLSNGRQGHINYRDSKLTRILQPCLGGNARTA 318

  Fly   324 MIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAK-LIRELKEEIQKLRDLLKAEGIEV 387
            ::..:|||..:.::|.:||.:|..||::..||.:|...:.| |:::|:.|:.:|
plant   319 IVCTLSPARSHVEQTRNTLLFACCAKEVTTKAQINVVMSDKALVKQLQRELARL----------- 372

  Fly   388 QEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQREAVF 452
              |.||..    .:|..|....|.|......|:|..||.:||:.:..:....|.|:        |
plant   373 --ESELRN----PAPATSSCDCGVTLRKKDLQIQKMEKQLAEMTKQRDIAQSRLED--------F 423

  Fly   453 AEMGVAVKEDGITVGVFSPKKTPHLVNLN---EDPNLSEC-------LLYYIKEGL-TRLGTHEA 506
            .:|   |:.|     ..|...|||..|..   ||.::||.       ...:|.:|. |.|.|..|
plant   424 MKM---VEHD-----ASSKAGTPHFRNRTNKWEDGSVSEISGVVDPDRTSFISDGTSTPLSTARA 480

  Fly   507 NV----PQDI--QLSGSHI---LKEHC-----------------TFENKNSTVTLLPHK------ 539
            :|    ..|:  ::|..|.   .:|:|                 ..|.:....|||.|.
plant   481 HVRSHSDDDLEEEMSPRHSGDQSEEYCKEVQCIEMEESTRDINNDSEERTDAETLLGHNAEANGE 545

  Fly   540 ---------DAIIYVNGRK-----------LVEPEVLKTGSRVILGK--NHVFRFTNPE---QAR 579
                     .::..|..||           ...|:.|:|..|   |:  .|.|.|.:.|   ..:
plant   546 TGSAQHRIPSSVRSVRRRKSWSRGDTMTGTSTPPDALETDYR---GRPEGHGFAFPDLEFGSGGK 607

  Fly   580 ELR-DKIETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEMKKRLDNLEEQYKREKLQAD 643
            .|| |.:.:......|.....|..|.         |:.||   ..::..::.|     :|.:...
plant   608 LLRNDSMTSRGSDSTEAHSIGTPLVG---------EEGGI---TSIRSFVEGL-----KEMVSDP 655

  Fly   644 QQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNPMYESCWTAREAGLAAW 708
            :...:.||  :..:||::   ||.|.||:.:|    |:|.::               ||..|..|
plant   656 ENSGKMRK--DIGVDAME---EEVSGTMTNWS----EEFERQ---------------REQILGLW 696

  Fly   709 -------AFRKWRYHQFTSLRDDLWGNAIFLKEANAISVELKKK--VQFQFTLLTDTLYSPLPPE 764
                   ..|.:.:..||..:.|    :|:      |.|||::.  ::..|:.............
plant   697 QTCHVSLVHRTYFFLLFTGDQAD----SIY------IGVELRRLSFMKESFSQGNHAFERGQTLT 751

  Fly   765 LASTVAPVHQEDEFGAPPVSKTLVAVEVTD--TKNGATHHWSLEKLRYRLELMRQIYNVESPPSS 827
            :||::..:|:|....:..|.|.....|...  .|.|.    ::...|.||:|..|::   |.|:.
plant   752 IASSLKALHRERRMLSKLVGKRFTGEERKRLYQKFGI----AVNSKRRRLQLANQLW---SKPND 809

  Fly   828 MLFDTSGMEALSGWISPPSQHPGQQAQL-LPLEPPVESERGRL 869
            :.........::..:....|....:... |...||:.:.|..|
plant   810 ITHAVESAAVVAKLVRFVEQGRAMKEMFGLSFTPPLPTTRRSL 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	125/358 (35%)
		KISc	3..358	CDD:214526	125/358 (35%)
		Kinesin_assoc	355..498	CDD:292801	36/153 (24%)
		FHA	475..574	CDD:238017	35/163 (21%)
		KIF1B	878..923	CDD:289208
		DUF3694	1246..1347	CDD:289256
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
		PH	1607..1700	CDD:278594
AT2G21300	NP_001031385.1	KISc_CENP_E	24..346	CDD:276825	123/351 (35%)
		Kinesin	30..346	CDD:278646	121/346 (35%)
		DUF3490	685..844	CDD:288820	33/190 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910