Protein Alignment unc-104 and Kif18b

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: NP_932063.2
• Gene: Kif18b / 70218
• MGIID: 2446979
• Length: 834
• Species: Mus musculus
• Alignment Length: 777
• Identity: 212/777 - (27%)
• Similarity: 341/777 - (43%)
• Gaps: 206/777 - (26%)

  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSHDHHD-- 64
            |.|:|.|||||...:|:..:.:.:|::......:.:|:........:|        ||..|:.
Mouse     8 SVVRVVVRVRPPTPKELESQRRPVIQVVDERMLVFDPEECDGGFPGLK--------WSGSHNGPK 64

  Fly    65 --------------ADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQ 115
                          .:.:||..|::.....:|.....|||..:||||.|||||::||:||  |.:
Mouse    65 KKGKDLTFVFDRVFGEMATQEDVFQHTTHNILDSFLQGYNCSVFAYGATGAGKTHTMLGR--EGE 127

  Fly   116 EGIIPMICKDLFTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVED 180
            .||:.:...:|:.|: :...::.::.|.:||:|:|.|::.|||.|  ||.|.:||.|..|..|..
Mouse   128 PGIMYLTTMELYRRL-EARQEEKQFEVLISYLEVYNEQIHDLLEP--KGPLTIREDPDKGVVVPG 189

  Fly   181 LSKLAVTDYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTE-KVSKI 244
            ||.......:.:.:::..||.:||...|:.|.|||||||:|.||..|:  |.:..||.. :|:|:
Mouse   190 LSFHQPASAEQLLEMLTRGNCSRTQHPTDANATSSRSHAIFQIFVKQQ--DRVPGLTQALRVAKM 252

  Fly   245 SLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALT 309
            ||:||||||||.||.|||.||:||||||:||..|..|::|||:...:|.:      :|||||.||
Mouse   253 SLIDLAGSERASSTHAKGERLREGANINRSLLALINVLNALADAKGRKSH------VPYRDSKLT 311

  Fly   310 WLLRENLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQI---VCKAVVNEDAN----AKLIR 367
            .||::::|||.:|.|||||||:.:.|::|.:||:||||||:|   :...|::.|.:    |.:.:
Mouse   312 RLLKDSIGGNCRTVMIAAISPSSLTYEDTYNTLKYADRAKEIRLTLKSNVISVDHHISQYATICQ 376

  Fly   368 ELKEEIQKLRDLLK-----AEGIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLI 427
            :|:.|:..||:.|:     |:.::.|...:....::.:|.:.|..:.|.:::.:..:..|..:.:
Mouse   377 QLQAEVAFLREKLQMYEAGAQALQQQCSPQPPTLSIPQSLSSSSLQPGPSSQSSTLECHAKNETL 441

  Fly   428 --------AELNETWEEKLKRTEEIRVQRE----------------AVFAEMGVAVKEDGITVGV 468
                    |:..|..||.....|:....::                :|.|:.|         .|.
Mouse   442 QEESLGSDAQGQEIVEESASEQEQCPQDKQCPTQKPEPNLPGSPSPSVQAKPG---------TGQ 497

  Fly   469 FSPKK------------------------------TPHLVNLNEDPNLSECLLYYIKEGLTRLGT 503
            .||:|                              ||.::  :|...|.:.:|   :|.:    .
Mouse   498 HSPQKQDADHSKQLALQVLRLAQRQYSLLQAANLLTPDMI--SEFETLQQLVL---EESV----D 553

  Fly   504 HEANVPQDIQLSGSHILKEHCTFENKNS------TVTLLPHKDAIIYVNG--------------- 547
            |.|..|:...|:....|.:....|:|:|      |.|:....:.:.:..|
Mouse   554 HRAESPRSPALARGDPLAQALCSESKSSGYCGPVTRTMAKQLNGLTHTLGAPLAPDCTSDKTFQK 618

  Fly   548 ------RKLVEPE--------------------VLKTG--------------------------- 559
                  |||...|                    .|:.|
Mouse   619 PTKEKKRKLTPEEPGSLPAPNLEMKRQRQSFLPCLRRGSLPKAQPCSEPRTPKRERASSPSPSSR 683

  Fly   560 --------SRVILGKNHVFRFTNPEQARELRDKIETENEAENEVEKTDTQQ-VDWNFAQCEL 612
                    |||.||.:.:...:.| .|...||...|.|.:|....|...|: |||.....||
Mouse   684 VCPATVIKSRVPLGPSALQNCSTP-LALPTRDLNTTFNVSEESPSKPSFQEFVDWEKVSPEL 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	145/375 (39%)
		Kinesin_assoc	355..498	CDD:465047	32/205 (16%)
		FHA_KIF1	474..574	CDD:438757	28/181 (15%)
		YhaN	<575..>666	CDD:443752	14/39 (36%)
		KIF1B	878..924	CDD:463574
		DUF3694	1199..1347	CDD:463599
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
Kif18b	NP_932063.2	KISc_KIP3_like	18..353	CDD:276821	136/355 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..508		17/116 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	602..642		5/39 (13%)
		Nuclear localization signal. /evidence=ECO:0000250	619..627		1/7 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	655..686		1/30 (3%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	800..834