DRSC/TRiP Functional Genomics Resources

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Protein Alignment unc-104 and KIF13A

DIOPT Version :9

Sequence 1:NP_611155.3 Gene:unc-104 / 36876 FlyBaseID:FBgn0267002 Length:1739 Species:Drosophila melanogaster
Sequence 2:NP_071396.4 Gene:KIF13A / 63971 HGNCID:14566 Length:1805 Species:Homo sapiens


Alignment Length:2025 Identity:578/2025 - (28%)
Similarity:874/2025 - (43%) Gaps:614/2025 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKR----FNFDYSYWSHDH 62
            :.|||||||||.|.||:...:||::||.|..|.:..|  |.||....::    |.|||.:||.|.
Human     4 TKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPP--PSNTKQGERKPPKVFAFDYCFWSMDE 66

  Fly    63 -HDADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDL 126
             :...::.|.:|:|.:||.:|:.:|.|||.|||||||||:|||::|||..|  |.|:||.:|..|
Human    67 SNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAE--QLGLIPRLCCAL 129

  Fly   127 FTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPK-NKGNLRVREHPLLGPYVEDLSKLAVTDYQ 190
            |.||...:.:...:.|||||||||.|:|||||:|| ::.:|:||||.:|||||:.||:||||.::
Human   130 FKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGLSQLAVTSFE 194

  Fly   191 DIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERA 255
            ||..|:.||||:||||||||||.||||||||.|..||..:||.:..:.|||||:||||||||||.
Human   195 DIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERV 259

  Fly   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGNS 320
            ..|||.|.|||||:||||||||||.|||:||:.|:.|..:|   |:|||||.|||||::||||||
Human   260 SKTGAAGERLKEGSNINKSLTTLGLVISSLADQAAGKGKSK---FVPYRDSVLTWLLKDNLGGNS 321

  Fly   321 KTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGI 385
            :|:|||.||||..||:|||||||||||||:||..||||||.|||:||||:||::|||        
Human   322 QTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAKVIRELREEVEKLR-------- 378

  Fly   386 EVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQREA 450
                 ::|:::..:|:|...            ::|:.|||||.||..||||||::||||..:|:.
Human   379 -----EQLSQAEAMKAPELK------------EKLEESEKLIKELTVTWEEKLRKTEEIAQERQR 426

  Fly   451 VFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLS 515
            ....||::::..||.||    ....:|||||.||.|:|.|:||:|:. ||:|   |:..|||||.
Human   427 QLESMGISLEMSGIKVG----DDKCYLVNLNADPALNELLVYYLKDH-TRVG---ADTSQDIQLF 483

  Fly   516 GSHILKEHCTFE-NKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQAR 579
            |..|..:||..: ..:..|||.|.::|...|||..:.....|..|.|::.|.||.||...|::.|
Human   484 GIGIQPQHCEIDIASDGDVTLTPKENARSCVNGTLVCSTTQLWHGDRILWGNNHFFRINLPKRKR 548

  Fly   580 E--LRD-KIET---ENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEMKKRLDNLEEQYKRE 638
            .  |:| :.||   |::.:...|.:.....::.|||.|::.|. ::....::..:..||:||..|
Human   549 RDWLKDFEKETGPPEHDLDAASEASSEPDYNYEFAQMEVIMKT-LNSNDPVQNVVQVLEKQYLEE 612

  Fly   639 KLQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNPMYESCWTAREA 703
            |..|   .||||..||..::.|::|:             ||:  .|.:....:.:..|..||::.
Human   613 KRSA---LEEQRLMYERELEQLRQQL-------------SPD--RQPQSSGPDRLAYSSQTAQQK 659

  Fly   704 GLAAWA------FRKWRYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQFQFTLLTDTLYSPLP 762
             :..||      ||:    ....||:.|......::|||.::.|:.|...:|.||       .:|
Human   660 -VTQWAEERDELFRQ----SLAKLREQLVKANTLVREANFLAEEMSKLTDYQVTL-------QIP 712

  Fly   763 PELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNGATHHWSLEKLRYRLELMRQIYNVESPPSS 827
               |:.::...:.....:.|      |::|. .|..:|..|::|||..:|..||.:|        
Human   713 ---AANLSANRKRGAIVSEP------AIQVR-RKGKSTQVWTIEKLENKLIDMRDLY-------- 759

  Fly   828 MLFDTSGMEALSGWISPPSQHPGQQAQLLPLEPPVESERGRLTLANLIPSRQRLELMREMYHNEA 892
                       ..|                      .|:        :|..:||...|       
Human   760 -----------QEW----------------------KEK--------VPEAKRLYGKR------- 776

  Fly   893 EMSPTSPDYNVESLTGGDPFYDRFPWFRMVGRSFIYLSNLLYPVPLVHKVAIVNERGDVRGYLRI 957
                            |||||:......::|.:.::|..|...|.|.:.|.|::::|:|.|.|.:
Human   777 ----------------GDPFYEAQENHNLIGVANVFLECLFCDVKLQYAVPIISQQGEVAGRLHV 825

  Fly   958 AVQPVLDEESIDFNNGVKQSARLVFNEDDAKPKYRALNEKDDVQRYIDNGGLDSKLEELEDVDSG 1022
            .|..|        ...|.:  |:|  |||:...                   .|:...||.|||.
Human   826 EVMRV--------TGAVPE--RVV--EDDSSEN-------------------SSESGSLEVVDSS 859

  Fly  1023 RGIDSNSASECHENSEEPGEHLQVGKEFTFRVTVLQATGIGAEYAD-IFCQFNFLHRHEEAFSTE 1086
                              ||.:...|:.|.||.:.:|||:....:: :|||:.|..:.|...:. 
Human   860 ------------------GEIIHRVKKLTCRVKIKEATGLPLNLSNFVFCQYTFWDQCESTVAA- 905

  Fly  1087 PVKNSASGAP--------LGFYHVQNITVPVTKSFIEYLKTQPIMFKIFGH---------YQTHP 1134
            ||.:....:|        :.|.|.::..|.||:.|:|::....:..:::||         ::...
Human   906 PVVDPEVPSPQSKDAQYTVTFSHCKDYVVNVTEEFLEFISDGALAIEVWGHRCAGNGSSIWEVDS 970

  Fly  1135 LHKDAKQDFVSRPPPRRMLPPSIPISQPVRSPKFGPLPCAPTSTVLAKHD--------VLVWFEI 1191
            ||                                     |.|.|:   ||        :.:|..|
Human   971 LH-------------------------------------AKTRTL---HDRWNEVTRRIEMWISI 995

  Fly  1192 CELAPNGEYVPSVVEHSDDLPCRGLFLLHQGIQRRIRIT---IVHEPTTEV-------------- 1239
            .||...|||....:..:.|:...|:|.|.||..||:::|   :.|..|..:              
Human   996 LELNELGEYAAVELHQAKDVNTGGIFQLRQGHSRRVQVTVKPVQHSGTLPLMVEAILSVSIGCVT 1060

  Fly  1240 ------------------------------------KWKD--------INELVVGRIRNTPESSD 1260
                                                :|.|        ::|.:......|.::.|
Human  1061 ARSTKLQRGLDSYQRDDEDGDDMDSYQEEDLNCVRERWSDALIKRREYLDEQIKKVSNKTEKTED 1125

  Fly  1261 EQDEDACVLS--LGLF-------------------------PGEALEVP-------GDDRS---- 1287
            :.:.:|.::.  :||.                         ||....:|       .||.|    
Human  1126 DVEREAQLVEQWVGLTEERNAVLVPAPGSGIPGAPADWIPPPGMETHIPVLFLDLNADDLSANEQ 1190

  Fly  1288 ---------------------FY-----------RFEAAWDSSLHNSALLNRVSQGGETIYITLS 1320
                                 ||           ...|:||||:|:|..||||:...|.||:.:.
Human  1191 LVGPHASGVNSILPKEHGSQFFYLPIIKHSDDEVSATASWDSSVHDSVHLNRVTPQNERIYLIVK 1255

  Fly  1321 AYLELEN-CARPAIITKDLSMVIYGRDARTGPR----SLKHLFSGQYRNPEANRLTGV-YELA-- 1377
            ..::|.: .|...::.|.::..||.:.:.|...    |||::|..          .|| ||:.  
Human  1256 TTVQLSHPAAMELVLRKRIAANIYNKQSFTQSLKRRISLKNIFYS----------CGVTYEIVSN 1310

  Fly  1378 LRRASEAGSPGVQRRQRRVLDTSSTYVRGEENLHGWRPRGDSLIFDHQWELEKLTR-------LE 1435
            :.:|:|.    ::.|     :|.:......||      .|.|   |.:..:||.||       :.
Human  1311 IPKATEE----IEDR-----ETLALLAARSEN------EGTS---DGETYIEKYTRGVLQVENIL 1357

  Fly  1436 EVGRMRHLLLLRERLGMDTNPNPTTKTEKDVCNLAARAATSPVHMVIPQSPQTPVKD------PQ 1494
            .:.|:|..:.::|.|        :||..    ::....:|..||.|....|.....|      |:
Human  1358 SLERLRQAVTVKEAL--------STKAR----HIRRSLSTPNVHNVSSSRPDLSGFDEDDKGWPE 1410

  Fly  1495 QIIPEREYNQREQDLMLKCLKLVQGRYTKSEANDTQTQSDVSPSDEGCADMTVSCISSNSMENNK 1559
            ..:...:|:...||  :.|.             .|..:.....:.|||...|...::        
Human  1411 NQLDMSDYSSSYQD--VACY-------------GTLPRDSPRRNKEGCTSETPHALT-------- 1452

  Fly  1560 FVIRRRLCSPDRADAPNGWEAPAPATQPALPLRLYVPELEEIRVSPVVARK-------------- 1610
                   .||.:|.:|.    |....:|.:|::....:...:...|:::::              
Human  1453 -------VSPFKAFSPQ----PPKFFKPLMPVKEEHKKRIALEARPLLSQESMPPPQAHNPGCIV 1506

  Fly  1611 -----GLLNVLEHGGSGWKK--------------RWVIVRRPYVFIYRSEKDPVERAVLNLATAH 1656
                 |....:||.....||              |.:|..:|||        |||.|..::..|.
Human  1507 PSGSNGSSMPVEHNSKREKKIDSEEEENELEAINRKLISSQPYV--------PVEFADFSVYNAS 1563

  Fly  1657 VECSEDQAAMVKIPN------------TFSVVTKHRGYLLQ-----TLGD--------------- 1689
            :|..|..::.|.:.|            |.|.:|.  ||...     ||.|               
Human  1564 LENREWFSSKVDLSNSRVLEKEVSRSPTTSSITS--GYFSHSASNATLSDMVVPSSDSSDQLAIQ 1626

  Fly  1690 -KE-----------VHDWLYAINPLLA----GQIKSRLARRTLE---------PASQTASQIQAT 1729
             |:           |||:..:.|..|.    |.:|.::....|:         |:||:..:..:.
Human  1627 TKDADSTEHSTPSLVHDFRPSSNKELTEVEKGLVKDKIIVVPLKENSALAKGSPSSQSIPEKNSK 1691

  Fly  1730 NAANANSASK 1739
            :.....|.|:
Human  1692 SLCRTGSCSE 1701

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-104NP_611155.3 KISc_KIF1A_KIF1B 2..358 CDD:276816 213/361 (59%)
KISc 3..358 CDD:214526 213/360 (59%)
Kinesin_assoc 355..498 CDD:292801 59/142 (42%)
FHA 475..574 CDD:238017 42/99 (42%)
KIF1B 878..923 CDD:289208 8/44 (18%)
DUF3694 1246..1347 CDD:289256 33/171 (19%)
PH_KIFIA_KIFIB 1602..1704 CDD:269939 33/178 (19%)
PH 1607..1700 CDD:278594 31/169 (18%)
KIF13ANP_071396.4 KISc_KIF1A_KIF1B 5..359 CDD:276816 213/360 (59%)
Kinesin_assoc 356..468 CDD:318424 58/140 (41%)
FHA 446..543 CDD:238017 42/100 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 556..575 4/18 (22%)
SMC_N <606..771 CDD:330553 53/253 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 633..656 5/37 (14%)
KIF1B 748..792 CDD:315155 16/115 (14%)
DUF3694 <1215..1279 CDD:315198 17/63 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1385..1404 6/18 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1507..1531 5/23 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1612..1645 4/32 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1749..1779
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D76316at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100247
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2883
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.850

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