DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-104 and kif1c

DIOPT Version :9

Sequence 1:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster
Sequence 2:	XP_009300278.1	Gene:	kif1c / 570771	ZFINID:	ZDB-GENE-090312-119	Length:	1185	Species:	Danio rerio

Alignment Length:	683	Identity:	433/683 - (63%)
Similarity:	519/683 - (75%)	Gaps:	49/683 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSH-DHHDA 65
            ||||||||||||||||..|.:||:|:|...:|.|||||.|   .:|.|.|.|||||||| ...|.
Zfish     4 SSVKVAVRVRPFNSRETNRGAKCVIQMQDKSTCITNPKQP---KESPKNFTFDYSYWSHSSEEDP 65

  Fly    66 DFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLFTRI 130
            .|::|..||:|||||||.|:|:||||||||||||||||||||||:|:..|:||||.:|:|||.:.
Zfish    66 SFASQRKVYQDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQDPGQQGIIPQMCEDLFRQT 130

  Fly   131 QDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIHDL 195
            .:....||.:|||||||||||||||||||||:||.|||||||::|||||||||:|||:|.||.||
Zfish   131 AENTDPDLSFSVEVSYMEIYCERVRDLLNPKSKGALRVREHPIMGPYVEDLSKMAVTNYSDIADL 195

  Fly   196 IDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERADSTGA 260
            :|.|||||||||||||||||||||||||.|||.|||.||:|.||||||||||||||||||||:||
Zfish   196 MDTGNKARTVAATNMNETSSRSHAVFTILFTQHRHDHMTSLDTEKVSKISLVDLAGSERADSSGA 260

  Fly   261 KGTRLKEGANINKSLTTLGKVISALAEVASKKKN---TKKADFIPYRDSALTWLLRENLGGNSKT 322
            ||.|||||||||||||||||||||||::.|..::   .:::||||||||.|||||||||||||:|
Zfish   261 KGMRLKEGANINKSLTTLGKVISALADMVSPPQHGSKKRRSDFIPYRDSVLTWLLRENLGGNSRT 325

  Fly   323 AMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGI-- 385
            |||||:|||||||:|||||||||||||||.|.||:|||.||:|:||||||:.:|::||.::|:
Zfish   326 AMIAALSPADINYEETLSTLRYADRAKQIKCNAVINEDPNARLVRELKEEVNRLKELLLSQGLSN 390

  Fly   386 ----EVQEEDELTKSTVIKSP----------TKSRNRNGSTT---------EMAVDQLQASEKLI 427
                ...|......:.|:..|          |......|.||         |.|.::|:.:||:|
Zfish   391 LITASGSETGHPALAGVLGEPHQPSLPYVQSTSDAPMEGVTTTSPSEPISKEEAAERLKETEKII 455

  Fly   428 AELNETWEEKLKRTEEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLY 492
            |||||||||||::|||||..||::.|||||:|||||.||||||||||||||||||||.:||||:|
Zfish   456 AELNETWEEKLRKTEEIRQDRESLLAEMGVSVKEDGGTVGVFSPKKTPHLVNLNEDPLMSECLIY 520

  Fly   493 YIKEGLTRLGTHEANVPQDIQLSGSHILKEHCTF-----ENKNSTVTLLPHKDAIIYVNGRKLVE 552
            |||:|:||:|..:.    ||:|||..|.:.||.|     ||....|||.|...|..||||:::.|
Zfish   521 YIKDGVTRVGQEDV----DIRLSGQFIKELHCVFCSEINENNEVVVTLEPLVGAETYVNGKQVTE 581

  Fly   553 PEVLKTGSRVILGKNHVFRFTNPEQARELRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQG 617
            ..|||.|:|:::||||||||.:|||||     :|.|..|..|.:   .:.|||::||.|||||||
Zfish   582 GVVLKQGNRIVMGKNHVFRFNHPEQAR-----LERERSATQEQQ---GEPVDWSYAQKELLEKQG 638

  Fly   618 IDLKAEMKKRLDNLEEQYKREKLQADQQFEEQR 650
            ||:|.||:|||.:||.||::||.:|||..|:||
Zfish   639 IDIKQEMEKRLQDLENQYRKEKEEADQILEQQR 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	269/359 (75%)
		KISc	3..358	CDD:214526	268/358 (75%)
		Kinesin_assoc	355..498	CDD:292801	87/167 (52%)
		FHA	475..574	CDD:238017	56/103 (54%)
		KIF1B	878..923	CDD:289208
		DUF3694	1246..1347	CDD:289256
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
		PH	1607..1700	CDD:278594
kif1c	XP_009300278.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	269/359 (75%)
		KISc	5..361	CDD:214526	268/358 (75%)
		Kinesin_assoc	358..526	CDD:292801	87/167 (52%)
		FHA	503..603	CDD:238017	56/103 (54%)
		FHA	<513..601	CDD:224630	44/91 (48%)
		MPLKIP	967..>1099	CDD:292140
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131864at33208
OrthoFinder	1	1.000	-	-		FOG0001470
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100247
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920