Protein Alignment unc-104 and kif1ca

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: XP_068077671.2
• Gene: kif1ca / 570771
• ZFINID: ZDB-GENE-200303-1
• Length: 1185
• Species: Danio rerio
• Alignment Length: 1233
• Identity: 525/1233 - (42%)
• Similarity: 668/1233 - (54%)
• Gaps: 312/1233 - (25%)

  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSH-DHHDA 65
            ||||||||||||||||..|.:||:|:|...:|.|||||.|   .:|.|.|.|||||||| ...|.
Zfish     4 SSVKVAVRVRPFNSRETNRGAKCVIQMQDKSTCITNPKQP---KESPKNFTFDYSYWSHSSEEDP 65

  Fly    66 DFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLFTRI 130
            .|::|..||:|||||||.|:|:||||||||||||||||||||||:|:..|:||||.:|:|||.:.
Zfish    66 SFASQRKVYQDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQDPGQQGIIPQMCEDLFRQT 130

  Fly   131 QDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIHDL 195
            .:....||.:|||||||||||||||||||||:||.|||||||::|||||||||:|||:|.||.||
Zfish   131 AENTDPDLSFSVEVSYMEIYCERVRDLLNPKSKGALRVREHPIMGPYVEDLSKMAVTNYSDIADL 195

  Fly   196 IDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERADSTGA 260
            :|.|||||||||||||||||||||||||.|||.|||.||:|.||||||||||||||||||||:||
Zfish   196 MDTGNKARTVAATNMNETSSRSHAVFTILFTQHRHDHMTSLDTEKVSKISLVDLAGSERADSSGA 260

  Fly   261 KGTRLKEGANINKSLTTLGKVISALAEVASKKKN---TKKADFIPYRDSALTWLLRENLGGNSKT 322
            ||.|||||||||||||||||||||||::.|..::   .:::||||||||.|||||||||||||:|
Zfish   261 KGMRLKEGANINKSLTTLGKVISALADMVSPPQHGSKKRRSDFIPYRDSVLTWLLRENLGGNSRT 325

  Fly   323 AMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGIE- 386
            |||||:|||||||:|||||||||||||||.|.||:|||.||:|:||||||:.:|::||.::|:.
Zfish   326 AMIAALSPADINYEETLSTLRYADRAKQIKCNAVINEDPNARLVRELKEEVNRLKELLLSQGLSN 390

  Fly   387 ----------------VQEEDELTKSTVIKSPTKSRNRNGST---------TEMAVDQLQASEKL 426
                            |..|......:.::| |......|.|         .|.|.::|:.:||:
Zfish   391 LITASGSETGHPALAGVLGEPHQPSLSYVQS-TSDAPMEGVTPTSPSEPISKEEAAERLKETEKI 454

  Fly   427 IAELNETWEEKLKRTEEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLL 491
            ||||||||||||::|||||..||::.|||||:|||||.||||||||||||||||||||.:||||:
Zfish   455 IAELNETWEEKLRKTEEIRQDRESLLAEMGVSVKEDGGTVGVFSPKKTPHLVNLNEDPLMSECLI 519

  Fly   492 YYIKEGLTRLGTHEANVPQDIQLSGSHILKEHCTF-----ENKNSTVTLLPHKDAIIYVNGRKLV 551
            ||||:|:||:|..:.    ||:|||..|.:.||.|     ||....|||.|...|..||||:::.
Zfish   520 YYIKDGVTRVGQEDV----DIRLSGQFIKELHCVFCSEINENNEVVVTLEPLVGAETYVNGKQVT 580

  Fly   552 EPEVLKTGSRVILGKNHVFRFTNPEQARELRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQ 616
            |..|||.|:|:::||||||||.:|||||     :|.|..|..|.:   .:.|||::||.||||||
Zfish   581 EGVVLKQGNRIVMGKNHVFRFNHPEQAR-----LERERSATQEQQ---GEPVDWSYAQKELLEKQ 637

  Fly   617 GIDLKAEMKKRLDNLEEQYKREKLQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPED 681
            |||:|.||:|||.:||.||::||.:|||..|:||                         .|:..|
Zfish   638 GIDIKQEMEKRLQDLENQYRKEKEEADQILEQQR-------------------------LYADSD 677

  Fly   682 FHQEEDVYTNPMYESCWTAREAGLAAWAFRKWRYHQFTSLRDDLWGNAI--FLKEANAISVELKK 744
            ...:.|      ..||            ...||.  .:|||:.|..|.:  .:|:....|...::
Zfish   678 SGDDSD------KRSC------------EESWRL--ISSLREKLPANKMQSIVKKCGLPSSGKRR 722

  Fly   745 KVQFQFTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNGATHHWSLEKLR 809
            :              ||      .|..:.|.....|...||               |..|:|:|
Zfish   723 E--------------PL------RVYQIPQRRRIPATQESK---------------HRLSVEEL- 751

  Fly   810 YRLELMRQI-YNVESPPSSMLFDTSGMEALSGWISPPSQHPGQQAQLLPLEPPVESERGRLTLAN 873
             |.:.:::| |.|               ||..:     :|..|:.:.|
Zfish   752 -RTQAVKEICYEV---------------ALGDF-----KHTRQEIEAL----------------- 778

  Fly   874 LIPSRQRLELMREMYHNEAEMSPTSPDYNVESLTGGDPFYDRFPWFRMVGRSFIYLSNLLYPVPL 938
                  .:..|:|:.....:..|                .:|..| :.|.:.            :
Zfish   779 ------AIVRMKELCRTYCQKDP----------------QERETW-KSVAKD------------V 808

  Fly   939 VHKVAIVNERGDVRGYLRIAVQPVLD------------EESIDFNNGVKQSARLVFNEDDAKPKY 991
            ...|.|..|.||...  |||....:.            :..||....:.|..:|..|..|  .:.
Zfish   809 CETVGIGEEEGDRED--RIAAAAAVGGSEGGKTDMGDLKAHIDKLTDILQEVKLQNNMKD--EEI 869

  Fly   992 RALNEKDDVQRYIDNGGLDSKLEEL---------EDVDSGRGIDSNSASECHENSEEPGEHLQVG 1047
            |:|.:     |.:       |:|::         |||:.|........::.:..:|:.|  .:.|
Zfish   870 RSLRD-----RMV-------KMEKIFPVDVKGDDEDVEFGGARVEEPTAQVNRRNEDSG--YRRG 920

  Fly  1048 KEFTFRVTVLQATGIGAEYADIFCQFNFLHR--HEEAFSTEPVKNSASGAPLGFYHVQNITVPVT 1110
            :                            ||  :.|.:.....:..|:..|      .|.
Zfish   921 R----------------------------HRWQYPEKYHDPKRRKGANNQP------NNA----- 946

  Fly  1111 KSFIEYLKTQPIMFKIFGHYQTHPLHKDAKQDFVSRPPPRRMLPPSIPISQPVRSPKFGP-LP 1172
                  |.|.|.     ||.|.:|.:..:     |||.     .||.. |||.|:|. || ||
Zfish   947 ------LYTPPT-----GHSQNNPFNTAS-----SRPS-----NPSFN-SQPSRNPN-GPFLP 986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	269/359 (75%)
		Kinesin_assoc	355..498	CDD:465047	86/168 (51%)
		FHA_KIF1	474..574	CDD:438757	57/104 (55%)
		YhaN	<575..>666	CDD:443752	41/90 (46%)
		KIF1B	878..924	CDD:463574	6/45 (13%)
		DUF3694	1199..1347	CDD:463599
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
kif1ca	XP_068077671.2	None