Protein Alignment unc-104 and kif21b

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: XP_073772347.1
• Gene: kif21b / 570502
• ZFINID: ZDB-GENE-130530-537
• Length: 1669
• Species: Danio rerio
• Alignment Length: 1443
• Identity: 331/1443 - (22%)
• Similarity: 561/1443 - (38%)
• Gaps: 382/1443 - (26%)

  Fly     3 SVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSHDHHDADF 67
            ||||::|:||    ::|:|.   ||.....|::| |..|.......|.|.:|:.:      |.|
Zfish     8 SVKVSLRIRP----QMAKEK---IEGCHICTSVT-PGEPQVLLGKDKAFTYDFVF------DLD- 57

  Fly    68 STQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTM-MG---RQEEQQEGIIPMICKDLFT 128
            :.|..:|.....::::..|:|||..:|||||||:||:||| .|   ...|.::||||.....||.
Zfish    58 AHQQQIYSACVHKLIEGCFEGYNATVFAYGQTGSGKTYTMGTGFDVSVSEDEQGIIPRAVHQLFQ 122

  Fly   129 RIQ----DTETDDL---KYSVEVSYMEIYCERVRDLL----NPKNKG---NLRVREHPLLGPYVE 179
            .||    :.::.|:   .:.|...::|:|.|.:.||.    :|:.:|   |:::.|....|.|..
Zfish   123 GIQKRRLEAQSADIPPPDFKVSAQFLELYNEEILDLFDSTRDPEARGRKSNIKIHEDGSGGIYTT 187

  Fly   180 DLSKLAVTDYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRR--------------- 229
            .::...|:...::...:..|..:||.|:|.||..||||||:|||...|.|
Zfish   188 GVTSRLVSSEDELLQCLKLGALSRTTASTQMNAQSSRSHAIFTIHLCQMRVCPQPQLVNGELNGV 252

  Fly   230 -HDLMTNLTTEKVS-KISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKK 292
             ...|:....|.:| |...||||||||...|||.|.|.:||.:||..|..||.|||||.:
Zfish   253 SDGSMSQSEYETLSAKFHFVDLAGSERLKRTGATGERAREGISINCGLLALGNVISALGD----- 312

  Fly   293 KNTKKADFIPYRDSALTWLLRENLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVV 357
             .:|:|..:|||||.||.||:::|||||:|.|||.:||:|.::.|||:||:||:||:.|..|.:|
Zfish   313 -QSKRAGHVPYRDSKLTRLLQDSLGGNSRTVMIACVSPSDRDFMETLNTLKYANRARNIKNKVIV 376

  Fly   358 NEDANAKLIRELKEEIQKLR----------------------DLLKAEGIEVQEEDEL------- 393
            |:|..::.|..|:.||.:|:                      ||.:...:..:|.|.|
Zfish   377 NQDKTSQQISALRAEIARLQMEIMEYKAGKRVACDEGSEGFSDLFQENSMLQRENDTLRMRVKAM 441

  Fly   394 --------TKSTVIKSP------TKSRNRNGSTTEMAVDQLQASEKLIAEL--NETWEEKLKRTE 442
                    |:.|.:.:.      ||:...|.....:..:.::..|:|.::|  :|...|.|:|:.
Zfish   442 QETIDHLNTRVTQLLTNGVNLLLTKTGETNEEIGNLIQNYIREIEELRSKLLESEAMNESLRRSL 506

  Fly   443 EIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEAN 507
            . |:...:|:                  |...|...::...|::|             :.....:
Zfish   507 S-RLSSRSVY------------------PSSHPSAPSIGSSPSVS-------------MEAEMTD 539

  Fly   508 VPQDIQLSGSHILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRF 572
            |.:..:|....:.|:......|.      |.|:.  .:..|..:.||  ::|.:...|.|..
Zfish   540 VIRQAKLDVERLKKKERNQRRKR------PEKEK--GLKKRAKLHPE--ESGEKSENGLNRA--- 591

  Fly   573 TNPEQARELRDKIETENEAENEVEKT---DTQQVDWNFAQCELLEKQGIDLKAEM-----KKRLD 629
              .|:.||..|     .:::||.|:.   ..|:.|...:.|:..|::..:.:.|.     :..:|
Zfish   592 --NEERRENGD-----GDSDNEPEEDGMYPLQEDDHGESGCDEEEEEEEETREEEEFDSDESLVD 649

  Fly   630 NLEEQYKREKLQAD-----------QQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFH 683
            :..:..::..||||           |:..::.:..:.|:..|:.|.||:.:.:    .....|..
Zfish   650 SDSDTDEKVNLQADLADLTCEIEIKQRLIDELENSQRRLLTLKSQYEEKLILL----QNKIRDTQ 710

  Fly   684 QEED-VYTNPMYESCWTAREAGLAAWAFRKWRYHQFTSLRDDLW-------GNAIFLKEANAISV 740
            .|.| |..|.|....:|..:|......:.|    :...:..||.       .:|..||.......
Zfish   711 LERDRVLHNLMSMENYTEEKASKVKSEYEK----RLKEMNRDLLKLQAAQKEHARLLKNQGRYER 771

  Fly   741 ELKKKVQFQFTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKTLVAV-----------EVTD 794
            ||||                    |.|.||           .:.|..||:           .:.|
Zfish   772 ELKK--------------------LQSEVA-----------EMKKAKVALMKQMKEEQQRRRMID 805

  Fly   795 TKNGATHHWSLEKLRYRLELMRQIYNVESPPSS-------MLFDTSGMEALSGWISPPSQHPGQQ 852
            .|.      :.|..:.:.|..||.|.:.:..|.       :...|..:.||.....|.|:....:
Zfish   806 AKR------NREIAQLKKEQRRQEYQIRALESQKRQQELVLRRKTQEVTALRRLAKPLSERAAGR 864

  Fly   853 A--QLLPLEPPVESERGRLTLANLIP--SRQRLELMREM------YHNE-------AEMSPTSPD 900
            .  :|..::...|......|..:..|  ||....::|..      |..|       |.|:.:...
Zfish   865 VSRRLTSVDSGAELSTSTTTTTSSEPESSRSVSSIIRHWNTKLNGYLGETDSHAPAANMASSRKK 929

  Fly   901 YNVESLTGGDPFYDRFPWFRMVGRSFIYLSNLLYPVPLVHKVAIVNERGDVRGYLRIAVQPVLDE 965
            :..:..:.|.....|..|..:..|    :.::     ::.::.|.|...|:...::...:..:.:
Zfish   930 FQRKGPSSGFSKTARQKWQSLERR----IMDI-----VMQRMTITNVEADMDRLIKKREELSVQQ 985

  Fly   966 ESIDFNNGVKQSARLV---FNEDDAKPKYRALNEKDDVQR----YIDNG---------GLDSKLE 1014
            |::     :::..:|:   |.|:|.:...:.:||:.:|..    ||.:.         .::...:
Zfish   986 EAL-----LRKREKLLSESFREEDEERLLQEMNEEIEVLNANIDYISDSLSDCQATIVQIEETKD 1045

  Fly  1015 ELEDVDSGRGIDSNSASECH-------ENSEEPGEHLQVG-KEFTFRV---TVLQATGIGA---- 1064
            ||:.||:...|.|.|.:|..       :.|.:.|  |||. ||...|:   .:.|...||:
Zfish  1046 ELDSVDTSVVISSCSLAEARSLLDYFLKASIDKG--LQVAQKEAQIRLLEGQLRQTDVIGSSHNH 1108

  Fly  1065 -------EYADIFCQFN-FLHRHEE----AFSTEPVKNSASGAPLGFYHV--------------- 1102
                   |.|:...:.. .:|..::    |.:.|.|...:..:..||..:
Zfish  1109 MILDALREKAECIPELQALIHNVQQENGYASTDEEVSEFSQASESGFSQMKLSASQDDFKMKVEP 1173

  Fly  1103 ----------------------QNITVPVTK-------------SFIEYLKTQPIMFKIFGHYQT 1132
                                  :|||..:..             ::...|.::.|...|.||  |
Zfish  1174 RLSAQMKAVSAEYLGPILDLNSKNITKSLASLSEIQENGLLLKDTYCRELVSRTISLPIRGH--T 1236

  Fly  1133 HPLHKDAKQDFVSRPPPRRMLPPSIPISQPVRSPKFGPLPCAPTSTVLAKHDVLVWFEICELAPN 1197
            .|.......   :.|..||.   |....||.|||..|..| .|:..:..::|..|:..:......
Zfish  1237 FPRQSRGSD---ASPLTRRQ---SYDRGQPYRSPDVGYTP-PPSPPLRQRNDRNVFSRLTSNQSQ 1294

  Fly  1198 GEYVPSVVEHSDD 1210
            |    |.::.|||
Zfish  1295 G----SALDKSDD 1303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	143/389 (37%)
		Kinesin_assoc	355..498	CDD:465047	31/187 (17%)
		FHA_KIF1	474..574	CDD:438757	15/99 (15%)
		YhaN	<575..>666	CDD:443752	21/109 (19%)
		KIF1B	878..924	CDD:463574	9/58 (16%)
		DUF3694	1199..1347	CDD:463599	4/12 (33%)
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
kif21b	XP_073772347.1	None