Protein Alignment unc-104 and kif1ab

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: XP_009296795.1
• Gene: kif1ab / 566766
• ZFINID: ZDB-GENE-070912-480
• Length: 1799
• Species: Danio rerio
• Alignment Length: 1865
• Identity: 979/1865 - (52%)
• Similarity: 1254/1865 - (67%)
• Gaps: 228/1865 - (12%)

  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSH-DHHDA 65
            :||||||||||||||||.::|||||:|:|.||.|.|||.|...    |.|||||||||| ...|.
Zfish     4 ASVKVAVRVRPFNSREIGKDSKCIIQMSGNTTTILNPKQPKEN----KSFNFDYSYWSHTTPEDV 64

  Fly    66 DFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLFTRI 130
            :::.|..||:|||||||.|:|:||||||||||||||||||||||:||:.||||||::|:||||:|
Zfish    65 NYACQKQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQEGIIPLLCEDLFTKI 129

  Fly   131 QDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIHDL 195
            .|...:::.||||||||||||||||||||||||||||||||||:|||||||||||||.|.||.||
Zfish   130 NDNNDNNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLMGPYVEDLSKLAVTSYNDIQDL 194

  Fly   196 IDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERADSTGA 260
            :|.|||||||||||||||||||||||.|.|||::||..:..||||||||||||||||||||||||
Zfish   195 MDSGNKARTVAATNMNETSSRSHAVFNIIFTQKQHDNDSENTTEKVSKISLVDLAGSERADSTGA 259

  Fly   261 KGTRLKEGANINKSLTTLGKVISALAEVAS---KKKNTKKAD-FIPYRDSALTWLLRENLGGNSK 321
            |||||||||||||||||||||||||||:.|   |.|..||.: |||||||.|||||||||||||:
Zfish   260 KGTRLKEGANINKSLTTLGKVISALAEMDSAPNKNKKKKKVESFIPYRDSVLTWLLRENLGGNSR 324

  Fly   322 TAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGI- 385
            |||:||:|||||||||||||||||||||||.|.||:|||.|.:|:||||||:.:|:|||.|:|:
Zfish   325 TAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNRLVRELKEEVARLKDLLYAQGLG 389

  Fly   386 --------------EVQEEDE------LTKSTVIKSPTKS----RNRNGST------------TE 414
                          .:|..::      :|.:....||:.|    .:|.||.            :|
Zfish   390 DIIENLSNYKANISSIQAVNQRGDFSTVTNAMTGMSPSPSLSALTSRVGSISSLHDRIMFSPGSE 454

  Fly   415 MAVDQLQASEKLIAELNETWEEKLKRTEEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVN 479
            .|:::|:.:||:||||||||||||:|||.||::|||:.||||||::|||.|||||||||||||||
Zfish   455 EAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTVGVFSPKKTPHLVN 519

  Fly   480 LNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLSGSHILKEHCTFENKNS-----TVTLLPHK 539
            |||||.:|||||||||:|:|::|..:|:..|||.|||..|..|||.|.:..:     ||.|.|.:
Zfish   520 LNEDPLMSECLLYYIKDGITKVGREDASSRQDIVLSGHFIKDEHCIFTSTTNAIGEGTVVLEPCE 584

  Fly   540 DAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQARELRDKIETENEAENEVEKTDTQQVD 604
            .|..||||:::.||.|||:|:|:|:||:|||||.:|||||:.|::....:        |..:.||
Zfish   585 GAETYVNGKRVTEPTVLKSGNRIIMGKSHVFRFNDPEQARQDRERTPCAD--------TPVEPVD 641

  Fly   605 WNFAQCELLEKQGIDLKAEMKKRLDNLEEQYKREKLQADQQFEEQRKTYEARIDALQKQVEEQSM 669
            |.|||.|||||||||:|.||.:||..||:||::|:.:|....|:||..||::::||||||.
Zfish   642 WAFAQRELLEKQGIDMKQEMDQRLQELEDQYRKEREEASNLLEQQRLDYESKLEALQKQVN---- 702

  Fly   670 TMSMYSSYSPEDFHQEEDVYTNPMYESCWTAREAGLAAWAFRKWRYHQFTSLRDDLWGNAIFLKE 734
                 |.|.||...:||::..    |..||.||..||.|||||||::|||||||.||||||||||
Zfish   703 -----SRYYPETTEEEEELED----EVPWTKRETELALWAFRKWRFYQFTSLRDLLWGNAIFLKE 758

  Fly   735 ANAISVELKKKVQFQFTLLTDTLYSPLPPE-LASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNG 798
            ||||||||||||||||.||||||||||||: |..::|...::..|     .:|:|||||.|.|||
Zfish   759 ANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPSIAKDREKRLF-----PRTIVAVEVQDQKNG 818

  Fly   799 ATHHWSLEKLRYRLELMRQIYN--VESPPSSM---------------------------LFDTSG 834
            |||:|:|:|||.||:|||::|:  .|.|.:::                           :.:|..
Zfish   819 ATHYWTLDKLRQRLDLMREMYDRAAEVPSTAVEDCDHIMSGGDPFYDRFPWFRLVGRTPILNTCM 883

  Fly   835 MEALSG-WISPPSQHPGQQAQLLPLE---PPVESERGRLTLAN--LIPSRQRLELMREMYHNE-- 891
            .|.:|| .:||....|......|..|   ..||.|...|...:  :.......||.||...::
Zfish   884 SERMSGLTLSPTLSDPDSDITELADERHYGKVEVEEEELEDLDDEIFVEDNGSELGREEEEDDDD 948

  Fly   892 --AEMSPTSPDYNVESLTGGDPFYDRFPWFRMVGRSFIYLSNLLYPVPLVHKVAIVNERGDVRGY 954
              .|..|...|       |.||||||:|.|.:|||:|:|||||||||||||:||||:|:|:|:|:
Zfish   949 GVGERCPGVSD-------GQDPFYDRWPLFSLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGF 1006

  Fly   955 LRIAVQPV-LDEESIDFNNGVKQS--ARLVFNEDDAKPKYRA---------LNEKDDVQRYIDNG 1007
            ||:|||.: .|||:.|:.:||:||  |::.| ||.|..|::.         .:..::..|.::..
Zfish  1007 LRVAVQAISADEEAPDYGSGVRQSGTAKISF-EDQAFEKFQTEACTSGMSQTHTSEEELRIVEGE 1070

  Fly  1008 GLDSKLE-ELEDVDSGRGIDSNSAS--------EC--HENSEEPGEHLQVGKEFTFRVTVLQATG 1061
            |.:|:|. ..::|::...:.|...|        ||  ....::..:||::|..||||||||||:.
Zfish  1071 GQNSELGLSADEVNNNTCLVSPDISDSPLKGVLECPLDVTQDKSLQHLKIGSNFTFRVTVLQASS 1135

  Fly  1062 IGAEYADIFCQFNFLHRHEEAFSTEPVKNSASGAPLGFYHVQNITVPVTKSFIEYLKTQPIMFKI 1126
            |.||||||||||||:|||:|||||||:||:..|.||||||||||||.|||||:||:|:|||:|::
Zfish  1136 ISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNITVEVTKSFVEYIKSQPIVFEV 1200

  Fly  1127 FGHYQTHPLHKDAKQDFVSRPPPRRMLPPSIPISQPVRSPKFGPLPCAPTSTVLAKHDVLVWFEI 1191
            |||||..|.....|....|..|.||..|..:|:|:||.:.|...|..:.......|:|::.:|||
Zfish  1201 FGHYQKQPFPPLCKDLISSLRPMRRQFPRVMPLSKPVPATKLSTLARSTAGPCHCKYDLMAFFEI 1265

  Fly  1192 CELAPNGEYVPSVVEHSDDLPCRGLFLLHQGIQRRIRITIVHEPTTEVKWKDINELVVGRIRNTP 1256
            |||..||:|:|:||:|...:||.|.|||||||||||.:||.||...:::||::.|||:|||||||
Zfish  1266 CELEANGDYIPAVVDHRGGMPCHGTFLLHQGIQRRITVTIAHETGNDIEWKEVKELVIGRIRNTP 1330

  Fly  1257 ESSDEQDEDACVLSLGLFPG--------EALEVPGDDRSFYRFEAAWDSSLHNSALLNRVSQGGE 1313
            | :||...|..:|||.:...        :.:.:..|.|:|||||||||||:|||.|||||:..||
Zfish  1331 E-ADETIIDPNILSLNILSSNYIRPTYDDRVSLGSDHRTFYRFEAAWDSSMHNSLLLNRVTPYGE 1394

  Fly  1314 TIYITLSAYLELENCARPAIITKDLSMVIYGRDAR-TGPRSLKHLFS-GQYRNPEANRLTGVYEL 1376
            .||||||||||:|||.:|.::|||..||.|.|||: ...||:::||| |.:|..|:|.:||||||
Zfish  1395 KIYITLSAYLEMENCTQPTVVTKDFCMVFYSRDAKLPASRSIRNLFSTGAFRPLESNCVTGVYEL 1459

  Fly  1377 ALRRASEAGSPGVQRRQRRVLDTSSTYVRGEENLHGWRPRGDSLIFDHQWELEKLTRLEEVGRMR 1441
            :|...::.||||:|||:|||||||..||||||||.|||||.||||.|||||||||:.|:||.:.|
Zfish  1460 SLCHLADIGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELEKLSLLQEVEKTR 1524

  Fly  1442 HLLLLRERLGMDTNPNPTTKTEKDVCNLAARAATSPVHMVIP------QSPQTPVKDPQQIIPER 1500
            |.|||||:|.........:...||:  |.:..|.||  |:.|      .||
Zfish  1525 HYLLLREKLEASLLLGQDSFYGKDL--LDSPKANSP--MISPVMSLGLDSP-------------- 1571

  Fly  1501 EYNQREQDLMLKCLKLVQGRYTKSEANDTQTQSDVSPSDEGCADMTVSCISSNSMENNKFVIRRR 1565
              |:|:::|..||::|:...:.:..   :|..|.:|.|       .:|.||::       ::|..
Zfish  1572 --NERQRELAAKCVRLLMHTFNRQY---SQVSSSLSES-------KLSEISAS-------LLRDS 1617

  Fly  1566 LCSPDRADAPN----------------GWEAPAPATQPAL----PLR------LYVPELEEIRVS 1604
            :.||..:..|:                |.||.:.|:.|.|    |:.      .::|.::|||||
Zfish  1618 VTSPLSSLTPSSTCPSLLDGHYSTDLRGAEANSGASSPDLDPFSPIERKPRTCTFIPNIQEIRVS 1682

  Fly  1605 PVVARKGLLNVLEHGGSGWKKRWVIVRRPYVFIYRSEKDPVERAVLNLATAHVECSEDQAAMVKI 1669
            |:|::||.|:.||...|||.||:::||||||::||||:|.||||::||::|.||.|||...:::.
Zfish  1683 PIVSKKGYLHFLEPHTSGWVKRYIVVRRPYVYLYRSERDYVERAIINLSSAQVEYSEDHHTLMRA 1747

  Fly  1670 PNTFSVVTKHRGYLLQTLGDKEVHDWLYAINPLLAGQIKSRLARR 1714
            ||||:|.|:||..|||...|||:||||||.||||||.|:|:|:||
Zfish  1748 PNTFTVCTEHRNILLQATNDKEMHDWLYAFNPLLAGTIRSKLSRR 1792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	280/360 (78%)
		Kinesin_assoc	355..498	CDD:465047	90/179 (50%)
		FHA_KIF1	474..574	CDD:438757	59/104 (57%)
		YhaN	<575..>666	CDD:443752	44/90 (49%)
		KIF1B	878..924	CDD:463574	17/49 (35%)
		DUF3694	1199..1347	CDD:463599	86/155 (55%)
		PH_KIFIA_KIFIB	1602..1704	CDD:269939	61/101 (60%)
kif1ab	XP_009296795.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	280/360 (78%)
		Kinesin_assoc	358..538	CDD:465047	90/179 (50%)
		FHA	514..628	CDD:469597	64/113 (57%)
		ERM_helical	647..>702	CDD:466641	30/54 (56%)
		KIF1B	828..875	CDD:463574	10/46 (22%)
		DUF3694	1273..1428	CDD:463599	86/155 (55%)
		PH_KIFIA_KIFIB	1680..1782	CDD:269939	61/101 (60%)