Protein Alignment unc-104 and kif19

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: XP_005156460.1
• Gene: kif19 / 565913
• ZFINID: ZDB-GENE-080215-2
• Length: 1015
• Species: Danio rerio
• Alignment Length: 1030
• Identity: 261/1030 - (25%)
• Similarity: 427/1030 - (41%)
• Gaps: 294/1030 - (28%)

  Fly     6 VAVRVRPFNSREIARESKCII--EMAGATTAITNPKVPPNTSDSV--------KRFNFDYSYWSH 60
            ||:|:||.:..|: .|...||  ::......:.:|...|   |.:        |.:.||.::
Zfish    14 VALRIRPLSDAEL-EEGATIIAHKVDDQMVVLLDPMEDP---DDILRAHRSREKTYMFDVAF--- 71

  Fly    61 DHHDADFS-TQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICK 124
                 |:| ||..||:...:.:::....|||..:||||.||.||:|||:|  .:::.||......
Zfish    72 -----DYSATQDEVYRYTTKGLIEGLISGYNATVFAYGPTGCGKTYTMLG--TDREPGIYVRTLN 129

  Fly   125 DLFTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDY 189
            |||..|::| :||::|||.:||:|||.|.:|||||| :.|.|.:||.......|..:::::..:.
Zfish   130 DLFKAIEET-SDDMQYSVSMSYLEIYNEMIRDLLNP-SSGFLDLREDSKGEIQVAGITEVSTINA 192

  Fly   190 QDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQ--RRHDLMTNLTTEKVSKISLVDLAGS 252
            ::|.:|:.:|||.||...|..|:||||||||..:...|  |..|::..:   :.:::.::|||||
Zfish   193 REIMELLMKGNKQRTQEPTAANQTSSRSHAVLQVVVRQQSRCRDILQEV---RFARLFMIDLAGS 254

  Fly   253 ERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLG 317
            |||..|..:|.||||||:||:||..||..|:||:|     ||..|  ::.||||.||.||:::||
Zfish   255 ERASQTQNRGQRLKEGAHINRSLLALGNCINALSE-----KNGNK--YVNYRDSKLTRLLKDSLG 312

  Fly   318 GNSKTAMIAAISPADINYDETLSTLRYADRAKQI---VCKAVVNEDAN----AKLIRELKEEIQK 375
            |||:|.|||.||||.:.::::.:||.||||||.|   |.:.::|...:    ..:|.:|:.|||:
Zfish   313 GNSRTVMIAHISPASLAFEDSRNTLTYADRAKSIRTRVKRNLLNVSYHIAQYTSIISDLRSEIQR 377

  Fly   376 LRDLLKAEGIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKR 440
            |:..: |:....|...:.|....:::..::.:...|..||  |||:  |:||        :..::
Zfish   378 LKKKI-ADQASRQINPDRTDIRHVQAEVQAHSSQQSRAEM--DQLR--EQLI--------DAFRQ 429

  Fly   441 TEEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHE 505
            ..:||                          |:...|.|.|
Zfish   430 QMDIR--------------------------KRLMELDNSN------------------------ 444

  Fly   506 ANVPQDIQLSGSHILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVF 570
                .:||:..|..|.....:|.:
Zfish   445 ----MEIQIDTSKHLLTIADWEQE----------------------------------------- 464

  Fly   571 RFT-----NPEQARELRDKIETENEA---ENEVEKTDTQQVD-------WNFAQCELLEKQGIDL 620
            ||.     ..|:.:|..:|.|:|.::   |:..:.|:||:|.       ...|:.:.::||
Zfish   465 RFRRRKKWQGERRKESFNKDESEKDSDSPESLPDSTETQEVAIARENLVTLMAEQKKIQKQ---- 525

  Fly   621 KAEMKKRLDNLEEQYKR--EKLQADQQFEEQR-------KTYEARIDALQKQ------------- 663
            ||.:::||..|.|:.:|  |.|......||||       |.:|..|:..:.|
Zfish   526 KAGLEQRLAELREKARRLEELLPRRVSSEEQREVLCLLCKVHELEIENAEMQSSALLKDNVIRQK 590

  Fly   664 -----------------VEEQSMTMSMYSSYSPEDFHQEEDVYTNPMYESCWTAREAGLAAWAFR 711
                             :::|...:..:|...|....:..::|...|.|.. ..|...|..:..|
Zfish   591 NVVVQRFEQHRHLCHEIIQQQRQFIDDHSLLVPPHLQELYEMYMKEMDEKN-LDRVVALDKFTIR 654

  Fly   712 KWRYHQFTSL---------RDDLWGNAIFLKEANAISVELKKKVQFQFTLLTD-----------T 756
            ..:.|...||         ||.|              .||....:...||.:|           |
Zfish   655 TLKVHHEGSLPKITLPSRGRDPL--------------QELDSDQESVRTLASDNRQGRTKLRRHT 705

  Fly   757 LYSPLPPE-----------------LASTVAPVHQEDEFGAPPVSKTL-VAVEVTDTKNGATHHW 803
            | .|:.||                 :..|..|:|...:.....:...| .|:..:...:..:.|.
Zfish   706 L-PPILPEPDGERVFKSSHKQMKNTVVMTPPPIHINGQGNRELLPSVLDEALRCSHLSHSMSSHL 769

  Fly   804 -----SLEK-------LRYRLELMRQIYNVESPPSSMLFDTSGMEALSGWISPPSQHPGQQAQLL 856
                 |.|.       .:.|.:::|.:.|:....:........::||.  :.||..
Zfish   770 DSSPESSENGTDAPLTPKERQQILRGVQNIAVKAARRRSKVLEIDALR--LPPPPS--------- 823

  Fly   857 PLEPPVESERGRLTLANLIPSRQRLELMREMYHNEAEMSPTSPDYNVESLTGGDP 911
            ||:|  :..:..|:|:...|   :..::|.......|:...:.|.|:.|.||..|
Zfish   824 PLDP--KKHKSNLSLSEAPP---KGPVLRRGRQPSPELRHATSDDNLSSSTGDGP 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	145/367 (40%)
		Kinesin_assoc	355..498	CDD:465047	25/146 (17%)
		FHA_KIF1	474..574	CDD:438757	10/104 (10%)
		YhaN	<575..>666	CDD:443752	30/139 (22%)
		KIF1B	878..924	CDD:463574	8/34 (24%)
		DUF3694	1199..1347	CDD:463599
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
kif19	XP_005156460.1	KISc_KIP3_like	11..346	CDD:276821	143/357 (40%)
		EnvC	340..>558	CDD:443969	64/329 (19%)