DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-104 and kif14

DIOPT Version :9

Sequence 1:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster
Sequence 2:	XP_005170522.1	Gene:	kif14 / 562052	ZFINID:	ZDB-GENE-030131-5759	Length:	1506	Species:	Danio rerio

Alignment Length:	1205	Identity:	390/1205 - (32%)
Similarity:	568/1205 - (47%)	Gaps:	257/1205 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSHDHHDAD 66
            |:|.||||||||:|||...::..:|.|....|.:.:|     .:....:|.||:|:.|.:..||.
Zfish   234 SAVTVAVRVRPFSSREKIEKACQVIFMENQDTLVQHP-----DTKQTHKFTFDFSFCSINEADAS 293

  Fly    67 FSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLFTRIQ 131
            ||:|.::|:.:...:|:.:|:|:|.|:|||||||:||||||||..||  .|:||..|::||:|:.
Zfish   294 FSSQQLIYEKLARPLLERAFEGFNTCLFAYGQTGSGKSYTMMGFGEE--TGVIPRFCEELFSRLA 356

  Fly   132 DTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGN-----LRVREHPLLGPYVEDLSKLAVTDYQD 191
            .:||.::...:|:||.|:|.|::.|||..|::.|     |||||||:.||||.|||...|:.|.|
Zfish   357 RSETKEMSCHLEMSYFEVYNEKIHDLLVAKDEQNQKKMPLRVREHPVYGPYVADLSTNVVSSYSD 421

  Fly   192 IHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEK------VSKISLVDLA 250
            |...::.|||.|..|||.||:.|||||:|||:..||.:    |....|:      .|:|:|||||
Zfish   422 IKTWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTK----TEFVEEEEHDHCITSRINLVDLA 482

  Fly   251 GSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLREN 315
            ||||..|....|.||:|||:|||||.|||||||:|:|.:..:|..    |.|||:|.|||||:|:
Zfish   483 GSERCTSAQTSGDRLREGASINKSLLTLGKVISSLSEQSQSRKKV----FTPYRESVLTWLLKES 543

  Fly   316 LGGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDL- 379
            |||||||||||.:|||..|.:|:|||||||.:|:.|:..|.||||.||||||:||.|::|||..
Zfish   544 LGGNSKTAMIATLSPAASNMEESLSTLRYAQQARMIINIAKVNEDTNAKLIRDLKAEVEKLRAAQ 608

  Fly   380 LKAEGIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAV--DQLQASEKLIAELNETWEEKLKRTE 442
            :.::|:|               |.|.|.   ...|:|.  ::|...|..:||.:.||:|||:..|
Zfish   609 MSSQGVE---------------PEKMRL---FQQEIAALKNKLCQQEHEMAEAHRTWKEKLEEAE 655

  Fly   443 EIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEAN 507
            ..:.:........||..|.|         .:.|:||||||||.|||.|||.||||.|::|..::.
Zfish   656 RRKREEAKELQRAGVTFKVD---------NRLPNLVNLNEDPQLSEMLLYMIKEGQTKVGKLKSE 711

  Fly   508 VPQDIQLSGSHILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRF 572
            ...||||||:.|..:||...:...||::.|..:|..:|||..:.|..||..|.|||||.:|.|||
Zfish   712 SAHDIQLSGALIADQHCVISSVKGTVSIKPMPNAKTFVNGHLVSECTVLHHGDRVILGGDHYFRF 776

  Fly   573 TNPEQARELRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEMKK-RLDNLEEQYK 636
            .:|         .|.::........:.....|:.||:.|||..|...|:||::: ||...||..:
Zfish   777 NHP---------AEVQSGKRASCWSSGDGHKDFEFAKNELLSAQRAQLEAEIQEARLKAKEEMMQ 832

  Fly   637 R---EKLQADQQFEEQRKTYEARIDALQKQVEEQS---MTMSMYSSYSPEDFHQEEDVYTNPMYE 695
            .   .|..|.::..||:..||.:|.||:::::|:|   ....::...:.....|.:.|.|....|
Zfish   833 GIQVAKEMAQKELSEQKSLYEIKIRALERELKEESERKREQELHKQRAASQIEQLQSVKTLLEKE 897

  Fly   696 SCWTAREAGLAAWAFRK------WRYHQFTS--------LRDDL--------------------- 725
            .....|...:.|.|.|:      .|:.:..:        :.:||
Zfish   898 VSSHKRRLQMEAQATRQAMADHDVRHAKIVAALEAEKRKIAEDLAQIEMKRALKVTQTPKMAIPQ 962

  Fly   726 WGN---AIFLKEANAISVELKKKVQFQFTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKTL 787
            |..   ::.::|||.||.:|:|...|                  |......:|.|.|     ...
Zfish   963 WDAMKLSLMIEEANKISGKLRKHTVF------------------SRHEAADKEVEGG-----DAQ 1004

  Fly   788 VAVEVTDTKNGATHHWSLEKLRYRLELMRQIYNVES----------------PPSSMLFDTSGM- 835
            :.|:|.:||.|.:..|||||.:..|..||:|...||                |..|....||..
Zfish  1005 LQVQVQNTKLGISTFWSLEKFQSNLAAMREIEQGESASKDDDVFYDPNDEWEPDLSASSSTSSFS 1069

  Fly   836 ----------EALSGWI-----------------------SPPSQH--------PG--------Q 851
                      ..:||.:                       .|||.|        ||        .
Zfish  1070 RRRSRSLLKSRRISGRLYEIRVHPIQSLHCTPSQSTGLMNKPPSLHSSTSDSALPGICKDLIGSA 1134

  Fly   852 QAQLLPLEPPVESE--RGRLTLANLIPSRQRLELMREMYH-----NEAEMSPTSPDYNVESLTGG 909
            .|:|...:...|||  ..:||| :|:...:.:..:.::|.     :|..:...|.:.... |...
Zfish  1135 VARLRSCQSADESESLADKLTL-DLLSVHRAVRAITDLYEDLDDDSEENLFACSTEAQTH-LVKA 1197

  Fly   910 DPFYDRFPWFRMVGRSFIYLSNLLYPVPLVHKVAIVNERGD--------VRGYLRIAVQPVLDEE 966
            ....:|..:..|...|.|...::           .|::|.:        :.|||::.:|....|.
Zfish  1198 TSAVERAVFITMHWVSSITFGSI-----------TVSQRAEELKMEVKKIGGYLQLLIQGCDSEI 1251

  Fly   967 S---IDFNNGVKQSARLVF---------NEDDAKPKYRALNEKDDVQRYIDNGGL-----DSKLE 1014
            |   .:....|.:....||         |..|..     |||::  ...|||..:     |...:
Zfish  1252 SSMVTEARKRVAECMNAVFKTIGFLAAVNGTDLH-----LNEQN--SEIIDNRSIVDCLQDGMRQ 1309

  Fly  1015 ELEDVDS-GRGIDSNSASECHENSEEPGEHLQVGK 1048
            .::|:.| |..:........|     .|..||:.|
Zfish  1310 SVKDLLSVGLLVTEEMLQVSH-----TGSTLQISK 1339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	179/366 (49%)
		KISc	3..358	CDD:214526	178/365 (49%)
		Kinesin_assoc	355..498	CDD:292801	56/145 (39%)
		FHA	475..574	CDD:238017	50/98 (51%)
		KIF1B	878..923	CDD:289208	6/49 (12%)
		DUF3694	1246..1347	CDD:289256
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
		PH	1607..1700	CDD:278594
kif14	XP_005170522.1	KISc	235..586	CDD:214526	178/365 (49%)
		KISc_KIF1A_KIF1B	236..586	CDD:276816	178/364 (49%)
		Kinesin_assoc	583..701	CDD:292801	55/144 (38%)
		FHA	681..778	CDD:238017	49/96 (51%)
		Prefoldin	806..878	CDD:298833	22/71 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820