Protein Alignment unc-104 and kif11

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: NP_001016116.2
• Gene: kif11 / 548870
• XenbaseID: XB-GENE-978999
• Length: 1067
• Species: Xenopus tropicalis
• Alignment Length: 1201
• Identity: 281/1201 - (23%)
• Similarity: 475/1201 - (39%)
• Gaps: 311/1201 - (25%)

  Fly     3 SVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSHDHHDADF 67
            :::|.||.||||..|....|..::|.......:.......|.....|.:.||..:       ...
 Frog    18 NIQVVVRCRPFNQLERKASSHSVLECDAPRKEVCVRTGGINDKLGKKTYTFDMVF-------GPA 75

  Fly    68 STQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQE---------GIIPMIC 123
            :.|..||:.:...:|.....|||..:|||||||.||::||.|.:...:|         ||||...
 Frog    76 AKQIDVYRSVVCPILDEVIMGYNCTVFAYGQTGTGKTFTMEGERSADEEFTWEQDPLAGIIPRTL 140

  Fly   124 KDLFTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPK-NKG-NLRVREHP--LLGPYVEDLSKL 184
            ..:|.::.:..|:   :||:||.:|||.|.:.|||:|. :.| .|::.:.|  ..|..::.|.::
 Frog   141 HQIFEKLSENGTE---FSVKVSLLEIYNEELFDLLSPSPDVGERLQMFDDPRNKRGVIIKGLEEV 202

  Fly   185 AVTDYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTE---KVSKISL 246
            :|.:..:::.:::.|...|..|:|.||..|||||:||::..    |...|.:..|   |:.|::|
 Frog   203 SVHNKDEVYHILERGAARRKTASTLMNAYSSRSHSVFSVTI----HMKETTVDGEELVKIGKLNL 263

  Fly   247 VDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWL 311
            |||||||....:||...|.:|..|||:||.|||:||:||.|         :|..||||:|.||.:
 Frog   264 VDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVE---------RAPHIPYRESKLTRI 319

  Fly   312 LRENLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAK-LIRELKEEIQK 375
            |:::|||.:||::||.:|||.||.:||:|||.||:|||.|:.|..||:....: ||:|..|||::
 Frog   320 LQDSLGGRTKTSIIATVSPASINLEETVSTLEYANRAKNIMNKPEVNQKLTKRALIKEYTEEIER 384

  Fly   376 L-RDLLKA----------------EGIEVQEEDELT----KSTVIKSPTKSRN----RNGSTTEM 415
            | |||..|                :|..:.:|:.:|    |.|.::...|..|    .|....|.
 Frog   385 LKRDLATAREKNGVYLSNENYEQLQGKVLSQEEIITEYTEKITAMEEEIKRINELFAENKKELEE 449

  Fly   416 AVDQLQASEKLIAELN--------------------ETWEEKLKRT------------------- 441
            ....||..||.:.|..                    ||.|:||..|
 Frog   450 CTTILQCKEKELEETQKNLHESKEQLAQEAFVVTALETTEKKLHGTANKLLTTVRETSKDVSGLH 514

  Fly   442 ---------EEIRVQREAVFAEM-------------GVAVKEDGI-----------------TVG 467
                     ::...|....|||.             ..:||:.|:                 .:.
 Frog   515 AKLDRKRAVDQHNTQVHENFAEQMNKRFSVIERSVDEYSVKQQGMLDFYTNSIDDLLGASSAALS 579

  Fly   468 VFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLSGSHILKEHCTFENKNST 532
            |.:........::.|  .:||.:.:.:.| :.:..|..:....|:|    .::..|.|...:...
 Frog   580 VTATAVAKSFTSVQE--TVSEKVSHSVDE-ILKQETLSSQAKDDLQ----KLMAAHRTGLEQALR 637

  Fly   533 VTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQARELRDKIETENEAENEVEK 597
            ..|||...|::.:|                    :|:.......||  :.|||::..|..|....
 Frog   638 TDLLPVVTAVLNLN--------------------SHLSHCLQNFQA--VADKIDSHKEEMNSFFT 680

  Fly   598 TDTQQVDWNFAQCELLEKQGIDLKAEMKKRLDNLEEQYKREKLQADQQFEEQRKTYEARIDALQK 662
            ..::.:.              .|:.:....|.:::.:|:..|::.:.......:.....|.:||.
 Frog   681 EHSRSLH--------------RLRLDSGSALSSIQSEYESLKVEIETAQSMHSEGVNNLIGSLQN 731

  Fly   663 QVEEQSM-TMSMYSSYSPEDFHQEEDVYTNPMYESCWTAREAGLAAWAFRKWRYHQFTSLRDDLW 726
            |:...:| |...:|.:..:....::.|       .|.......:::.|.      :.||...|.
 Frog   732 QLNLLAMETQQNFSGFLAKGGKLQKSV-------GCLQQDLDSISSDAI------EHTSSHHDK- 782

  Fly   727 GNAIFLKEANAISVELKKKVQFQFTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSK---TLV 788
                |..::..|:||:::........|.::  |....:|..::..:.:|.:......|:   :|:
 Frog   783 ----FAGQSQDIAVEIRQLAASNMGTLEES--SKQCEKLTGSINAISRESQHWCESASQQIDSLL 841

  Fly   789 AVEVTDTKNGATHHWSLEKLRYRLELMRQIYNVE-SPPSSMLFDTSGMEALSGWISPPSQHPGQQ 852
            ..:|...:....|..||:|            :|| ...:|::..|..:.|         |...::
 Frog   842 EEQVCYLRTSKKHLQSLQK------------DVEVGCGASVVEITEHVNA---------QRQAEE 885

  Fly   853 AQLLPLEPPVESERGRLTLANLIPSRQRLELMREMYHNEAEMSPTSPDYNVESL-----TGGDPF 912
            ..|..|...|..::..|       ..|||||..::...:.:::    .|..|.|     ||..|
 Frog   886 KALTSLVEQVRDDKEML-------GEQRLELHEQVQSGQNKVN----SYLNEELRNDVPTGTTP- 938

  Fly   913 YDRFPWFRMVGRSFIYLSNLLYPVPLVHKVAIVNERGDVRGYLRI-------AVQPVLDEESIDF 970
                     ..|.::|.|.|:...|  ..|.:...|...:.||..       ||:|.::::|:
 Frog   939 ---------QRRDYVYPSLLVRTKP--RDVLLEQFRQQQQEYLESISSVISEAVEPPVEQDSL-- 990

  Fly   971 NNGVKQSARLVFNEDDAKPKYRALNEKDDVQRYIDNGGLDSKLEELEDVDSGRGIDSNSASECHE 1035
                          :|..|.  |:|              ||.:.|...:|        .:..|.|
 Frog   991 --------------EDEPPV--AVN--------------DSVMSEKSCID--------LSMVCQE 1017

  Fly  1036 NSEEP----GEHLQVGKEFTFRVTVLQATGI 1062
            |...|    .:.|:..||.....|:|:.:.|
 Frog  1018 NGGVPFFQQKKALRKEKENRANTTLLERSKI 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	134/370 (36%)
		Kinesin_assoc	355..498	CDD:465047	45/246 (18%)
		FHA_KIF1	474..574	CDD:438757	15/99 (15%)
		YhaN	<575..>666	CDD:443752	15/90 (17%)
		KIF1B	878..924	CDD:463574	11/50 (22%)
		DUF3694	1199..1347	CDD:463599
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
kif11	NP_001016116.2	KISc_BimC_Eg5	16..368	CDD:276815	136/372 (37%)
		SMC_prok_B	376..>635	CDD:274008	46/265 (17%)
		sbcc	406..>915	CDD:129705	97/599 (16%)
		Microtub_bind	927..1066	CDD:464048	35/174 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1048..1067		1/1 (100%)