Protein Alignment unc-104 and KIF1A

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: XP_047300774.1
• Gene: KIF1A / 547
• HGNCID: 888
• Length: 1825
• Species: Homo sapiens
• Alignment Length: 1875
• Identity: 1007/1875 - (53%)
• Similarity: 1259/1875 - (67%)
• Gaps: 222/1875 - (11%)

  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSH-DHHDA 65
            :|||||||||||||||::|:|||||:|:|:||.|.|||.|..|.   |.|:|||||||| ...|.
Human     4 ASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETP---KSFSFDYSYWSHTSPEDI 65

  Fly    66 DFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLFTRI 130
            ::::|..||:|||||||||:|:||||||||||||||||||||||:||:.|:||||.:|:|||:||
Human    66 NYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDLFSRI 130

  Fly   131 QDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIHDL 195
            .||..|::.||||||||||||||||||||||||||||||||||||||||||||||||.|.||.||
Human   131 NDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDL 195

  Fly   196 IDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERADSTGA 260
            :|.|||||||||||||||||||||||.|.|||:|||..||:||||||||||||||||||||||||
Human   196 MDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERADSTGA 260

  Fly   261 KGTRLKEGANINKSLTTLGKVISALAEVAS---KKKNTKKADFIPYRDSALTWLLRENLGGNSKT 322
            |||||||||||||||||||||||||||:.|   |.|..||.||||||||.|||||||||||||:|
Human   261 KGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLGGNSRT 325

  Fly   323 AMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGI-- 385
            ||:||:|||||||||||||||||||||||.|.||:|||.|.|||||||:|:.:|||||.|:|:
Human   326 AMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGD 390

  Fly   386 --------------------------EVQEEDE----LTKSTVIKSPTKSRNRNGST-------- 412
                                      .|.|..:    :|.:.|..||:.|.:...|.
Human   391 ITDTNTVPGGPKYVSDLENNNLNRGGTVNEAPDPLSTVTNALVGMSPSSSLSALSSRAASVSSLH 455

  Fly   413 --------TEMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQREAVFAEMGVAVKEDGITVGVF 469
                    :|.|:::|:.:||:||||||||||||:|||.||::|||:.||||||::|||.|:|||
Human   456 ERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVF 520

  Fly   470 SPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLSGSHILKEHCTFEN-----K 529
            |||||||||||||||.:|||||||||:|:||:|..:....|||.|||..|.:|||.|.:     .
Human   521 SPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGS 585

  Fly   530 NSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQARELRDKIETENEAENE 594
            .:.|||.|.:.|..||||:|:.||.:|::|:|:|:||:|||||.:|||||:.|::        ..
Human   586 EAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERER--------TP 642

  Fly   595 VEKTDTQQVDWNFAQCELLEKQGIDLKAEMKKRLDNLEEQYKREKLQADQQFEEQRKTYEARIDA 659
            ..:|..:.|||.|||.|||||||||:|.||::||..||:||:||:.:|....|:||..||::::|
Human   643 CAETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEA 707

  Fly   660 LQKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNPMYESCWTAREAGLAAWAFRKWRYHQFTSLRDD 724
            ||||::         |.|.||...:||:    |..|..||.||..||.||||||:::|||||||.
Human   708 LQKQMD---------SRYYPEVNEEEEE----PEDEVQWTERECELALWAFRKWKWYQFTSLRDL 759

  Fly   725 LWGNAIFLKEANAISVELKKKVQFQFTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKTLVA 789
            ||||||||||||||||||||||||||.||||||||||||:|....|...:|..    |..:|:||
Human   760 LWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETR----PFPRTIVA 820

  Fly   790 VEVTDTKNGATHHWSLEKLRYRLELMRQIYN-VESPPSSMLFDTS-------------------G 834
            |||.|.||||||:|:|||||.||:|||::|: ....|||::.|..                   |
Human   821 VEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDRFPWFRLVG 885

  Fly   835 MEALSGWISPPSQHPGQQAQLLPLEP-PVESERGRLTLANLIPSRQRLELMREM-YHNEAEMSPT 897
            ..|:||..|.|..:.....::..|.| |..|.          |.....|...|. ...|.|....
Human   886 SSAISGCNSYPLLNTCMSERMAALTPSPTFSS----------PDSDATEPAEEQSVGEEEEEEEE 940

  Fly   898 SPDYNVESL-----------TGGDPFYDRFPWFRMVGRSFIYLSNLLYPVPLVHKVAIVNERGDV 951
            ..|...|.|           .|.||||||.|.|.:|||:|:|||||||||||||:||||:|:|:|
Human   941 EEDEEEEDLEDDVFPEHALCDGRDPFYDRPPLFSLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEV 1005

  Fly   952 RGYLRIAVQPV-LDEESIDFNNGVKQS--ARLVFNEDDAKPKYRALNEKDDVQRYIDNGGLDSKL 1013
            :|:||:|||.: .|||:.|:.:||:||  |::.| :|....|::  :|...|.....:|   :..
Human  1006 KGFLRVAVQAISADEEAPDYGSGVRQSGTAKISF-DDQHFEKFQ--SESCPVVGMSRSG---TSQ 1064

  Fly  1014 EELEDVD-SGRGID-SNSASECHEN--------------SEEPG---------EHLQVGKEFTFR 1053
            |||..|: .|:|.| ..||.|.:.|              ||:..         :||::|..||||
Human  1065 EELRIVEGQGQGADVGPSADEVNNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFR 1129

  Fly  1054 VTVLQATGIGAEYADIFCQFNFLHRHEEAFSTEPVKNSASGAPLGFYHVQNITVPVTKSFIEYLK 1118
            ||||||:.|.||||||||||||:|||:|||||||:||:..|.||||||||||.|.||||||||:|
Human  1130 VTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIK 1194

  Fly  1119 TQPIMFKIFGHYQTHPLHKDAKQDFVSRPPPRRMLPPSIPISQPVRSPKFGPL--PC-APTSTVL 1180
            :|||:|::|||||.||.....|.......|.||..|..:|:|:||.:.|...|  || .|..
Human  1195 SQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCH--- 1256

  Fly  1181 AKHDVLVWFEICELAPNGEYVPSVVEHSDDLPCRGLFLLHQGIQRRIRITIVHEPTTEVKWKDIN 1245
            .|:|:||:||||||..||:|:|:||:|...:||.|.|||||||||||.:|::||..:.::||::.
Human  1257 CKYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVR 1321

  Fly  1246 ELVVGRIRNTPESSDEQDEDACVLSLGLFPGEALEVPGDD---------RSFYRFEAAWDSSLHN 1301
            |||||||||||| :||...|..:|||.:.....:....||         |:||:||||||||:||
Human  1322 ELVVGRIRNTPE-TDESLIDPNILSLNILSSGYIHPAQDDRQFLDSDIPRTFYQFEAAWDSSMHN 1385

  Fly  1302 SALLNRVSQGGETIYITLSAYLELENCARPAIITKDLSMVIYGRDAR-TGPRSLKHLF-SGQYRN 1364
            |.|||||:...|.||:|||||:|:|||.:||::|||..||.|.|||: ...||:::|| ||..|.
Human  1386 SLLLNRVTPYREKIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSGSLRA 1450

  Fly  1365 PEANRLTGVYELALRRASEAGSPGVQRRQRRVLDTSSTYVRGEENLHGWRPRGDSLIFDHQWELE 1429
            .|:||:||||||:|...::|||||:|||:|||||||..||||||||.|||||.||||.|||||||
Human  1451 SESNRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELE 1515

  Fly  1430 KLTRLEEVGRMRHLLLLRERLGMDTNPNPTTKT---EKDVCNLAARAATSPVHMVIPQSPQTPVK 1491
            ||:.|:||.:.||.|||||:|.....|.|...:   .:|..:..:.:|:||:.   .:...:|::
Human  1516 KLSLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSESHGSSSASSPLS---AEGRPSPLE 1577

  Fly  1492 DPQQIIPEREYNQREQDLMLKCLKLV----QGRYTKSEANDTQTQS-----------DVSPSDEG 1541
            .|         |:|:::|.:|||:|:    ...||.|....:.::|           |.|.|..|
Human  1578 AP---------NERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRDPSMSPLG 1633

  Fly  1542 CADMTVSCISSNSMENNKFVIRRRL---CS------PDRADAPNGWEAPAPATQPAL---PLRLY 1594
            .|.:|.|....:.:|........|.   ||      |:.....:..:.|:||.....   |.||.
Human  1634 VATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPELLPEADSKKLPSPARATETDKEPQRLL 1698

  Fly  1595 VPELEEIRVSPVVARKGLLNVLEHGGSGWKKRWVIVRRPYVFIYRSEKDPVERAVLNLATAHVEC 1659
            ||:::||||||:|::||.|:.||...|||.:|:|:|||||.::|.|:||.|||.|||||||.||.
Human  1699 VPDIQEIRVSPIVSKKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDKDTVERFVLNLATAQVEY 1763

  Fly  1660 SEDQAAMVKIPNTFSVVTKHRGYLLQTLGDKEVHDWLYAINPLLAGQIKSRLARR 1714
            ||||.||:|.||||:|.|:|||.|||...||::||||||.||||||.|:|:|:||
Human  1764 SEDQQAMLKTPNTFAVCTEHRGILLQAASDKDMHDWLYAFNPLLAGTIRSKLSRR 1818

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	287/359 (80%)
		Kinesin_assoc	355..498	CDD:465047	91/190 (48%)
		FHA_KIF1	474..574	CDD:438757	58/104 (56%)
		YhaN	<575..>666	CDD:443752	44/90 (49%)
		KIF1B	878..924	CDD:463574	17/57 (30%)
		DUF3694	1199..1347	CDD:463599	84/156 (54%)
		PH_KIFIA_KIFIB	1602..1704	CDD:269939	66/101 (65%)
KIF1A	XP_047300774.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	287/359 (80%)
		Kinesin_assoc	358..549	CDD:465047	91/190 (48%)
		FHA_KIF1A	525..639	CDD:438778	63/113 (56%)
		ERM_helical	658..>711	CDD:466641	29/52 (56%)
		KIF1B	839..886	CDD:463574	12/46 (26%)
		DUF3694	1275..1431	CDD:463599	84/156 (54%)
		PH_KIFIA_KIFIB	1706..1808	CDD:269939	66/101 (65%)