Protein Alignment unc-104 and Klp54D

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: NP_001303355.1
• Gene: Klp54D / 47216
• FlyBaseID: FBgn0263076
• Length: 760
• Species: Drosophila melanogaster
• Alignment Length: 689
• Identity: 192/689 - (27%)
• Similarity: 296/689 - (42%)
• Gaps: 151/689 - (21%)

  Fly     3 SVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSD-SVKRFNFDYSYWSHDHHDAD 66
            ::.|.|||||.|.:|........::..|      |.:|....:| ..||        ||:.....
  Fly   166 NINVVVRVRPLNDKEKRDRHGSTLQFPG------NGQVILEGNDVGQKR--------SHNRDSVR 216

  Fly    67 FSTQSMVYKD--IGEEMLQHS---------FDGYNVCIFAYGQTGAGKSYTMMG---------RQ 111
            ..|.::|::.  ..|::|.:|         .:|::...|.|||||:||::|:.|         ..
  Fly   217 VFTYNVVFEPGATQEDILDYSGIKRIIEMGIEGFSCTAFCYGQTGSGKTHTLTGPPDLFVGKPNP 281

  Fly   112 EEQQEGIIPMICKDLFTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLL-- 174
            ::.:.|:|......||..|::.:  |:.|.::.|:||||.|||.|||||   |:.|   .||.
  Fly   282 KDPRHGLIFRSFLYLFQLIKNRK--DVNYVLKASFMEIYNERVIDLLNP---GSAR---KPLAVR 338

  Fly   175 ------GPYVEDLSKLAVTDYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLM 233
                  |.:||:|..:...:..|:..:::||.:.|.|.:..||:.|||||.:.|:....   |..
  Fly   339 WSKKSGGFFVENLFTVDCEELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHILS---DQQ 400

  Fly   234 TN--LTTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTK 296
            |:  :...|..||:.|||||||....|.::|..|:|..||||||..||..||:|::      :.|
  Fly   401 TDGGVFLSKHGKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVLGYCISSLSD------SKK 459

  Fly   297 KADFIPYRDSALTWLLRENLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDA 361
            :...||||||.||.||.::|.||..|.|||.:|||..|:.|||:|||||.|||:|..|.|:..|.
  Fly   460 RTGHIPYRDSQLTKLLADSLAGNGVTLMIACVSPAHYNHAETLNTLRYASRAKRIRTKPVIKMDP 524

  Fly   362 NAKLIRELKEEIQKLRDLLKAEGIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKL 426
            ...||..||.:|..|:          .|.|.|..:..:......   ||...|..::
  Fly   525 REALILSLKRDIHALQ----------MENDHLKAALNLHHQAAP---NGGPVENLLE-------- 568

  Fly   427 IAELNETWEEKLKRTEEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLL 491
                               :|.:.|.:..||.|.:..:       ::.|.|    :...|:|.:.
  Fly   569 -------------------LQLDRVSSGGGVPVPKVDL-------QRLPEL----DGSELAELVK 603

  Fly   492 YYI--KEGLTRLGTHEANVPQDIQLSGSHILKEHCTFENKNSTVT-------LLPHKDAIIYVNG 547
            .|:  .|.|.:...|...|.:.|......:.:|:.....|...|.       |:|.:.||....|
  Fly   604 LYMVENESLRQENNHLFTVRETILRDQEIVCRENERLLKKLEDVNKVCVRSPLIPARPAISPTTG 668

  Fly   548 RKLVEPEVLKTGSRVILGKNHVFRFTNPE--QARELRDKIETENEAENEVEKTDTQQ--VDWN-- 606
            ::....|:                :||||  |:....|....:..:||...:|||.|  :|..
  Fly   669 KETPGTEI----------------WTNPEPLQSPPGPDLPIEQRMSENANRRTDTAQKRIDQKRI 717

  Fly   607 ----FAQCELLEKQGIDLKAEMKKRLDNLEEQYKREKLQ 641
                ........|...|:..|:..   |.||.:.::..:
  Fly   718 AKNILIMANAFRKPDSDITKELNL---NPEEAHAKQSTE 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	136/385 (35%)
		Kinesin_assoc	355..498	CDD:465047	25/144 (17%)
		FHA_KIF1	474..574	CDD:438757	19/108 (18%)
		YhaN	<575..>666	CDD:443752	17/77 (22%)
		KIF1B	878..924	CDD:463574
		DUF3694	1199..1347	CDD:463599
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	135/384 (35%)