DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unc-104 and Klp68D

DIOPT Version :9

Sequence 1:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster
Sequence 2:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	924	Identity:	258/924 - (27%)
Similarity:	407/924 - (44%)	Gaps:	230/924 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSHDHHDADFS 68
            |:|.||.||.::||.:..|..::.:......:....|.....:..|.|.:|.:|      ||. :
  Fly    20 VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAY------DAS-A 77

  Fly    69 TQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMG-RQEEQQEGIIPMICKDLFTRIQD 132
            ||:.:|.::...::....:|:|.|||||||||.||::||.| |..::..||||...:.::..|..
  Fly    78 TQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHINR 142

  Fly   133 TETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIHDLID 197
            ||  :.::.|:|||:|||.|.:||||.|.:| :|.|||.. .|.||.:|..:.....:|:..::.
  Fly   143 TE--NFQFLVDVSYLEIYMEELRDLLKPNSK-HLEVRERG-SGVYVPNLHAINCKSVEDMIKVMQ 203

  Fly   198 EGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERADSTGAKG 262
            .|||.|||..|||||.||||||:|.|..  ...|..||  |.||.|::|:|||||||...|||..
  Fly   204 VGNKNRTVGFTNMNEHSSRSHAIFMIKI--EMCDTETN--TIKVGKLNLIDLAGSERQSKTGASA 264

  Fly   263 TRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGNSKTAMIAA 327
            .||||.:.||.:|::||.|||||||         .:..:|||||.||.||:::|||||||.|||.
  Fly   265 ERLKEASKINLALSSLGNVISALAE---------SSPHVPYRDSKLTRLLQDSLGGNSKTIMIAN 320

  Fly   328 ISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGIEVQEEDE 392
            |.|::.||:|||:|||||.|||.|..:.:.|||.....::|.:|||::|:.|:..:..:..|:..
  Fly   321 IGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRLIGPQQQQRSEKQV 385

  Fly   393 LTKSTVIKSPTK-------SRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQREA 450
            ..|...:|.|.|       |.:...||.|..|:.....|...:|.::..|.::.::.| .::||.
  Fly   386 TAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVEDDSDPEGAESESDKENEAEVAKSNE-ELERER 449

  Fly   451 VFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLS 515
            | ....:|.|                         |:|.....::.|...|.|:.   .:.|:|.
  Fly   450 V-ENSKLAAK-------------------------LAELEGQLVRGGKNLLDTYS---ERQIELE 485

  Fly   516 GSHILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQARE 580
                                            :|||  |:.:...|.|                |
  Fly   486 --------------------------------KKLV--EIAERKKREI----------------E 500

  Fly   581 LRDKIETENEAENEVEKTDT---QQVDWN-------FAQCELLEKQGIDLKAEMKKRLDNLE--- 632
            ::.::|.:.|...|:.:.:.   |:|:..       :|:...|:::..|.|::..:.|..||
  Fly   501 IQQQLELQEETTLEIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQ 565

  Fly   633 ----EQYKREKLQADQ--QFEEQRKTY-EARIDALQKQVEEQSMTM-------SMYSSYSPEDFH 683
                ::.||:.|..|.  ..|.:::.| :|:.|..|::.:..||::       ..:||..|....
  Fly   566 NELVKELKRQLLIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHP 630

  Fly   684 QEEDVYTNPMYESCWTAREAGLAAWAFRKWRYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQF 748
            |                |....:.:|.::.:.:..:|||         .|..|.::.||:
  Fly   631 Q----------------RRRPTSEYALQEAKSNSPSSLR---------FKSENIVNYELE----- 665

  Fly   749 QFTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNGA-------THHWSLE 806
                                 .|.....|:..|.||.:|.||.....:.|.       :|   ..
  Fly   666 ---------------------MPCRTTQEYRTPKVSASLQAVLAQAMQTGGDDIDIVDSH---TN 706

  Fly   807 KLRYRLELMRQIYNVES-----PPSSMLFDTSGMEALSGWISPPSQHPGQQAQLLPLEPPVESER 866
            .||.|||   .|.|..:     |.:.:...:|                      :|....::|.|
  Fly   707 SLRSRLE---NIINANANGGAGPGAGVAVGSS----------------------IPNVRNIKSSR 746

  Fly   867 GRLTLANLIPSRQR 880
            |..:.|:.:.|.:|
  Fly   747 GLPSAASNLDSNRR 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	154/354 (44%)
		KISc	3..358	CDD:214526	154/354 (44%)
		Kinesin_assoc	355..498	CDD:292801	30/149 (20%)
		FHA	475..574	CDD:238017	13/98 (13%)
		KIF1B	878..923	CDD:289208	1/3 (33%)
		DUF3694	1246..1347	CDD:289256
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
		PH	1607..1700	CDD:278594
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	153/347 (44%)
		KISc	20..351	CDD:214526	154/354 (44%)
		GBP_C	<479..576	CDD:303769	23/146 (16%)
		coiled coil	547..558	CDD:293879	2/10 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437962
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940