Protein Alignment unc-104 and kif18a

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: NP_956533.1
• Gene: kif18a / 393209
• ZFINID: ZDB-GENE-040426-862
• Length: 895
• Species: Danio rerio
• Alignment Length: 904
• Identity: 261/904 - (28%)
• Similarity: 406/904 - (44%)
• Gaps: 189/904 - (20%)

  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNT---------SDSVKRFNFDYSY 57
            |.|||.|||||.|.:|.....|.::.:......:.:||....|         .|..||.|.|..:
Zfish     8 SHVKVVVRVRPLNDKEKDGNFKKVVHVVDNHMLVFDPKEEEVTFFRGQRVGNRDVRKRANKDLKF 72

  Fly    58 WSHDHHDADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMI 122
             ..|....:.|:|..|:::..:.::....:|||..:||||.|||||::||:|  .....|::.:.
Zfish    73 -VFDSVFGEESSQIEVFENTTKAIVDGVLNGYNCTVFAYGATGAGKTHTMLG--TSNSPGVMFLT 134

  Fly   123 CKDLFTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVT 187
            .|:||.|: |...:|..::|..||:|:|.|::||||.  |.|.|.|||....|..|:.|:.....
Zfish   135 MKELFARM-DLIKEDKVFNVAFSYLEVYNEQIRDLLT--NSGPLAVREDGSNGVVVQGLTLHQPK 196

  Fly   188 DYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTE-KVSKISLVDLAG 251
            ..:.|.:.:|.||:.||...|:||.|||||||||.|:.  |:.|...:|... :|:|:||:||||
Zfish   197 SAEHILEALDYGNRNRTQHPTDMNATSSRSHAVFQIYL--RQQDKTASLNPNVRVAKMSLIDLAG 259

  Fly   252 SERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENL 316
            ||||.:|..||.||:||||||:||..||.||:.||....||.:      ||||||.||.||:::|
Zfish   260 SERASATNTKGARLREGANINRSLLALGNVINTLANPKCKKTH------IPYRDSKLTRLLKDSL 318

  Fly   317 GGNSKTAMIAAISPADINYDETLSTLRYADRAKQI---VCKAVVNEDAN----AKLIRELKEEIQ 374
            |||.:|.|||.:||:.::|::|.:||:||:|||:|   :...|::.|::    |.:..:.|.||.
Zfish   319 GGNCRTVMIANVSPSSLSYEDTHNTLKYANRAKEIKSTLRSNVMSLDSHIGQYAIICEKQKAEIV 383

  Fly   375 KLRDLLKAEGIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLK 439
            .|:..||    |.:|.         |:...:.|      .:::.:....||:...|...:.::||
Zfish   384 MLKQKLK----EYEER---------KAEAPALN------PISIQKRAEFEKMSESLRSVFSDRLK 429

  Fly   440 -RTEEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDP-NLSECLLYYIKEGLTRLG 502
             |.|.:.::::         :.|..:|:   ..:::.|..:|...| |.:|......:..|..|.
Zfish   430 LRKEHLDIEKQ---------LNESRLTM---RHRESWHQQSLIFFPDNKAERATCKYERKLASLK 482

  Fly   503 THEANVPQDIQLSGSHILKEHCTFENK------NSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSR 561
            :|:.::.|.:..|      |.|..||:      .:.:.||.|       :|.   .||.||...:
Zfish   483 SHQEHLQQRLMES------EKCFQENEGWLHRIENEMKLLGH-------DGH---TPEELKKELQ 531

  Fly   562 VILGKNHVFRFTNPEQARELRDKIETENE--AENEVEKTDTQQ-VDWNFAQCELLEKQGIDLKAE 623
            .     |..:.    |..:|:..:|..:.  :..:.|.|.|.: |:...:.|   .:|.:.|||.
Zfish   532 C-----HQLQL----QISDLQQHMEHMSHLISVQDQENTHTHKLVNALLSTC---RRQHLALKAM 584

  Fly   624 MK----KRLDNLEEQYKREK--LQADQQFEEQRK-------TYEARIDALQKQVEEQSMTMS--- 672
            ..    ...:.||....||:  :.|||:..|.::       |:...|.:....|..||...|
Zfish   585 SADGDGSEWEELERLVHRERAVVWADQEKAEDKRDDSGIGSTHLRPILSFSHLVSHQSTPCSSEK 649

  Fly   673 --------MYSSYSPED---FHQ---EEDVYTNPMYE--SCWTAREAG----LAAWAFRKWRYHQ 717
                    :..::|.:|   .||   .|.|...|:..  |...|:..|    |:         |.
Zfish   650 HTRRTSQRLRPTHSSKDCGPHHQVAEAEGVLKKPIRRKLSVSPAKLDGDGPVLS---------HH 705

  Fly   718 FTSLRDDLWGNAIFLKEANAISVELKKKVQFQFT----LLTDTLYSPLPPELASTVAPVHQEDEF 778
            ...|:|.|....:|               ..|||    ..|.:::.|     .||:...|.||..
Zfish   706 PPDLQDVLRQEGMF---------------PLQFTPEGQPHTSSIFDP-----NSTIDIGHIEDPT 750

  Fly   779 GA---------PPVSKTLVAVEVTDTKNGATHHWSLEKLRYRLELMRQIYNVESPPSSM 828
            ||         .|...||.|:...:....|.          |||:...:....|.||.|
Zfish   751 GANATIILSPEDPGRSTLQALRANNANKPAN----------RLEIPSLLDLRRSKPSYM 799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	151/368 (41%)
		Kinesin_assoc	355..498	CDD:465047	27/148 (18%)
		FHA_KIF1	474..574	CDD:438757	23/106 (22%)
		YhaN	<575..>666	CDD:443752	23/106 (22%)
		KIF1B	878..924	CDD:463574
		DUF3694	1199..1347	CDD:463599
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
kif18a	NP_956533.1	KISc_KIP3_like	9..353	CDD:276821	148/357 (41%)
		SMC_N	<345..572	CDD:481474	58/282 (21%)