DRSC/TRiP Functional Genomics Resources

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Protein Alignment unc-104 and KIF3C

DIOPT Version :10

Sequence 1:NP_611155.3 Gene:unc-104 / 36876 FlyBaseID:FBgn0267002 Length:1739 Species:Drosophila melanogaster
Sequence 2:NP_002245.4 Gene:KIF3C / 3797 HGNCID:6321 Length:793 Species:Homo sapiens


Alignment Length:938 Identity:244/938 - (26%)
Similarity:406/938 - (43%) Gaps:223/938 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SVKVAVRVRPFNSREIARESKCIIEM---AGATTAITNPKVPPNTSDSVKRFNFDYSYWSHDHHD 64
            ::||..|.||.:.:|.|...:.|:.|   .|..| :.||:..|  .:..|.|.||..|      |
Human    10 ALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVT-LRNPRAAP--GELPKTFTFDAVY------D 65

  Fly    65 ADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGR-QEEQQEGIIPMICKDLFT 128
            |. |.|:.:|.:....::.....|:|..:|||||||.||:|||.|. .|.:..|:||...:.:||
Human    66 AS-SKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFT 129

  Fly   129 RIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIH 193
            .|  :.:.:.:|.|..||:|||.|.:||||:.:....|.::|:|..|.|::|||.....:.::|.
Human   130 HI--SRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVTKNVKEIE 192

  Fly   194 DLIDEGNKARTVAATNMNETSSRSHAVF--TIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERAD 256
            .:::.||:.|.|.:|:|||.||||||:|  |:..::|..|...::   :|.|::|||||||||.:
Human   193 HVMNLGNQTRAVGSTHMNEVSSRSHAIFIITVECSERGSDGQDHI---RVGKLNLVDLAGSERQN 254

  Fly   257 ST------------------------GAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKK 297
            ..                        ||.|.|.||.:.||.||:.||.||:|||        ..:
Human   255 KAGPNTAGGAATPSSGGGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALA--------GNR 311

  Fly   298 ADFIPYRDSALTWLLRENLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDAN 362
            :..||||||.||.||:::||||:||.|:|.:.||..:|||:|||||:|:|||.|..|..||||..
Human   312 STHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPK 376

  Fly   363 AKLIRELKEEIQKLRDLLKAEGIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLI 427
            ..|:||.:|||.:|:..|:..|:            :.|.|.:..:|                   
Human   377 DTLLREFQEEIARLKAQLEKRGM------------LGKRPRRKSSR------------------- 410

  Fly   428 AELNETWEEKLKRTEEIRVQREAVFAEMG----------VAVKEDGITVGVFSPKKTPHLVNLNE 482
                               :::||.|..|          ||.:||........|:  |.|     
Human   411 -------------------RKKAVSAPPGYPEGPVIEAWVAEEEDDNNNNHRPPQ--PIL----- 449

  Fly   483 DPNLSECLLYYIKEGLTRLGTHEANVPQDIQLSGSHILKEHCTFENKNSTVTLLPHKDAIIYVNG 547
            :..|.:.:..|::|...||...:|.:..|..|          ..|.|..   ||..|:.::....
Human   450 ESALEKNMENYLQEQKERLEEEKAAIQDDRSL----------VSEEKQK---LLEEKEKMLEDLR 501

  Fly   548 RKLVEPEVLKT-----GSRVILGKNHVFRFTNPEQ------ARELRDKIETENEAENEVEKTDTQ 601
            |:....|:|..     .|::::|..::...||.:|      .:|:.::...|.|.:.|:...|.:
Human   502 REQQATELLAAKYKAMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMMLRDEE 566

  Fly   602 QVDWNFAQCELLEKQGIDLKAEMKKRLDNLEEQYKREKLQADQQFEEQRKTYEARIDALQKQVEE 666
            .::.......|  :|.:::|.   |:|..|..:.:..|.:...|.:|..:..:...:|..:|..|
Human   567 TMELRGTYTSL--QQEVEVKT---KKLKKLYAKLQAVKAEIQDQHDEYIRVRQDLEEAQNEQTRE 626

  Fly   667 QSMTMSMYSSYSPEDFHQEEDVYTNPMYESCWTAREAGLAAWAFRKWRYHQFTSLRDDLWGNAIF 731
            ..:...:..::.|.   :|::...|.::..|           ...:|::..              
Human   627 LKLKYLIIENFIPP---EEKNKIMNRLFLDC-----------EEEQWKFQP-------------- 663

  Fly   732 LKEANAISVELKKKVQFQFTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTK 796
            |..|...|.::||:                |........|:.|        .::..:|:      
Human   664 LVPAGVSSSQMKKR----------------PTSAVGYKRPISQ--------YARVAMAM------ 698

  Fly   797 NGATHHWSLEKLRYRLEL---------MRQIYNVESPPSSMLFDTSGMEALSGWISPPSQHPGQQ 852
             |:...:..|.:.: |||         |...::.|..|.::..:.  :..|..::..||....::
Human   699 -GSHPRYRAENIMF-LELDVSPPAVFEMEFSHDQEQDPRALHMER--LMRLDSFLERPSTSKVRK 759

  Fly   853 AQ---LLPLEPPVESERGRLTLANLIPS 877
            ::   ..|..||..:....|..|:|.|:
Human   760 SRSWCQSPQRPPPSTTHASLASASLRPA 787

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-104NP_611155.3 KISc_KIF1A_KIF1B 2..358 CDD:276816 147/384 (38%)
Kinesin_assoc 355..498 CDD:465047 30/152 (20%)
FHA_KIF1 474..574 CDD:438757 20/104 (19%)
YhaN <575..>666 CDD:443752 17/96 (18%)
KIF1B 878..924 CDD:463574 244/938 (26%)
DUF3694 1199..1347 CDD:463599
PH_KIFIA_KIFIB 1602..1704 CDD:269939
KIF3CNP_002245.4 KISc_KIF3 9..365 CDD:276822 145/377 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 251..288 6/36 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 394..424 9/79 (11%)
Smc <452..>635 CDD:440809 38/200 (19%)
Globular. /evidence=ECO:0000255 630..793 32/220 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 750..793 9/38 (24%)
Blue background indicates that the domain is not in the aligned region.

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