DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unc-104 and Klp59D

DIOPT Version :9

Sequence 1:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster
Sequence 2:	NP_611762.1	Gene:	Klp59D / 37674	FlyBaseID:	FBgn0034827	Length:	729	Species:	Drosophila melanogaster

Alignment Length:	483	Identity:	154/483 - (31%)
Similarity:	236/483 - (48%)	Gaps:	74/483 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNP---KVPPNTSDSVKRFNFDYSYWSHDH 62
            :..:.|.||.||.:.:|...::..||.:..|.:.|.:.   ||.........:|.|||::
  Fly   231 VQQITVCVRKRPMSRKEENSKNLDIITVPSADSLIVHELRLKVDLTKFLEHHKFRFDYTF----- 290

  Fly    63 HDADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTM----MGRQEEQQEGIIPMIC 123
             |.:.| .::||......:::..|:|.|...|||||||:||::||    .|:.::...||..|..
  Fly   291 -DEECS-NALVYDHTARPLIRTMFEGGNATCFAYGQTGSGKTHTMGGEFFGKVQDCGTGIYAMAA 353

  Fly   124 KDLFTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTD 188
            :|:|..:...|...:...:..|:.|||..:|.|||.| ||..|||.|.......|..|:::.||.
  Fly   354 RDVFEEVSRPEYRQMGAKITCSFFEIYGTKVFDLLLP-NKPMLRVLEDARQQVVVVGLTEMPVTK 417

  Fly   189 YQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFF----TQRRHDLMTNLTTEKVSKISLVDL 249
            .:|:..||:.|:|.||...|:.|..||||||||.|..    :...|           .|.|.|||
  Fly   418 VEDVLRLIEHGSKERTSGQTSANAKSSRSHAVFQIALHFPDSWGPH-----------GKCSFVDL 471

  Fly   250 AGSER-ADSTGA-KGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLL 312
            ||:|| ||:..| :.||: |||.|||||..|.:.|.||         ::::..:|:|.|.||.:|
  Fly   472 AGNERGADTQSADRQTRI-EGAEINKSLLALKECIRAL---------SRQSSHLPFRGSKLTQVL 526

  Fly   313 RENL--GGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIR-------E 368
            |::.  |..:||.|||.|||:....:.||:|||||||.|:::.|    ||.:.:.:.       :
  Fly   527 RDSFVGGKKNKTCMIAMISPSMSCVENTLNTLRYADRVKELIAK----EDEHLQSVEGDGEKSPD 587

  Fly   369 LKEEIQKLRDLLKAEGIEVQEEDELTKSTVIKSPTKSRNRN--------------GSTTEMAVDQ 419
            |.||.:.  :::..|..:.:.|||..:...|.|...|...|              |.:..:.:.:
  Fly   588 LNEESEP--EMMADEEGDEEPEDEDNQHLTISSEEASSYNNMSYDMSFNHTLNILGPSRNVDIQE 650

  Fly   420 LQASEKLIAELNETWE---EKLKRTEEI 444
            :.....|:.|..||:.   .:||..:||
  Fly   651 VAEQHALLVENLETYAHNFRQLKTDKEI 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	132/370 (36%)
		KISc	3..358	CDD:214526	132/369 (36%)
		Kinesin_assoc	355..498	CDD:292801	22/114 (19%)
		FHA	475..574	CDD:238017
		KIF1B	878..923	CDD:289208
		DUF3694	1246..1347	CDD:289256
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
		PH	1607..1700	CDD:278594
Klp59D	NP_611762.1	KISc_KIF2_like	233..565	CDD:276818	130/360 (36%)
Klp59D	NP_611762.1	Kinesin	239..566	CDD:278646	128/355 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437806
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940