Protein Alignment unc-104 and kif1b

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: XP_068072796.1
• Gene: kif1b / 369190
• ZFINID: ZDB-GENE-030820-1
• Length: 1927
• Species: Danio rerio
• Alignment Length: 1983
• Identity: 1013/1983 - (51%)
• Similarity: 1265/1983 - (63%)
• Gaps: 336/1983 - (16%)

  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSH-DHHDA 65
            :|||||||||||||||..:||||||:|.|.:|.|.|||.|...    |.|:|||||||| ...|.
Zfish     4 ASVKVAVRVRPFNSRETGKESKCIIQMQGNSTTILNPKNPKEP----KTFSFDYSYWSHTSPDDP 64

  Fly    66 DFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLFTRI 130
            .|::|:.||.|||:|||||:|:||||||||||||||||||||||:|||.||||||.:|::||.:|
Zfish    65 SFASQNQVYNDIGKEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEEGQEGIIPQLCEELFEKI 129

  Fly   131 QDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIHDL 195
            .|...:::.|||||:||||||||||||||||||||||||||||||||||||||||||.|.||.||
Zfish   130 NDNNNEEISYSVEVAYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADL 194

  Fly   196 IDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERADSTGA 260
            :|.|||||||||||||||||||||||||.||||::|..|:|:|||||||||||||||||||||||
Zfish   195 MDAGNKARTVAATNMNETSSRSHAVFTIVFTQRKYDSETDLSTEKVSKISLVDLAGSERADSTGA 259

  Fly   261 KGTRLKEGANINKSLTTLGKVISALAEV---ASKKKNTKKADFIPYRDSALTWLLRENLGGNSKT 322
            ||||||||||||||||||||||||||||   .||.|..||.||||||||.|||||||||||||:|
Zfish   260 KGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRT 324

  Fly   323 AMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEG--- 384
            ||:||:||||||:||||||||||||||||.|.||:|||.||||:||||:|:.:|::||:|:|
Zfish   325 AMVAALSPADINFDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKDEVSRLKELLRAQGLGD 389

  Fly   385 ---IEVQEED----------------------------------------------ELTKSTVIK 400
               ||...:|                                              .|.....::
Zfish   390 ILDIEPMGDDCLGSGSKYLKDIHNNKHRYLLASENQRPGHFSTAPMGCLTASPSSGSLCSQAGLQ 454

  Fly   401 SPTKSRNRNGSTT--EMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQREAVFAEMGVAVKEDG 463
            |.:..:.|..||.  |.|:::|:.|||:||||||||||||::||.||::|||:.||||||::|||
Zfish   455 SVSSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDG 519

  Fly   464 ITV------------------------------------------GVFSPKKTPHLVNLNEDPNL 486
            .|:                                          ||||||||||||||||||.:
Zfish   520 GTLGVFSPKKFGPDRPTSLSIEDFSVYSSNQLFVERPCEVYTDFNGVFSPKKTPHLVNLNEDPLM 584

  Fly   487 SECLLYYIKEGLTRLGTHEANVPQDIQLSGSHILKEHCTFENKNST-----VTLLPHKDAIIYVN 546
            |||||||||:|:||:|..:|...|||.|||:||.:|||.|.::.:.     |||.|.:.:..|||
Zfish   585 SECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERNANGHVIVTLEPCEGSETYVN 649

  Fly   547 GRKLVEPEVLKTGSRVILGKNHVFRFTNPEQARELRDKIETENEAENEVEKTDTQQVDWNFAQCE 611
            |:::.....|::|:|:|:||||||||.:|||||..|:|..:   ||..||     .|||.|||.|
Zfish   650 GKRVNSAVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPS---AETPVE-----PVDWTFAQRE 706

  Fly   612 LLEKQGIDLKAEMKKRLDNLEEQYKREKLQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSS 676
            ||||||||:|.||:|||..:|..||:||.:|||..|:||..||:::..||||||.:|:     ::
Zfish   707 LLEKQGIDMKQEMEKRLTEMEILYKKEKEEADQLLEQQRLVYESKLQELQKQVETRSL-----AA 766

  Fly   677 YSPEDFHQEEDVYTNPMYESCWTAREAGLAAWAFRKWRYHQFTSLRDDLWGNAIFLKEANAISVE 741
            .:|::..:||:....|     ||..:..||.||||||||||||||||.|||||::||||||||||
Zfish   767 ETPDEEEEEEEEDEVP-----WTQHKYELAQWAFRKWRYHQFTSLRDQLWGNAVYLKEANAISVE 826

  Fly   742 LKKKVQFQFTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNGATHHWSLE 806
            |||||||||.||||||||||||||    .|...|.|..|.|..:|:|||||.|.||||||:||||
Zfish   827 LKKKVQFQFVLLTDTLYSPLPPEL----LPPEPEKERDARPFPRTVVAVEVQDLKNGATHYWSLE 887

  Fly   807 KLRYRLELMRQIYNVESPPSSMLFDTSGMEALSG---------WI----SPPSQHPGQQAQLLPL 858
            ||:.||:.||::|:.....:|......|..||:|         |.    |.|..|.....:|...
Zfish   888 KLKQRLDQMREMYDRAGEMASSNQGDDGEGALTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADR 952

  Fly   859 EPPVESERGRLTLANLIPSRQRLELMREMYHNEAEMSPTSPDYNVES-----LTGGDPFYDRFPW 918
            .|..........:..|...||  ..|.:...:||.:..||.|...|.     ..|.||||||.||
Zfish   953 TPSPTFSTTDSEITELADERQ--SEMEDFMDDEAFVDDTSSDAGTEEGSDIFSDGQDPFYDRSPW 1015

  Fly   919 FRMVGRSFIYLSNLLYPVPLVHKVAIVNERGDVRGYLRIAVQPV-LDEESIDFNNGVKQS--ARL 980
            |.:|||:|:|||||||||||||:||:|.|:|||||:||:.||.: .|||:.|:.:||:||  |::
Zfish  1016 FILVGRAFVYLSNLLYPVPLVHRVAVVTEKGDVRGFLRVGVQAIAADEEAPDYGSGVRQSGTAKI 1080

  Fly   981 VFNEDDAKPKYRALNEKDDVQRYIDNGGLDSKLEELEDVDSGRGIDSNSASECHENSEEP----- 1040
            .|:.:..|       :.|.....:...||  .||||..|: |:|    .:||....|||.
Zfish  1081 SFDNEYFK-------KNDFTSVAMTRSGL--SLEELRIVE-GQG----QSSEVITPSEEMNRINE 1131

  Fly  1041 ----------------GEHLQVGKEFTFRVTVLQATGIGAEYADIFCQFNFLHRHEEAFSTEPVK 1089
                            .|||:||..||||||||||:||.||||||||||||||||:|||||||:|
Zfish  1132 MDLKLGNVDTKLGDGLAEHLEVGSIFTFRVTVLQASGIPAEYADIFCQFNFLHRHDEAFSTEPLK 1196

  Fly  1090 NSASGAPLGFYHVQNITVPVTKSFIEYLKTQPIMFKIFGHYQTHPLHKDAKQDFVS-RPPPRRML 1153
            |:..||||||||||||:|.||:|||||:||:||:|::|||||.||||... ||.|| ..|.|:..
Zfish  1197 NTGRGAPLGFYHVQNISVEVTESFIEYIKTKPIVFEVFGHYQQHPLHIHG-QDVVSPSQPSRKYY 1260

  Fly  1154 PPSIPISQPVRSPK----------------------------------------------FGPLP 1172
            ||.:|:|:|..:.|                                              |.|:|
Zfish  1261 PPPMPLSKPDHARKIELIRYLMSGYVHGQVLDTLSEHANALASTAVASLEEGAYELCHFPFLPIP 1325

  Fly  1173 CAPTSTV---------------------LAKHDVLVWFEICELAPNGEYVPSVVEHSDDLPCRGL 1216
            ..|...|                     ::|:|:|.||||.||.|.|||:|:||:|:..|||.|.
Zfish  1326 NCPVFRVPRHDVPATKLNTITKSNLGQCVSKYDLLAWFEISELEPTGEYIPAVVDHTGGLPCHGT 1390

  Fly  1217 FLLHQGIQRRIRITIVHEPTTEVKWKDINELVVGRIRNTPESSDEQDEDACVLSLGLFPGEALE- 1280
            :||||||||||.:|::||..:|:.|||:.|||||||||.|| .|:...|| ||||.:...:.|:
Zfish  1391 YLLHQGIQRRITVTLIHEKGSELHWKDVRELVVGRIRNKPE-VDDSAADA-VLSLNIISAKNLKS 1453

  Fly  1281 --------VPGD-DRSFYRFEAAWDSSLHNSALLNRVSQGGETIYITLSAYLELENCARPAIITK 1336
                    :..| .|:||||||.||||||||.|||||:..||.||:||||||||::|.:||||||
Zfish  1454 SHNSSSLCIDSDISRTFYRFEAVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPAIITK 1518

  Fly  1337 DLSMVIYGRDAR-TGPRSLKHLF-SGQYRNPEANRLTGVYELALRRASEAGSPGVQRRQRRVLDT 1399
            |:.||.|.|||: :.||||::|| ||..:.|:.|::||||||:|.:.::.||||:|||:|:||||
Zfish  1519 DICMVFYSRDAKISPPRSLRNLFGSGYSKTPDCNKVTGVYELSLCKIADTGSPGMQRRRRKVLDT 1583

  Fly  1400 SSTYVRGEENLHGWRPRGDSLIFDHQWELEKLTRLEEVGRMRHLLLLRERLGMDTNPNPTTKTEK 1464
            |..||||||||.||||||||||.:|||||:|:.:|.||.:.||||||||:||  ..|.|.:.:|.
Zfish  1584 SVAYVRGEENLAGWRPRGDSLILEHQWELDKMEQLHEVEKTRHLLLLREKLG--ETPPPKSLSES 1646

  Fly  1465 DVCNLA------ARAATSPVHMVIPQSPQTPVK-------DPQQIIPEREYNQREQDLMLKCLKL 1516
            ...:|:      :.:.:|.:.....:|..||.:       |.:.::      .||::|..|||:|
Zfish  1647 LSPSLSSGTLSTSTSISSQISSTTFESAITPSESSGYDSTDIESLV------DREKELATKCLRL 1705

  Fly  1517 VQGRYTKSEANDTQTQ------SDVSPSDEGCADMTVSCISSNSMENNKFVIRRRLCSPDRADAP 1575
            :...: .||.|.....      ||:||...   |.:||..||.::..:.      .| |..:|:.
Zfish  1706 LTHTF-NSEYNQMCNSISDCKFSDISPMGR---DPSVSSFSSATLTPSS------TC-PSLSDSR 1759

  Fly  1576 NGWEAPAPATQPA---------LP---------------LRLYVPELEEIRVSPVVARKGLLNVL 1616
            .. ||.:.||.|:         :|               |.| ||.:||:|...||::||:||.:
Zfish  1760 TP-EANSRATSPSGSDYENFPMVPILETSYLARAGKHEFLNL-VPNIEEMRPGSVVSKKGILNFM 1822

  Fly  1617 EHGGSGWKKRWVIVRRPYVFIYRSEKDPVERAVLNLATAHVECSEDQAAMVKIPNTFSVVTKHRG 1681
            |...:.|.|.:|:|||||||||.::||||||.||||:||.||.||||.||:|.|:||::.|||||
Zfish  1823 EPRSNTWVKHFVVVRRPYVFIYNNDKDPVERGVLNLSTAQVEYSEDQQAMLKTPHTFAMCTKHRG 1887

  Fly  1682 YLLQTLGDKEVHDWLYAINPLLAGQIKSRLARR 1714
            .|||...||:::|||||.||||||.|:|:||||
Zfish  1888 ILLQANNDKDMNDWLYAFNPLLAGTIRSKLARR 1920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	281/359 (78%)
		Kinesin_assoc	355..498	CDD:465047	89/238 (37%)
		FHA_KIF1	474..574	CDD:438757	57/104 (55%)
		YhaN	<575..>666	CDD:443752	50/90 (56%)
		KIF1B	878..924	CDD:463574	20/50 (40%)
		DUF3694	1199..1347	CDD:463599	91/157 (58%)
		PH_KIFIA_KIFIB	1602..1704	CDD:269939	62/101 (61%)
kif1b	XP_068072796.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	281/359 (78%)
		Kinesin_assoc	357..596	CDD:465047	89/238 (37%)
		FHA_KIF1B	571..680	CDD:438779	59/108 (55%)
		GBP_C	<680..754	CDD:293879	43/81 (53%)
		KIF1B	889..937	CDD:463574	12/47 (26%)
		KIF1B	<999..1021	CDD:463574	11/21 (52%)
		DUF3694	1373..1529	CDD:463599	91/157 (58%)
		PH_KIFIA_KIFIB	1808..1910	CDD:269939	62/101 (61%)