Protein Alignment unc-104 and Khc

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Alignment Length: 1262
• Identity: 308/1262 - (24%)
• Similarity: 495/1262 - (39%)
• Gaps: 385/1262 - (30%)

  Fly     3 SVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSV-----KRFNFDYSYWSHDH 62
            |:||..|.||.|..|....||.::            |.|.|..::.     |.:.||..:..:
  Fly    12 SIKVVCRFRPLNDSEEKAGSKFVV------------KFPNNVEENCISIAGKVYLFDKVFKPN-- 62

  Fly    63 HDADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMG-RQEEQQEGIIPMICKDL 126
                 ::|..||.:..:.::.....|||..|||||||.:||::||.| ..:..::||||.|..|:
  Fly    63 -----ASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDI 122

  Fly   127 FTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQD 191
            |..|...|. :|::.::|||.|||.:::||||: .:|.||.|.|.....|||:..::..|:..:|
  Fly   123 FNHIYAMEV-NLEFHIKVSYYEIYMDKIRDLLD-VSKVNLSVHEDKNRVPYVKGATERFVSSPED 185

  Fly   192 IHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEK--VSKISLVDLAGSER 254
            :.::|:||...|.:|.|||||.|||||:||.|...|.      ||..:|  ..|:.||||||||:
  Fly   186 VFEVIEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQE------NLENQKKLSGKLYLVDLAGSEK 244

  Fly   255 ADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGN 319
            ...|||:||.|.|..||||||:.||.||||||:  ..|.:      ||||||.||.:|:|:||||
  Fly   245 VSKTGAEGTVLDEAKNINKSLSALGNVISALAD--GNKTH------IPYRDSKLTRILQESLGGN 301

  Fly   320 SKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIR-----------ELKEEI 373
            ::|.::...|||..|..||.|||.:..|||.:.....|||:..|:..:           .||.::
  Fly   302 ARTTIVICCSPASFNESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKV 366

  Fly   374 QKLR-DLLK-AEGIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELNETWEE 436
            :||. :|.: ..|..|:.|:::....::::.|.:       .|:...|..|:|..:|
  Fly   367 EKLEIELARWRAGETVKAEEQINMEDLMEASTPN-------LEVEAAQTAAAEAALA-------- 416

  Fly   437 KLKRTEEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNL-SECLLYYIKEGLTR 500
                     .||.|: |.|..:|.                   :||...| :||...|     .:
  Fly   417 ---------AQRTAL-ANMSASVA-------------------VNEQARLATECERLY-----QQ 447

  Fly   501 LGTHEANVPQDIQLSGSHILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILG 565
            |...:..:.|..|.:..  |||....:.:             :..|.|:  |.|.|::
  Fly   448 LDDKDEEINQQSQYAEQ--LKEQVMEQEE-------------LIANARR--EYETLQS------- 488

  Fly   566 KNHVFRFTNPEQARELRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEMKKRLDN 630
                      |.||     |:.|||:..|                            |:|:.|..
  Fly   489 ----------EMAR-----IQQENESAKE----------------------------EVKEVLQA 510

  Fly   631 LEE---QYKREKLQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNP 692
            |||   .|.    |..|:.:.:.|.    ||||.::::::   .|::::.|.| ..|.:|:.::.
  Fly   511 LEELAVNYD----QKSQEIDNKNKD----IDALNEELQQK---QSVFNAASTE-LQQLKDMSSHQ 563

  Fly   693 MYESCWTAREAGLAAWAFRKWRYHQFTSLRDDLW--GNAIFLKEANAISVELKKKVQFQFTLLTD 755
                              :|......|:|..||.  |.||...|:   |::||...
  Fly   564 ------------------KKRITEMLTNLLRDLGEVGQAIAPGES---SIDLKMSA--------- 598

  Fly   756 TLYSPLPPELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNGATHHWSLEKLRYRLELMRQIYN 820
                     ||.|.|...:||.    .:::..::...|:.||                :.::..|
  Fly   599 ---------LAGTDASKVEEDF----TMARLFISKMKTEAKN----------------IAQRCSN 634

  Fly   821 VESPPSSMLFDTSGMEA-LSGWISPPSQHPGQQAQLLPLEPPV-ESERGRLTLANLIPS------ 877
            :|:..:......|..|. |..:....|||   :|::..|:..: |:|..:.||...|.|
  Fly   635 METQQADSNKKISEYEKDLGEYRLLISQH---EARMKSLQESMREAENKKRTLEEQIDSLREECA 696

  Fly   878 ---------------RQRLELMREMYHNEAEMSPTSPDYNVESLTGGDPFYDRFPWFRMVGRSFI 927
                           :||.|.:|.|:.::.:....:....|..|..
  Fly   697 KLKAAEHVSAVNAEEKQRAEELRSMFDSQMDELREAHTRQVSELRD------------------- 742

  Fly   928 YLSNLLYPVPLVHKVAIVNERGDVRGYLRIAVQPV-LDEESIDFNNGVKQSARLVFNEDDAKPKY 991
                     .:..|...::|..||...|.:|.|.: .|.|.:              .::||:...
  Fly   743 ---------EIAAKQHEMDEMKDVHQKLLLAHQQMTADYEKV--------------RQEDAEKSS 784

  Fly   992 R-----ALNEKDDVQRYIDNGGLDSKLEELEDVDSGRGIDSNSASE------CHENSEEPGEHLQ 1045
            .     ..||:.:..|....|..|:..:||:.:.:.|.:......:      .:|.|||.|..|.
  Fly   785 ELQNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKLFVQDLQQRIRKNVVNEESEEDGGSLA 849

  Fly  1046 VGKEFTFRVTVL-QATGIGAEY----ADIFCQFNFLHR-------HEEAFSTEPVKNSASGAPLG 1098
            ..::.:|....| |.|.:..:.    ||:.|:...|.:       ..:|..| .:|.:..||...
  Fly   850 QKQKISFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRCTMERVKALET-ALKEAKEGAMRD 913

  Fly  1099 FYHVQNITVPVTKSFIEYLKTQPIMFKIFGHYQTHPLHKDAKQDFVSRPPPRRMLPPSIPISQPV 1163
            ....|                          |:...:.:..:|..:.|..|:..      |::|:
  Fly   914 RKRYQ--------------------------YEVDRIKEAVRQKHLGRRGPQAQ------IAKPI 946

  Fly  1164 RSPK-----------FGPLPCAPTSTV 1179
            ||.:           .||.|.|..:.|
  Fly   947 RSGQGAIAIRGGGAVGGPSPLAQVNPV 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	144/362 (40%)
		Kinesin_assoc	355..498	CDD:465047	30/156 (19%)
		FHA_KIF1	474..574	CDD:438757	17/100 (17%)
		YhaN	<575..>666	CDD:443752	22/93 (24%)
		KIF1B	878..924	CDD:463574	7/45 (16%)
		DUF3694	1199..1347	CDD:463599
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	144/355 (41%)
		Smc	<341..>807	CDD:440809	125/697 (18%)
		Khc_CBD_cc	856..925	CDD:467880	15/95 (16%)