Protein Alignment unc-104 and Kif1a

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: XP_038940678.1
• Gene: Kif1a / 363288
• RGDID: 1304996
• Length: 1800
• Species: Rattus norvegicus
• Alignment Length: 1858
• Identity: 1002/1858 - (53%)
• Similarity: 1260/1858 - (67%)
• Gaps: 213/1858 - (11%)

  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSH-DHHDA 65
            :|||||||||||||||::|:|||||:|:|:||.|.|||.|..|.   |.|:|||||||| ...|.
  Rat     4 ASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETP---KSFSFDYSYWSHTSPEDI 65

  Fly    66 DFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLFTRI 130
            ::::|..||:|||||||||:|:||||||||||||||||||||||:||:.|:||||.:|:|||:||
  Rat    66 NYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDLFSRI 130

  Fly   131 QDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIHDL 195
            .||..|::.||||||||||||||||||||||||||||||||||||||||||||||||.|.||.||
  Rat   131 NDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDL 195

  Fly   196 IDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERADSTGA 260
            :|.|||||||||||||||||||||||.|.|||:|||..||:||||||||||||||||||||||||
  Rat   196 MDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERADSTGA 260

  Fly   261 KGTRLKEGANINKSLTTLGKVISALAEVAS---KKKNTKKADFIPYRDSALTWLLRENLGGNSKT 322
            |||||||||||||||||||||||||||:.|   |.|..||.||||||||.|||||||||||||:|
  Rat   261 KGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLGGNSRT 325

  Fly   323 AMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGI-- 385
            ||:||:|||||||||||||||||||||||.|.|::|||.|.|||||||:|:.:|||||.|:|:
  Rat   326 AMVAALSPADINYDETLSTLRYADRAKQIRCNAIINEDPNNKLIRELKDEVTRLRDLLYAQGLGD 390

  Fly   386 -----EVQEEDELTKSTVIKSPTKSRNRNGST----------------TEMAVDQLQASEKLIAE 429
                 .|....:||.:.|..||:.|.:...|.                :|.|:::|:.:||:|||
  Rat   391 ITDTNTVPGGPKLTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAE 455

  Fly   430 LNETWEEKLKRTEEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYI 494
            |||||||||:|||.||::|||:.||||||::|||.|:||||||||||||||||||.:||||||||
  Rat   456 LNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYI 520

  Fly   495 KEGLTRLGTHEANVPQDIQLSGSHILKEHCTFENKN-----STVTLLPHKDAIIYVNGRKLVEPE 554
            |:|:||:|..:|...|||.|||..|.:|||.|.:.:     :.|||.|.:.|..||||:|:.||.
  Rat   521 KDGVTRVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVNGKKVTEPS 585

  Fly   555 VLKTGSRVILGKNHVFRFTNPEQARELRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQGID 619
            :|::|:|:|:||:|||||.:|||||:.|::        ....:|..:.|||.|||.|||||||||
  Rat   586 ILRSGNRIIMGKSHVFRFNHPEQARQERER--------TPCAETPAEPVDWAFAQRELLEKQGID 642

  Fly   620 LKAEMKKRLDNLEEQYKREKLQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQ 684
            :|.||::||..||:||:||:.:|....|:||..||::::|||||::         |.|.||...:
  Rat   643 MKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMD---------SRYYPEVNEE 698

  Fly   685 EEDVYTNPMYESCWTAREAGLAAWAFRKWRYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQFQ 749
            ||:    |..|..||.||..||.||||||:::|||||||.|||||||||||||||||||||||||
  Rat   699 EEE----PEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKKVQFQ 759

  Fly   750 FTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNGATHHWSLEKLRYRLEL 814
            |.||||||||||||:|....|...:|..    |..:|:|||||.|.||||||:|:|||||.||:|
  Rat   760 FVLLTDTLYSPLPPDLLPPEAAKDRETR----PFPRTIVAVEVQDQKNGATHYWTLEKLRQRLDL 820

  Fly   815 MRQIYN-VESPPSSMLFDTS-------------------GMEALSGWISPPSQHPGQQAQLLPLE 859
            ||::|: ....|||::.|..                   |...:||..|.|..:.....::..|.
  Rat   821 MREMYDRAAEVPSSVVEDCDNVVTGGDPFYDRFPWFRLVGSSVISGCNSYPLLNTCMSERMAALT 885

  Fly   860 P-------------PVESERGRLTLANLIPSRQRLELMREMYHNEAEM-SPTSPDYNVESLTGGD 910
            |             |.|.:.        :...:..|...|....|.:: ....|::.:  ..|.|
  Rat   886 PSPTFSSPDSDTTEPAEEQS--------VGEEEEEEEEEEEEEEEEDLEDDVFPEHTL--CDGQD 940

  Fly   911 PFYDRFPWFRMVGRSFIYLSNLLYPVPLVHKVAIVNERGDVRGYLRIAVQPV-LDEESIDFNNGV 974
            |||||.|.|.:|||:|:|||||||||||||:||||:|:|:|:|:||:|||.: .|||:.|:.:||
  Rat   941 PFYDRPPLFSLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYGSGV 1005

  Fly   975 KQS--ARLVFNEDDAKPKYRALNEKDDVQRYIDNGGLDSKLEELEDVD-SGRGIDSN-SASECHE 1035
            :||  |::.| :|....|::  :|...|.....:|   :..|||..|: .|:|.|:. ||.|.:.
  Rat  1006 RQSGTAKISF-DDQHFEKFQ--SESCPVVGMSRSG---TSQEELRIVEGQGQGADAGPSADEVNN 1064

  Fly  1036 N--SEEPGE--------------------HLQVGKEFTFRVTVLQATGIGAEYADIFCQFNFLHR 1078
            |  |..|.|                    ||::|..||||||||||:.|.||||||||||||:||
  Rat  1065 NTCSAVPPEGLLDSPEKAALDGPLDTALDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHR 1129

  Fly  1079 HEEAFSTEPVKNSASGAPLGFYHVQNITVPVTKSFIEYLKTQPIMFKIFGHYQTHPLHKDAKQDF 1143
            |:|||||||:||:..|.||||||||||.|.||||||||:|:|||:|::|||||.||.....|...
  Rat  1130 HDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVL 1194

  Fly  1144 VSRPPPRRMLPPSIPISQPVRSPKF------GPLPCAPTSTVLAKHDVLVWFEICELAPNGEYVP 1202
            ....|.||..|..:|:|:||.:.|.      .|.||.      .|:|:||:||||||..||:|:|
  Rat  1195 SPLRPSRRHFPRVMPLSKPVPATKLSTMTRPSPGPCH------CKYDLLVYFEICELEANGDYIP 1253

  Fly  1203 SVVEHSDDLPCRGLFLLHQGIQRRIRITIVHEPTTEVKWKDINELVVGRIRNTPESSDEQDEDAC 1267
            :||:|...:||.|.|||||||||||.:|::||..:.::||::.|||||||||||| :||...|..
  Rat  1254 AVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELVVGRIRNTPE-TDEALIDPN 1317

  Fly  1268 VLSLGLFPGEALEVPGDD---------RSFYRFEAAWDSSLHNSALLNRVSQGGETIYITLSAYL 1323
            :|||.:.....:....||         |:||:||||||||:|||.|||||:...|.||:|||||:
  Rat  1318 ILSLNILSSGYVHPAQDDRQFLDSDIPRTFYQFEAAWDSSMHNSLLLNRVTPYREKIYMTLSAYI 1382

  Fly  1324 ELENCARPAIITKDLSMVIYGRDAR-TGPRSLKHLF-SGQYRNPEANRLTGVYELALRRASEAGS 1386
            |:|||.:||:||||..||.|.|||: ...||:::|| ||..|..|.||:||||||:|...::|||
  Rat  1383 EMENCTQPAVITKDFCMVFYSRDAKLPASRSIRNLFGSGSLRATEGNRVTGVYELSLCHVADAGS 1447

  Fly  1387 PGVQRRQRRVLDTSSTYVRGEENLHGWRPRGDSLIFDHQWELEKLTRLEEVGRMRHLLLLRERLG 1451
            ||:|||:|||||||..||||||||.|||||.||||.|||||||||:.|:||.:.||.|||||:|.
  Rat  1448 PGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELEKLSLLQEVEKTRHYLLLREKLE 1512

  Fly  1452 MDTNPNP---TTKTEKDVCNLAARAATSPVHMVIPQSPQTPVKDPQQIIPEREYNQREQDLMLKC 1513
            ....|.|   :..:.:|..:.::..|:||:.   .:...:|::.|         |:|:::|.:||
  Rat  1513 TTQRPVPEVLSPASSEDSESRSSSGASSPLS---AEGQPSPLEVP---------NERQRELAVKC 1565

  Fly  1514 LKLV----QGRYTKSEANDTQTQS-----------DVSPSDEGCADMTVSCISSNSMENNKFVIR 1563
            |:|:    ...||.|....:.::|           |.|.|..|.|.:|.|....:.:|.......
  Rat  1566 LRLLMHTFNREYTHSHVCISASESKLSEMSVTLMRDPSMSPLGAATLTPSSTCPSLIEGRYGATD 1630

  Fly  1564 RRLCSPDRADAPNGWEAPAPATQPAL-----------------PLRLYVPELEEIRVSPVVARKG 1611
            .|  :|.....|   .:|.|...|.|                 |.||.||:::||||||:|::||
  Rat  1631 VR--TPQPCSRP---ASPEPELLPELDSKKTPSPVRATETEKEPQRLLVPDIQEIRVSPIVSKKG 1690

  Fly  1612 LLNVLEHGGSGWKKRWVIVRRPYVFIYRSEKDPVERAVLNLATAHVECSEDQAAMVKIPNTFSVV 1676
            .|:.||...:||.||:|:|||||.::|.|:||.|||.||||:||.||.||||.||:|.||||:|.
  Rat  1691 YLHFLEPHTAGWAKRFVVVRRPYAYMYNSDKDTVERFVLNLSTAQVEYSEDQQAMLKTPNTFAVC 1755

  Fly  1677 TKHRGYLLQTLGDKEVHDWLYAINPLLAGQIKSRLARR 1714
            |:|||.|||...||::||||||.||||||.|:|:|:||
  Rat  1756 TEHRGILLQANSDKDMHDWLYAFNPLLAGTIRSKLSRR 1793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	286/359 (80%)
		Kinesin_assoc	355..498	CDD:465047	90/165 (55%)
		FHA_KIF1	474..574	CDD:438757	59/104 (57%)
		YhaN	<575..>666	CDD:443752	44/90 (49%)
		KIF1B	878..924	CDD:463574	14/46 (30%)
		DUF3694	1199..1347	CDD:463599	85/156 (54%)
		PH_KIFIA_KIFIB	1602..1704	CDD:269939	65/101 (64%)
Kif1a	XP_038940678.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	286/359 (80%)
		Kinesin_assoc	358..524	CDD:465047	90/165 (55%)
		FHA_KIF1A	500..614	CDD:438778	64/113 (57%)
		ERM_helical	633..>686	CDD:466641	29/52 (56%)
		KIF1B	814..861	CDD:463574	12/46 (26%)
		DUF3694	1250..1406	CDD:463599	85/156 (54%)
		PH_KIFIA_KIFIB	1681..1783	CDD:269939	65/101 (64%)