Protein Alignment unc-104 and klp-20

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: NP_497178.1
• Gene: klp-20 / 3565057
• WormBaseID: WBGene00002230
• Length: 646
• Species: Caenorhabditis elegans
• Alignment Length: 691
• Identity: 214/691 - (30%)
• Similarity: 326/691 - (47%)
• Gaps: 142/691 - (20%)

  Fly     4 VKVAVRVRPFNSREIARESK----CIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSHDHHD 64
            |||.||.||.::.|..:..|    |..|.........:.:.||.|      |.|          |
 Worm     7 VKVVVRCRPISTTEKLQGHKIAVTCNDEEKAVNIKSLSQEDPPRT------FYF----------D 55

  Fly    65 ADFS---TQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEE-QQEGIIPMICKD 125
            |.||   .|..||......::::...|||..||||||||.||::||.|..|. :..||||.....
 Worm    56 AVFSPNTDQMTVYNVAARPIVENVLKGYNGTIFAYGQTGTGKTFTMAGDLEPVEMRGIIPNSFAH 120

  Fly   126 LFTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQ 190
            :|..|...: .|..:.|.|||:|||.|.:||||:..:.|||.::|.|.:|.||.:||...|.:..
 Worm   121 IFDHIAKCQ-HDTTFLVRVSYLEIYNEEIRDLLSKDHNGNLEIKERPDVGVYVRNLSNPTVENAS 184

  Fly   191 DIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERA 255
            .:..|::.|:|.|.|.||.||..||||||:||:.....|:.|:|.      .|:.|||||||||.
 Worm   185 KMQALMEFGSKNRKVGATAMNLESSRSHAMFTVTIESCRNGLVTQ------GKLQLVDLAGSERQ 243

  Fly   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGNS 320
            ..|||:|.||||.|.||.||:|||.|||:|.:        .|:..||||:|.||.||:::|||||
 Worm   244 SKTGAQGERLKEAAKINLSLSTLGNVISSLVD--------GKSTHIPYRNSKLTRLLQDSLGGNS 300

  Fly   321 KTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGI 385
            ||.|||.:.||..||||||||||||:|||.|...|.:|||.....:|:.:.||:.||.:|..|
 Worm   301 KTVMIANVGPATYNYDETLSTLRYANRAKNIQNVAKINEDPKDAQLRKFQLEIEALRKILDEE-- 363

  Fly   386 EVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTE-EIRVQRE 449
                           :|....|:                      .|.||.|::..| |:..:|:
 Worm   364 ---------------NPGDDENQ----------------------EEAWEAKMQEREVEMEKKRK 391

  Fly   450 AVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQL 514
            .:...:..||.::          :|..||   ::...:|..|...:....:|.:....:.:.:.:
 Worm   392 ILEERVNSAVNDE----------ETHRLV---KEMMENEAELKKARSEHEKLRSKLEKIEKKLIV 443

  Fly   515 SGSHILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQAR 579
            .|.::|::             :..:..::.||.::|.:.:.                     |..
 Worm   444 GGENLLEK-------------VEEQAKLLEVNNKELEQSKF---------------------QEA 474

  Fly   580 ELRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEMKKRLDNLEEQYKREKLQADQ 644
            .||.::|.....:.|:|:..:...:..|.:.:.::|...:|| :.:..|.:|||.::|:
 Worm   475 HLRTQLEERTAVKVEIEERYSSLQEEAFVKSKKIKKVSNELK-DARAELKDLEEDHQRQ------ 532

  Fly   645 QFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQE 685
                    .||.:|.:::..:|..:.:::...|.|.: |.|
 Worm   533 --------VEAMLDDIRQLRKELLLNIAIIDEYIPVE-HVE 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	159/361 (44%)
		Kinesin_assoc	355..498	CDD:465047	27/143 (19%)
		FHA_KIF1	474..574	CDD:438757	11/99 (11%)
		YhaN	<575..>666	CDD:443752	18/90 (20%)
		KIF1B	878..924	CDD:463574
		DUF3694	1199..1347	CDD:463599
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
klp-20	NP_497178.1	Motor_domain	5..331	CDD:473979	157/354 (44%)
		Smc	<325..>556	CDD:440809	57/331 (17%)