DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-104 and neb

DIOPT Version :9

Sequence 1:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster
Sequence 2:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster

Alignment Length:	1041	Identity:	312/1041 - (29%)
Similarity:	488/1041 - (46%)	Gaps:	244/1041 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSVKVAVRVRPFNSREIAR-ESKCIIEMAGATTAITNPKVPPNTSDSVKR-----FNFDYSYWSH 60
            |::.|||||||.|:.|..| :...::::.|.:..:|   |...:|.....     |::|..|:|.
  Fly   119 SNMIVAVRVRPLNALECTRGQVTNVVQVHGNSNELT---VQAGSSADASAGVTHFFSYDQVYYSC 180

  Fly    61 DHHDADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQ-----------EEQ 114
            |....:|:.|:.|::.....::..:|:|||.|:|||||||:||||:|||.:           ...
  Fly   181 DPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHD 245

  Fly   115 QEGIIPMICKDLFTRIQDTET-DDLKYSVEVSYMEIYCERVRDLLN------------------P 160
            :.||||..|.:||.||:..:: ..|:..|||||.|||.|::.|||:                  .
  Fly   246 EAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQ 310

  Fly   161 KNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFF 225
            :.:..|:|||||:.||||.|||..:|..|..:.:.:..||..|..|:|.||:.|||||::|.|..
  Fly   311 QQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVL 375

  Fly   226 TQRRHDLMTNLTTE------------------KVSKISLVDLAGSERADSTGAKGTRLKEGANIN 272
            .      :|:|:::                  :.|||||||||||||...:|:.|.|::||.:||
  Fly   376 N------LTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSIN 434

  Fly   273 KSLTTLGKVISALAEVASKKK-------NTKKADFIPYRDSALTWLLRENLGGNSKTAMIAAISP 330
            |||.||||||:|||:  |:|.       :...:.|:|||:|.|||||||||||||||.|:|.|||
  Fly   435 KSLLTLGKVIAALAD--SRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISP 497

  Fly   331 ADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGIEVQEEDELTK 395
            |.|:.||||:|||||.:|:.||.:..|||..:.|:||:|:.|:.:|:.|..    |.:.:..|:.
  Fly   498 ASIHADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRN----EYERQRRLSG 558

  Fly   396 STVIKSPTK---SRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQREAVFAEMGV 457
            ::....|.|   ..:.:.:..|....||...|:.::...::|.||||..|:   ||:   :|:.|
  Fly   559 NSNNPVPRKIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAED---QRK---SELRV 617

  Fly   458 AVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVP-------QDIQLS 515
             :|..|:.:.:.:.:|...||||..||.||..|.|.:.:||.|:|  ...:|       .||.|.
  Fly   618 -LKRRGLALELTAEQKQACLVNLTADPILSGTLFYLLPQGLVRIG--RGRLPGGSSSSQPDIVLD 679

  Fly   516 GSHILKEHCTFEN-KNSTVTLLP-HKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQA 578
            |..:..:||:.|: :...:.::| .:|...||||..|.:...|..|.|:::|.:|.||.:||..:
  Fly   680 GPLVALQHCSIEHERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCS 744

  Fly   579 RELRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEMKKRLDNLEEQYKREKLQAD 643
            :  |.|.:              ..||:..|..|:|:||...|::|::........:.::|:.|..
  Fly   745 Q--RGKAD--------------HPVDFQLAHQEILQKQEQQLRSELEAEKRAALTKIEQERAQHA 793

  Fly   644 QQFEE-----QRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNPMYESCWTAREA 703
            :.|||     :.:.::.:.::...:.|.|::.::....::|   .:.||..:.|..:|
  Fly   794 RDFEERLQCLELEQFKYKCNSEMLETERQALALAQQQEHTP---LRHEDAVSTPAQKS------- 848

  Fly   704 GLAAWAFRKWRYHQFTSLRD-----------DLWGNAIFLKEANAISVELKKKVQFQFTLLTDTL 757
                           |.|.|           .|....:.:|||.....:|
  Fly   849 ---------------TILEDIQRIMLNPSEESLHKTQLMVKEATQRCRQL--------------- 883

  Fly   758 YSPLPPELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNGATHHWSLEKLRYRLELMR------ 816
              .||.|...|..|    ||||   :.:|::.  :.|.:.|....|...:|...|:|:|
  Fly   884 --DLPLEFRQTQTP----DEFG---LLRTVIL--ILDKQRGLKAEWPTARLGVWLDLVRDNAEQQ 937

  Fly   817 ---------QIYNVESPP-----SSMLFDTSG-----------------------MEALSGWISP 844
                     |...|:..|     :..|.||..                       :.|.|...:.
  Fly   938 EKLNATTIFQSVEVDWEPLDADLNETLSDTHNSSRIALNLSAMKDVLLNKPLKRLLNASSSKSNT 1002

  Fly   845 PSQ----HPGQQ-----AQLLPLEPP--VESERGRLTLANLIPSRQRLELM-----REMYHNEAE 893
            |.|    .||.|     .:||..:|.  .||:....||.     :|.|::|     |...|.||.
  Fly  1003 PRQTSTPSPGSQLVHFTKRLLTYDPEEIPESQSSFTTLV-----QQELQIMQRSAQRLRRHCEAA 1062

  Fly   894 M 894
            :
  Fly  1063 L 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	168/416 (40%)
		KISc	3..358	CDD:214526	167/415 (40%)
		Kinesin_assoc	355..498	CDD:292801	41/145 (28%)
		FHA	475..574	CDD:238017	36/107 (34%)
		KIF1B	878..923	CDD:289208	7/22 (32%)
		DUF3694	1246..1347	CDD:289256
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
		PH	1607..1700	CDD:278594
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	168/416 (40%)
		KISc	120..525	CDD:214526	167/415 (40%)
		Kinesin_assoc	524..657	CDD:292801	41/143 (29%)
		FHA	634..740	CDD:238017	36/107 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437952
Domainoid	1	1.000	252	1.000	Domainoid score	I517
eggNOG	1	0.900	-	-		E2759_KOG0245
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D6426at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850