Protein Alignment unc-104 and Klp31E

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: NP_609398.2
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Alignment Length: 1197
• Identity: 303/1197 - (25%)
• Similarity: 496/1197 - (41%)
• Gaps: 324/1197 - (27%)

  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMAGATTAIT--NPKVPPNTSDSVKRFNFDYSYWSHDHHD 64
            |||:||||:||.||||       :|:|....|.:|  .|::   ...|.|.|.|||.:.::
  Fly    12 SSVRVAVRIRPQNSRE-------LIDMCRICTTVTLGEPQI---FLGSDKAFTFDYVFDTN---- 62

  Fly    65 ADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTM-MGRQEEQ------QEGIIPMI 122
               |.|..:|.|..|:::..:..|||..:.||||||:||:||| .|...|.      |.||||..
  Fly    63 ---SNQCDIYSDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQLGIIPRA 124

  Fly   123 CKDLFTRIQDTETDDL----------KYSVEVSYMEIYCERVRDLLNPKNK-GNLRVREH----- 171
            .:.:|:.|:..|....          ::|:.|.|:|:|.|.:.|||:|.|| .|.::.|.
  Fly   125 VRHIFSGIEQLEGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSNFKIHEDASGQI 189

  Fly   172 PLLGPYVEDLSKLAVTDYQDIHD---LIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRR---- 229
            .:.|..::.:       ||. ||   .:.:|..|||.|:|.||:.||||||:||||..::|
  Fly   190 TISGASIKPI-------YQP-HDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTP 246

  Fly   230 ------HDLMTNLTTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEV 288
                  :||.| ||    ||...||||||||...|.|.|.|.:||.:||..|..||..||||.:
  Fly   247 SDNVPDNDLET-LT----SKFHFVDLAGSERLKRTQATGERAREGISINCGLLALGNCISALGD- 305

  Fly   289 ASKKKNTKKADFIPYRDSALTWLLRENLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVC 353
                 .:|:|..:|||||.||.||:::|||||:|.|||.:||:|.::.|||:||:||:||:.|..
  Fly   306 -----KSKRALHVPYRDSKLTRLLQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYANRARNIKN 365

  Fly   354 KAVVNEDANAKLIRELKEEIQKLR-DLLKAEGIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAV 417
            |..:|:|.:::.|.:|:.||..|: :||:.:..::..:.|                 |:||
  Fly   366 KVKINQDQSSRTISQLRREIAALQLELLEYKQGKLIVDCE-----------------GNTT---- 409

  Fly   418 DQLQASEKLIAELNETW-EEKLKRTEEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNL- 480
                        :::|: |.||..:|..|:|:.         :|....|:...:.:......||
  Fly   410 ------------ISDTFNENKLLLSEIKRLQQR---------LKSLQSTIATLTQRNADLKTNLD 453

  Fly   481 --------NEDPNLSECLLYY---IKEGLTRLGTHEANVPQDIQLSGSHILKEHCTFENKNSTVT 534
                    |.|..:::.:..|   |:|..|:|...|.:..|         ::...|...:|:.
  Fly   454 LNKWTSDDNSDVEIAKVVGQYMLEIEELQTKLIESEEHRKQ---------MEIKATTSPRNAK-- 507

  Fly   535 LLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQARELRDKIETEN--EAENEVEK 597
              |..|:.|....:|.:|.|.....||.:.|                   |:.:|  ..|.||..
  Fly   508 --PVYDSDIITKAKKDLERERELLMSRSLPG-------------------IQNQNVSSEETEVAS 551

  Fly   598 TDTQQVDWNFAQCELLEKQGIDLKAEMK-KRLDNLEEQYKREKLQADQQFEEQRKTYEARIDAL- 660
            :|::      |:..:.:.:.||...||: |.::.||        ..:.::|:.|..||.::..|
  Fly   552 SDSE------AEEVVKDLEAIDNDIEMRTKLIEQLE--------LTNSRYEQMRTHYEEKLSVLY 602

  Fly   661 ----QKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNPMYESCWTAREAGLAAWAFRKWRYHQFTSL 721
                ..|.|...:..:|.:|.|.......:.|.|:  |||..:                |..|.:
  Fly   603 CKIENTQKERDDVLANMTTSVSTPSKDSLKKVKTD--YESKIS----------------HMQTEI 649

  Fly   722 RDDLWGNAIFLKEANAISVELKKKVQFQFTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKT 786
            |          |..||....::.|.|.:                      .|:
  Fly   650 R----------KLQNAQREHIRSKQQLK----------------------SHE------------ 670

  Fly   787 LVAVEVTDTKNGATHHWSLEKLRY-RLELMRQIYNVESPPSSMLFDTSGMEALSGWISPPSQHPG 850
               |.:...:|      .|.:|:: :::||:::        |...:....|        .|:...
  Fly   671 ---VRIGTLRN------ELNELKFAKVKLMKKM--------SQQSNRHKQE--------ESRKSK 710

  Fly   851 QQAQLLPLEPPVESERGR---LTLANLIPSRQR---------LELMREMYHNEAEMSPTSPDYNV 903
            :.||||.     |..|.:   |||...:.::::         :.|.:.......:.:|......:
  Fly   711 EIAQLLK-----EQRRQKNAVLTLEAKVSAKEQILKRKTEEVIALRKSQRGKSGQRAPAHLTSKI 770

  Fly   904 ESLTGGDPFYDRFPWFRMVGRSFIYLSNLLYPVPLVHK--VAIVNERGDVRGYLRIAVQ-PVLDE 965
            .:|.|......|..|..:. |:.::.:.....:..:.|  ..::.||.|:...|.|... ...|.
  Fly   771 ATLDGFSTRSARHRWENLY-RNILHAARNRQLITQLEKELERLILEREDLSRELNIMENGQTADR 834

  Fly   966 ESIDFNNGVKQSARLVFNEDDAKPKYRALNE----KDDVQRYIDNGGLDSKLEELEDVDSGRGI- 1025
            ::.:||........:.:.:::.:...:|:.|    ||.||.:::.  :.|.|:|:..|...:.|
  Fly   835 QTDEFNEVDNLKTNISYIQENIEHVQQAIMEFEDTKDTVQSHVNK--IQSLLDEVSTVAEAKFIL 897

  Fly  1026 ----DSNSASECHENSEEPGEHLQ--------VGKEFTFRVTVLQ---ATGIGAEYADIFCQFNF 1075
                |:.....|:....|  .|||        |.:|...:..:||   :.......||||...|
  Fly   898 QKFSDTAIVMSCNLAIAE--SHLQEKESLLKEVKQESGIQQQILQHFLSQNSNVHIADIFDSLN- 959

  Fly  1076 LHRHEEAFSTEP------VKNSASGAP 1096
            |.....|.|..|      :.|:....|
  Fly   960 LKGSNIASSVNPGSQKSLISNATYDIP 986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	155/393 (39%)
		Kinesin_assoc	355..498	CDD:465047	29/156 (19%)
		FHA_KIF1	474..574	CDD:438757	22/111 (20%)
		YhaN	<575..>666	CDD:443752	20/98 (20%)
		KIF1B	878..924	CDD:463574	6/54 (11%)
		DUF3694	1199..1347	CDD:463599
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
Klp31E	NP_609398.2	KISc_KIF4	12..364	CDD:276823	153/387 (40%)
		Mplasa_alph_rch	<372..>748	CDD:275316	99/555 (18%)
		SMC_prok_B	622..>899	CDD:274008	61/371 (16%)
		Rcc_KIF21	798..870	CDD:410202	11/71 (15%)