DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-104 and nod

DIOPT Version :9

Sequence 1:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster
Sequence 2:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster

Alignment Length:	855	Identity:	199/855 - (23%)
Similarity:	321/855 - (37%)	Gaps:	242/855 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSHDHHDA 65
            :|:|::|||..|:. :.:.|....:::.             |..||. |....|.:.:..||...
  Fly     6 LSAVRIAVREAPYR-QFLGRREPSVVQF-------------PPWSDG-KSLIVDQNEFHFDHAFP 55

  Fly    66 DFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTM----MGRQEEQQEGIIPMICKDL 126
            ...:|..:|:.:...::....:|:.....||||||.||||:|    .|....:..||:|....|:
  Fly    56 ATISQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILPEHLGILPRALGDI 120

  Fly   127 FTRI---QDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTD 188
            |.|:   |:...|.::  |..|::|||.|:..|||.       .....|::....:..:.|.:..
  Fly   121 FERVTARQENNKDAIQ--VYASFIEIYNEKPFDLLG-------STPHMPMVAARCQRCTCLPLHS 176

  Fly   189 YQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSE 253
            ..|:|.:::.|.:.|.|..||||..||||||:.||....:.|.          |::::|||||||
  Fly   177 QADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHVKSKTHH----------SRMNIVDLAGSE 231

  Fly   254 RADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGG 318
            ....||.:|...:||.|||..|.::.||:.::|...:         .||||||.||.:|:.:|..
  Fly   232 GVRRTGHEGVARQEGVNINLGLLSINKVVMSMAAGHT---------VIPYRDSVLTTVLQASLTA 287

  Fly   319 NSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAE 383
            .|....:|.|||...:..|||||||:.               .:||.:|....::.:.:..|.|.
  Fly   288 QSYLTFLACISPHQCDLSETLSTLRFG---------------TSAKKLRLNPMQVARQKQSLAAR 337

  Fly   384 GIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQR 448
            ...|..: .|..||.|||...:.|    :..:...:...::.|.|.|:.|
  Fly   338 TTHVFRQ-ALCTSTAIKSNAANHN----SIVVPKSKYSTTKPLSAVLHRT--------------- 382

  Fly   449 EAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQ 513
               .:|:|:..|         :.|:...|:.|.|                           ..::
  Fly   383 ---RSELGMTPK---------AKKRARELLELEE---------------------------TTLE 408

  Fly   514 LSGSHILKEHCTFENKNSTVTLLP-HKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQ 577
            ||..||         ::|:::||. |.|:   ...|.|:.|   .||.             .|.|
  Fly   409 LSSIHI---------QDSSLSLLGFHSDS---DKDRHLMPP---PTGQ-------------EPRQ 445

  Fly   578 ARELRDKI-----ETENEAENEVEKTDTQQVDWNFAQCELLEK--QGIDLKAEMKKRLDNLEEQY 635
            |......:     |||.:..::|:::..........:|:|...  ..|.|:|...:|
  Fly   446 ASSQNSTLMGIVEETEPKESSKVQQSMVAPTVPTTVRCQLFNTTISPISLRASSSQR-------- 502

  Fly   636 KREKLQADQQFEEQRKTYEA--RIDALQKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNPMYESCW 698
               :|...|..||   |..|  :...|::.|...|...|......|:..:...
  Fly   503 ---ELSGIQPMEE---TVVASPQQPCLRRSVRLASSMRSQNYGAIPKVMNLRR------------ 549

  Fly   699 TAREAGLAAWAFRKWRYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQFQFTLLTDTLYSPLPP 763
            :.|.||:        |.|                    |.||.:|.:        ||.:     |
  Fly   550 STRLAGI--------REH--------------------ATSVVVKNE--------TDAI-----P 573

  Fly   764 ELASTVAPVHQEDEFGAPP---VSKTLVAVEVTDTKN----------GATHHWSLEKLRYRLELM 815
            .|.|||......:...||.   .:.|...:::.:..|          |....:||...|.||...
  Fly   574 HLRSTVQKKRTRNVKPAPKAWMANNTKCFLDLLNNGNVKQLQEIPGIGPKSAFSLALHRSRLGCF 638

  Fly   816 RQIYNVESPP 825
            ..::.|:|.|
  Fly   639 ENLFQVKSLP 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	108/362 (30%)
		KISc	3..358	CDD:214526	107/361 (30%)
		Kinesin_assoc	355..498	CDD:292801	24/142 (17%)
		FHA	475..574	CDD:238017	17/99 (17%)
		KIF1B	878..923	CDD:289208
		DUF3694	1246..1347	CDD:289256
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
		PH	1607..1700	CDD:278594
nod	NP_001285129.1	KISc	8..325	CDD:214526	110/374 (29%)
		KISc	8..318	CDD:276812	107/367 (29%)
		ComEA	540..648	CDD:224472	29/160 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437900
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030