Protein Alignment unc-104 and Kif21b

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: XP_063128266.1
• Gene: Kif21b / 289397
• RGDID: 1306206
• Length: 1635
• Species: Rattus norvegicus
• Alignment Length: 1425
• Identity: 329/1425 - (23%)
• Similarity: 560/1425 - (39%)
• Gaps: 382/1425 - (26%)

  Fly     4 VKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSHDHHDADFS 68
            ||||||:||    ::::|.   ||.....|::| |..|.......|.|.:|:.:      |.| :
  Rat     9 VKVAVRIRP----QLSKEK---IEGCHICTSVT-PGEPQVLLGKDKAFTYDFVF------DLD-T 58

  Fly    69 TQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGR-----QEEQQEGIIPMICKDLF- 127
            .|..:|.....::::..|:|||..:.|||||||||:|| ||.     ..|:::||||.....||
  Rat    59 WQEQIYSTCVSKLIEGCFEGYNATVLAYGQTGAGKTYT-MGTGFDTVTSEEEQGIIPRAIAHLFR 122

  Fly   128 ------TRIQDTETDDLKYSVEVSYMEIYCERVRDLLNP-------KNKGNLRVREHPLLGPYVE 179
                  .|.|:......::.|...::|:|.|.:.||.:.       ..:.|:::.|....|.|..
  Rat   123 GIDERKRRAQEQGVTGPEFKVSAQFLELYNEEILDLFDSTRDPDARHRRSNIKIHEDANGGIYTT 187

  Fly   180 DLSKLAVTDYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKV--- 241
            .::...:...:::...:.:|..:||.|:|.||..||||||:|||...|.|.....:|..|.|
  Rat   188 GVTSRLINSQEELIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRVCAQPDLVNETVTGL 252

  Fly   242 ---------------SKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASK 291
                           :|...||||||||...|||.|.|.|||.:||..|..||.|||||.:
  Rat   253 PDGTAPTGTEYETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGD---- 313

  Fly   292 KKNTKKADFIPYRDSALTWLLRENLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAV 356
              .:||...:|||||.||.||:::|||||:|.|||.:||:|.::.|||:||:||:||:.|..|.|
  Rat   314 --QSKKVVHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVV 376

  Fly   357 VNEDANAKLIRELKEEIQKLRDLLKAEGIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQ 421
            ||:|..::.|..|:.||.:|                                     :|.:.:.:
  Rat   377 VNQDKTSQQISALRAEIARL-------------------------------------QMELMEYK 404

  Fly   422 ASEKLIAELN-ETWEEKLKRTEEIRVQREAVFAEMGVAVKEDG-ITVGVFSPKKTPHLVN----- 479
            |.:::|.|.. |.:.:              :|.|..:..||:| :.:.|.:.::....:|
  Rat   405 AGKRVIGEDGAEGYSD--------------LFRENAMLQKENGALRLRVKAMQEAIDAINNRVTQ 455

  Fly   480 -LNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLSGSHILKEHCTFENKNSTVTLLPHKDAII 543
             ::::.||   ||....:|...:|....|..::|:...:.:|:.....|:...:::....::.
  Rat   456 LMSQEANL---LLAKAGDGNEAIGALIQNYIREIEELRTKLLESEAMNESLRRSLSRASARNP-- 515

  Fly   544 YVNGRKLVEP--------------EVLKTGSRVI--LGKNHV--FRFTNPE-QARELRDKIETEN 589
            |..|.....|              ||::...:.:  |.|..|  .|.::|| :|.:.|.|::.||
  Rat   516 YSLGASPAGPAFGGSPASSMEDASEVIRRAKQDLERLKKKEVRQRRKSSPEKEAFKKRAKLQQEN 580

  Fly   590 EAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEMKKRLDNLEEQYKREKLQAD----------- 643
            ..|.:..:.:.::.:.:.:.||  |::..|..:|......:.:.:.|....|||
  Rat   581 SEETDENEAEEEEEERDESGCE--EEEDEDSGSEESLVDSDSDPEEKEVNFQADLADLTCEIEIK 643

  Fly   644 QQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEED-VYTNPMYESCWTAREAGLAA 707
            |:..::.:..:.|:..|:.|.||:.:.:    .....|...|.| |..|.....|:|..:|....
  Rat   644 QKLIDELENSQRRLQTLKHQYEEKLILL----QNKIRDTQLERDRVLQNLSTMECYTEEKANKIK 704

  Fly   708 WAFRKWRYHQFTSLRDDLW-------GNAIFLKEANAISVELKKKVQFQFTLLTDTLYSPLPPEL 765
            ..:.|    :...:..||.       .:|..||..:....||||                |..|:
  Rat   705 ADYEK----RLREMNRDLQKLQAAQKEHARLLKNQSRYERELKK----------------LQTEV 749

  Fly   766 ASTVAPVHQEDEFGAPPVSKTLVAV-----------EVTDTKNGATHHWSLEKLRYRLELMRQIY 819
            |.               :.|..||:           .:.:||.      :.|..:.:.|..||.:
  Rat   750 AE---------------MKKAKVALMKQMREEQQRRRLVETKR------NREIAQLKKEQRRQEF 793

  Fly   820 NVESPPSS-------MLFDTSGMEALSGWISPPSQHPGQQAQLLPLEPP--------------VE 863
            .:.:..|.       :...|..:.||.....|.|:   :.|..:.|:||              .|
  Rat   794 QIRALESQKRQQEIVLRRKTQEVSALRRLAKPMSE---RVAGRVGLKPPNMDSGAEVSASTTSSE 855

  Fly   864 SERGRLTLANLIPSRQRLELMREMYHNEAEMSPTSPDYNVESLTGGDPFYDRFPWFRMVGRSFIY 928
            :|.|..::::::....|            :::....|:...::.|..|...:|. .:...:||..
  Rat   856 AESGARSVSSIVRQWNR------------KINHFLGDHPTATVNGARPARKKFQ-KKGASQSFSK 907

  Fly   929 LSNLLYP------VPLV-HKVAIVNERGDVRGYLRIAVQPVLDEESIDFNNGVKQSARLVFNEDD 986
            .:.|.:.      :.:| .::.|||...|:...::...:..|.:|::.     ::..||.....:
  Rat   908 AARLKWQSLERRIIDIVMQRMTIVNLEADMERLIKKREELFLLQEALR-----RKRERLQAESPE 967

  Fly   987 AKPKYRALNEKDDVQR----YIDNG---------GLDSKLEELEDVDSGRGIDSNSASECH---- 1034
            .:...:.|.|:.:|..    ||::.         .|:...|||:..|:...|.|.|.:|..
  Rat   968 EEKGLQELAEEIEVLAANIDYINDSITDCQATIMQLEETKEELDSTDTSVVISSCSLAEARLLLD 1032

  Fly  1035 ---ENSEEPGEHLQVG-KEFTFRV---TVLQATGIGAEYADIFCQ----------------FNFL 1076
               :.|.:.|  |||. ||...|:   .:.|....|:....:...                :|..
  Rat  1033 NFLKASIDKG--LQVAQKEAQIRLLEGRLRQTDMTGSSQNHLLLDALREKAEAHPELQALIYNVQ 1095

  Fly  1077 HRHEEAFSTEPV--------------KNSAS------------------------GAPLGFYHVQ 1103
            |.:..|.:.|.|              |.|.|                        |.||     .
  Rat  1096 HENGYASTDEEVSEFSEGSFSQSFTMKGSTSHDDFKFKGEPKLSAQMKAVSAECLGPPL-----D 1155

  Fly  1104 NITVPVTKSF--IEYLKTQPIMFKIFGHYQTHPLHKDAKQDFVSRPP-----PR--RMLPPSIPI 1159
            :.|..:|||.  :..:|...:.|.|     ..|.::|.....||.|.     ||  |....:.|:
  Rat  1156 SSTKNITKSLASLVEIKEDGVGFSI-----RDPYYRDKVSRTVSLPTRGSTFPRQSRGATDTSPL 1215

  Fly  1160 S--------QPVRSPKFGPLPCAPTS-TVLAKHDVLVWFEICELAPNGEYVPSVVEHSDD 1210
            :        ||:||...|..|  |:| ....::|..|:..:......|    |.::.|||
  Rat  1216 TRRKSYDRGQPIRSTDIGFTP--PSSPPTRPRNDRNVFSRLTSNQSQG----SALDKSDD 1269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	141/390 (36%)
		Kinesin_assoc	355..498	CDD:465047	25/150 (17%)
		FHA_KIF1	474..574	CDD:438757	20/123 (16%)
		YhaN	<575..>666	CDD:443752	21/102 (21%)
		KIF1B	878..924	CDD:463574	5/45 (11%)
		DUF3694	1199..1347	CDD:463599	4/12 (33%)
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
Kif21b	XP_063128266.1	None