Protein Alignment unc-104 and Kif28

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: NP_001257314.1
• Gene: Kif28 / 289309
• RGDID: 1559696
• Length: 1034
• Species: Rattus norvegicus
• Alignment Length: 1382
• Identity: 363/1382 - (26%)
• Similarity: 529/1382 - (38%)
• Gaps: 467/1382 - (33%)

  Fly     3 SVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSHDHHDAD- 66
            ||:||||||||:.||....|:|:|.|...:..|.:||    .::.||.|.||.:|||||....|
  Rat    16 SVRVAVRVRPFSQREKNSGSQCVISMHARSITIRDPK----DAELVKTFTFDLAYWSHDGFQKDE 76

  Fly    67 ------------FSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGII 119
                        |:.||.|:.|||..:|..::.|||..:.||||||:||||:|:|  ....:|||
  Rat    77 DGVLIPSDPTSKFAGQSDVFHDIGRGILDSAWQGYNATLLAYGQTGSGKSYSMIG--YGANKGII 139

  Fly   120 PMICKDLFTRIQDTETDDLKYSVEVSYMEIYCERVRDLLN-PKNKGNLRVREHPLLGPYVEDLSK 183
            |.:|::||..| :.:.:.|:..|..|.:|||.|::||||: .|..|.|||||...||.:||.|..
  Rat   140 PRVCEELFQAI-EKQKESLEAQVMFSMLEIYNEQIRDLLSRTKAPGGLRVREDQRLGFFVEGLKW 203

  Fly   184 LAVTDYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVD 248
            :...|...|..|:::|:|.|..|:||||.:|||||.:..|.|.|...|  |.||  |.|.|::||
  Rat   204 VPCEDSVQIEKLVEQGSKIRMTASTNMNASSSRSHMLIAIRFKQVFLD--TALT--KQSSINMVD 264

  Fly   249 LAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLR 313
            ||||||..|:|::|.||:||:.:|.|||.||.||||||::|.    .||...||||||.||.||:
  Rat   265 LAGSERQRSSGSEGDRLREGSRVNLSLTNLGNVISALADLAM----GKKVLHIPYRDSVLTKLLQ 325

  Fly   314 ENLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRD 378
            ..|||||:|.:|||:|||||.|:|||||||||:|||::..:||:|   ...|:|..:.|...
  Rat   326 SALGGNSRTTLIAALSPADICYEETLSTLRYAERAKKVRNRAVIN---TCPLVRASRAENAL--- 384

  Fly   379 LLKAEGIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTEE 443
            ||...|....|.                    |....|..||           .||....:..|:
  Rat   385 LLGFGGAGAAEH--------------------SACFWAEQQL-----------GTWGTWAQLLEQ 418

  Fly   444 IRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANV 508
            .|.:.|..:  |.:|.::..:       |..|||:|:||||.|:..|.::|..|...:|...:|.
  Rat   419 ARREWEQQY--MALAQEQQMV-------KILPHLLNVNEDPQLTGVLKFFIHNGSCEVGRAASNA 474

  Fly   509 PQDIQLSGSHILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFT 573
               |.|....|..:|.:|.|.:..||:.||....:.|||..:.....|:...|:|||.|..|.:.
  Rat   475 ---ICLQSLGISDKHASFTNMDGKVTVAPHITGKVIVNGVPVSSRTKLQHLDRIILGSNSAFLYI 536

  Fly   574 NPEQARELRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEMKKRLDNLEEQYKRE 638
            .          ..:|..||      |..:.|::|.|.|....:|:
  Rat   537 G----------FPSERGAE------DLGRFDYDFFQMERAAAEGV-------------------- 565

  Fly   639 KLQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNPMYESCWTAREA 703
                                           ::.|..:.||.|...:..:
  Rat   566 -------------------------------SVDMLGTASPGDDQADPSI--------------- 584

  Fly   704 GLAAWAFRKWRYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQFQFTLLTDTLYSPLPPELAST 768
             ||.       :..:..|..       .:.|||.:|.||||.::.:..:          ..|||:
  Rat   585 -LAV-------FQDYIKLMP-------LVVEANQMSEELKKGLKMELKV----------KNLASS 624

  Fly   769 VAPVHQEDEFGAPPVSKTLVAVEVTDTKNGATHH---WSLEKLRYRLELMRQIYN--VESPPSSM 828
                   |..|.....:.:|.|    ||.| ||.   ||..|...|..||.::|.  :||..|
  Rat   625 -------DSRGCDLQKEVMVKV----TKQG-THEVWIWSKAKFINRKFLMEELYQRFLESRDS-- 675

  Fly   829 LFDTSGMEALSGWISPPSQHPGQQAQLLPLEPPVESERGRLTLANLIPSRQRLELMREMYHNEAE 893
                               |..|:
  Rat   676 -------------------HVAQE----------------------------------------- 680

  Fly   894 MSPTSPDYNVESLTGGDPFYDRFPWFRMVGRSFIYLSNLLYPVPLVHKVAIVNERGDVRGYLRIA 958
                           .|||:|......: |.:.::|.:|.:.:.|..:|..:|..|.....|.|.
  Rat   681 ---------------DDPFWDPVEVLHL-GSAHVWLQSLAHRMMLEEQVEFLNCEGLEEAVLHIQ 729

  Fly   959 VQPVLDEESIDFNNGVKQSARLVFNEDDAKPKYRALNEKDDVQRYIDNGGLDSKLEELEDVDSGR 1023
            :.|                         ..|:..|..|:|.|            ::.||
  Rat   730 ITP-------------------------CSPEGWAHGEEDTV------------IDPLE------ 751

  Fly  1024 GIDSNSASECHENSEEPGEHLQVGKEFTFRVTVLQATGI-------------GAEYADIFCQFNF 1075
                                 .:||...|::.::|..|:             |.:..|:   .|.
  Rat   752 ---------------------LLGKRIDFQIHIVQCLGVKWLKEDATRGIQLGYKVYDL---PNT 792

  Fly  1076 LHRHEEAFSTEP-VKNSASGAPLGFYHVQNITVPVTKSFIEYLKTQPIMFKIFGHYQTHPLHKDA 1139
            |:......|..| |:.|...|.||          |::.|:.||.|..::..::| .|....|
  Rat   793 LYTKPVWQSVNPRVEESVHFAALG----------VSREFLNYLLTNALVVDLWG-LQEGCAH--- 843

  Fly  1140 KQDFVSRPPPRRMLPPSIPISQP-----------VRSPKFGPLPCAPTSTVLAKHDVLVWFE-IC 1192
                             :.:|||           |.:..|..:....::.|...:..|:..| ..
  Rat   844 -----------------LGVSQPDVLFTGEGYIMVDTKTFSSVKDITSNQVPELYQKLLKLEQET 891

  Fly  1193 EL------APNGE--YVPSVVEHSDDLPCRGLFLLHQGIQRRIRITIVHEPTTEVKWKDINELVV 1249
            ||      |..||  |:.:.:|::...|        ||.:|      .|:|
  Rat   892 ELLRDINRALRGENVYLKAALENAGSAP--------QGERR------YHKP-------------- 928

  Fly  1250 GRIRNTPESSDEQDEDACVLSLGLFPGEALEVPGDDRSFYRFEAAWDSSLHNSALLNRVSQGGET 1314
                :.||                  |..:...|:.:......|:.||.|   |...:|..||
  Rat   929 ----DNPE------------------GATVTAAGEAKQMCAQRASSDSQL---ARALKVFYGG-- 966

  Fly  1315 IYITLSAYLELENCARP 1331
            :.:.....|.|..|..|
  Rat   967 MSVARGQLLRLRQCRPP 983

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	179/368 (49%)
		Kinesin_assoc	355..498	CDD:465047	33/142 (23%)
		FHA_KIF1	474..574	CDD:438757	34/99 (34%)
		YhaN	<575..>666	CDD:443752	9/90 (10%)
		KIF1B	878..924	CDD:463574	4/45 (9%)
		DUF3694	1199..1347	CDD:463599	25/135 (19%)
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
Kif28	NP_001257314.1	Motor_domain	15..370	CDD:473979	179/368 (49%)
		FHA_KIF28P	441..538	CDD:438761	34/109 (31%)
		KIF1B	655..693	CDD:463574	13/114 (11%)