DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-104 and klp8

DIOPT Version :9

Sequence 1:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster
Sequence 2:	NP_594675.1	Gene:	klp8 / 2542849	PomBaseID:	SPAC144.14	Length:	511	Species:	Schizosaccharomyces pombe

Alignment Length:	490	Identity:	143/490 - (29%)
Similarity:	231/490 - (47%)	Gaps:	92/490 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSVKVAVRVRPFNSREIARESKCI--IEMAGATTAITNPK------VPPNTSDSVKRFNFDYSYW 58
            ::|:|.|||||.:.||:::.::.:  ::....|..||.||      ...|..:..:.|.||..:.
pombe     4 ANVRVIVRVRPKSLRELSKSAEDLLSVDSHNKTVTITPPKHGLKHSRHKNRVNGPRTFAFDECFA 68

  Fly    59 SHDHHDADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMIC 123
            .......:.|.|..||:..|..:::...:|:|.|...|||.|.||:|:::|.:  .|.||||.|.
pombe    69 PSAPESKNLSGQEDVYESTGPLLVKSILEGFNSCFITYGQKGTGKTYSVVGLR--GQPGIIPHIS 131

  Fly   124 KDLFTRIQDTETDDLK-------YSVEVSYMEIYCERVRDLLNPKNKGN------LRVREHPLLG 175
            :.:|     .|.|.||       .:|.:|..||..|...|||.|....:      :.|::..|.|
pombe   132 ESIF-----EEIDKLKKKSPNTTITVSISLAEIIEETPYDLLQPNVNSSHTPGETVFVQKDSLTG 191

  Fly   176 PYVEDLSKLAVTDYQDIHDLIDEGNKARTVAATNMNETSS------RSHAVFTIFFTQRRHDLMT 234
            .::..||:..|...|:|...:       .:||.|:....|      :.|:||::...||..|..|
pombe   192 YHLHGLSEFEVGSAQEIDAFL-------RLAAKNIRTELSDISGVRKGHSVFSLVVQQRIIDPKT 249

  Fly   235 NLTTEKVSKISLVDLA----GSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNT 295
            ..:.:|.|::.::|||    ||:|.:|..:     .|.::.||||:.|.:||:||   .|||.:.
pombe   250 RHSLKKASRLQIIDLASFSKGSQRNESISS-----FESSSNNKSLSVLNRVIAAL---TSKKNDV 306

  Fly   296 KKADFIPYRDSALTWLLRENLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNED 360
                .|||:||.||.||::.||||.:|.|:..:||.|  :|:|.|.|||::.|::|  |.:.|
pombe   307 ----LIPYKDSVLTTLLQDALGGNCRTIMLTCVSPCD--FDDTFSALRYSEAARRI--KNISN-- 361

  Fly   361 ANAKLIRELKEEIQKLRDLLKAEGIEVQEEDELTK-STVIKSPTKSRNRNGSTTEMAVDQLQASE 424
            .|.|                  |......|.||.. .|.::|..:...|:...::..:
pombe   362 INCK------------------EAYSTNNEGELDDILTTLESDREQLRRHEEHSQKLL------- 401

  Fly   425 KLIAELNETWEEKLKRTEEIRVQREAVFAEMGVAV 459
            |.|.|:...:||::...|.   |..|:.|.:.:||
pombe   402 KFIEEIRNDYEERIHALES---QNSALKAHLRLAV 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	122/386 (32%)
		KISc	3..358	CDD:214526	122/385 (32%)
		Kinesin_assoc	355..498	CDD:292801	21/106 (20%)
		FHA	475..574	CDD:238017
		KIF1B	878..923	CDD:289208
		DUF3694	1246..1347	CDD:289256
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
		PH	1607..1700	CDD:278594
klp8	NP_594675.1	KISc	5..354	CDD:276812	119/376 (32%)
klp8	NP_594675.1	Kinesin	11..356	CDD:278646	117/372 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910