DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-104 and tea2

DIOPT Version :9

Sequence 1:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster
Sequence 2:	NP_596620.1	Gene:	tea2 / 2539857	PomBaseID:	SPBC1604.20c	Length:	628	Species:	Schizosaccharomyces pombe

Alignment Length:	549	Identity:	164/549 - (29%)
Similarity:	264/549 - (48%)	Gaps:	99/549 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSVKVAVRVRPFNSRE-IARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSHDHHDA 65
            |.:..::|:||....: :....|...:..|      ...:...||.|......:|.:      :.
pombe   131 SGIITSIRIRPIGKNQGVWSHGKLSNDPYG------REYIRQQTSTSSSTIQQEYLF------NN 183

  Fly    66 DFSTQSM---VYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLF 127
            .|..:|.   :||...:.::::.|.|||..:||||.||.||:|:|.|  .|.:.||||:...|||
pombe   184 VFGMESKNYDIYKRSVKSVVRNVFSGYNGIVFAYGMTGTGKTYSMQG--TENEPGIIPLAMNDLF 246

  Fly   128 TRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDI 192
            ..:::...|| .:.:.:||:|||.||:|||:...:: ..|:||:......|..|:::.||..:::
pombe   247 EMVENNSDDD-TFQIRISYLEIYNERIRDLIGNSDE-EPRIRENASGEVNVTPLTRVLVTSPEEV 309

  Fly   193 HDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLT--TEKVSKISLVDLAGSERA 255
            ..:|::.|..|..|||:.|..||||||:..:|.      :..|.|  |.::|.:|||||||||||
pombe   310 SQVIEQCNAIRKTAATDFNTYSSRSHAILQVFL------IRNNPTAHTSQISSLSLVDLAGSERA 368

  Fly   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGNS 320
               .|...|.||||.|||||.|||.|||.|: .|:....|..:..||||:|.||.||:::|.|.|
pombe   369 ---SAHHERRKEGAFINKSLLTLGTVISRLS-AAANPSLTSNSGHIPYRESKLTRLLQQSLSGQS 429

  Fly   321 KTAMIAAISPADINYDETLSTLRYADRAKQI-----VCKAVVNEDAN-AKLIRELK---EEIQKL 376
            :.:::|.||....:..||.:||::|.||:.:     ..:||.|..|. |.|...|:   :|::..
pombe   430 QISLLATISIESNHTMETTNTLKFASRAQNLPQDIRQAEAVTNVQAELASLHSALEKNAQEVEYY 494

  Fly   377 RDLLKAEGIEVQEED--------ELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKL-IAELNE 432
            ..|:|....:::|.|        |.::.|.|           |...:.:::|.:.... ||:|.:
pombe   495 ASLVKQLTSDLEERDTYIAMLEAERSQGTAI-----------SRARLRMEELLSDHNFEIADLRD 548

  Fly   433 TWEEKLKRTEEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEG 497
            ..::|           |.:...:..|.|:..|.....|..|.||.:               :|:.
pombe   549 ELQDK-----------EQIIYALRYAQKQRDIADFNQSLAKFPHKI---------------LKKN 587

  Fly   498 LTRLGTHEAN-----------VPQDIQLS 515
            :|| |:..::           :|.|.|.|
pombe   588 VTR-GSRSSSDQFSNETKTEILPDDQQQS 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	129/366 (35%)
		KISc	3..358	CDD:214526	128/365 (35%)
		Kinesin_assoc	355..498	CDD:292801	30/155 (19%)
		FHA	475..574	CDD:238017	10/52 (19%)
		KIF1B	878..923	CDD:289208
		DUF3694	1246..1347	CDD:289256
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
		PH	1607..1700	CDD:278594
tea2	NP_596620.1	Motor_domain	133..460	CDD:277568	126/352 (36%)
tea2	NP_596620.1	Kinesin	138..459	CDD:278646	126/346 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2883
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940