Protein Alignment unc-104 and unc-104

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: NP_001022041.2
• Gene: unc-104 / 174144
• WormBaseID: WBGene00006831
• Length: 1628
• Species: Caenorhabditis elegans
• Alignment Length: 1781
• Identity: 902/1781 - (50%)
• Similarity: 1180/1781 - (66%)
• Gaps: 196/1781 - (11%)

  Fly     1 MSSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKV-PPNTSDSVKRFNFDYSYWSHDHHD 64
            ||||||||||||||.|||:..|||::::.|.||.|....: ..|.|     ||||:||||...:|
 Worm     1 MSSVKVAVRVRPFNQREISNTSKCVLQVNGNTTTINGHSINKENFS-----FNFDHSYWSFARND 60

  Fly    65 ADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQE-GIIPMICKDLFT 128
            ..|.||..||:::|.|||:|:|:|||||||||||||:||||||||:..:..| ||||.:|.|||.
 Worm    61 PHFITQKQVYEELGVEMLEHAFEGYNVCIFAYGQTGSGKSYTMMGKANDPDEMGIIPRLCNDLFA 125

  Fly   129 RIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIH 193
            ||.:....|::|||||||||||||||:|||||.:.|||||||||||||||:||:|:||..|.||.
 Worm   126 RIDNNNDKDVQYSVEVSYMEIYCERVKDLLNPNSGGNLRVREHPLLGPYVDDLTKMAVCSYHDIC 190

  Fly   194 DLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERADST 258
            :|:|||||||||||||||.|||||||||||..||:||...:||.|||.||||||||||||||:||
 Worm   191 NLMDEGNKARTVAATNMNSTSSRSHAVFTIVLTQKRHCADSNLDTEKHSKISLVDLAGSERANST 255

  Fly   259 GAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGNSKTA 323
            ||:|.||||||||||||||||.|||.|||.::|||.:.|. .||||||.||||||||||||||||
 Worm   256 GAEGQRLKEGANINKSLTTLGLVISKLAEESTKKKKSNKG-VIPYRDSVLTWLLRENLGGNSKTA 319

  Fly   324 MIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGIEVQ 388
            |:||:||||||:||||||||||||||||||:||||||.||||||||.||:.|||.:||.:||:|.
 Worm   320 MLAALSPADINFDETLSTLRYADRAKQIVCQAVVNEDPNAKLIRELNEEVIKLRHILKDKGIDVT 384

  Fly   389 EEDELTKSTVIKSPTKSRNRNG----STTEMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQRE 449
            :..|          |..:::.|    :.....:::||.||||:||:.:|||:||..|||||.|||
 Worm   385 DVQE----------TPGKHKKGPKLPAHVHEQLEKLQESEKLMAEIGKTWEQKLIHTEEIRKQRE 439

  Fly   450 AVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQL 514
            ....:||:|..|||.|:|||||||.||||||||||.:||||:||:|||:|.:|..||....||.|
 Worm   440 EELRDMGLACAEDGTTLGVFSPKKLPHLVNLNEDPLMSECLIYYLKEGVTSVGRPEAEHRPDILL 504

  Fly   515 SGSHILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQAR 579
            ||..||:.||.|.|::..|||....:|..|:||:::..|.||.||||||||::||||:.:|::||
 Worm   505 SGEAILELHCEFINEDGNVTLTMKPNASCYINGKQVTTPTVLHTGSRVILGEHHVFRYNDPQEAR 569

  Fly   580 ELRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEMKKRLDNLEEQYKREKLQADQ 644
            :.|..:....|          |.:||.:||.|||:||||||||:|:|::..:|.||:|||::.:|
 Worm   570 QSRHNLAAIAE----------QPIDWKYAQQELLDKQGIDLKADMEKKMLEMESQYRREKVELEQ 624

  Fly   645 QFEEQRKTYEARIDALQKQVE---------------EQSMTMSMYSSYSPEDFHQEEDVYTNPMY 694
            :...|.:.||:.|:.|||||:               |:.:|.|:..  .||:..
 Worm   625 KMYHQTREYESMIENLQKQVDLAQSYISGGGSIWEGERMLTSSLLE--FPEELK----------- 676

  Fly   695 ESCWTAREAGLAAWAFRKWRYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQFQFTLLTDTLYS 759
               ||:.:..:...|..|||||||||:||||||||||:||||||||||||||||||.|||||:||
 Worm   677 ---WTSDQKRVVLKAAIKWRYHQFTSVRDDLWGNAIFVKEANAISVELKKKVQFQFALLTDTMYS 738

  Fly   760 PLPPELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNGATHHWSLEKLRYRLELMRQIYNVESP 824
            ||||:|      :...::....|..||:||::|.|.||||||:||:|||:.|||.||..||.|..
 Worm   739 PLPPDL------LPPGEDLTLRPYPKTVVAIQVQDLKNGATHYWSIEKLKQRLEDMRIFYNSELS 797

  Fly   825 PSSMLFDTSGMEALSGWISPPSQHPGQQAQLLPLEPPVESERGRLTLANLIPSRQRLELMREMYH 889
            .:....|........||::..:::.                      |.|||.|||||.||:||.
 Worm   798 VAGTPVDVPYPPVAEGWLAALNRNS----------------------ARLIPDRQRLEAMRDMYE 840

  Fly   890 NEAEMSPTSPDYNVESLTGGDPFYDRFPWFRMVGRSFIYLSNLLYPVPLVHKVAIVNERGDVRGY 954
            .:|||||...|..:::|.|.|||||||||||||||:|:||:|||:.|||:||||:|||:|:|:||
 Worm   841 TDAEMSPADGDPMMDALMGTDPFYDRFPWFRMVGRAFVYLNNLLHNVPLIHKVAVVNEKGEVKGY 905

  Fly   955 LRIAVQPVLDEESIDFNNGVKQSARLVFNEDDAKPKYRALNEKDDVQRYIDNGGLDSKLEELEDV 1019
            |::|::||..:|.|:...||:|:|:|.|.::|.                            |:..
 Worm   906 LKVAIEPVQKDEVINQKKGVRQTAKLHFRKEDF----------------------------LKSH 942

  Fly  1020 DSGRGIDSNSASECHENSEEPGEHLQVGKEFTFRVTVLQATGIGAEYADIFCQFNFLHRHEEAFS 1084
            .:|...||::.:.        .||:|...||.|||.||||..:...|:|:||||||||||:||||
 Worm   943 KNGETSDSDALAF--------PEHMQEEVEFCFRVVVLQAIDVADTYSDVFCQFNFLHRHDEAFS 999

  Fly  1085 TEPVKNSASGAPLGFYHVQNITVPVTKSFIEYLKTQPIMFKIFGHYQ--THPLHKDAKQDFVSRP 1147
            |||:|||.|  ||.|.|.||:.:.::|:|:.||...||:|::|||:|  :...:.:.:...:.|.
 Worm  1000 TEPMKNSKS--PLTFEHTQNLHIKMSKTFLHYLHHFPIIFEVFGHFQPKSEQFNFERQNSALGRR 1062

  Fly  1148 PPRRML--PPSIPISQPVRSPKFGPLPCAP----TSTVLAKHDVLVWFEICELAPNGEYVPSVVE 1206
            ...::.  .||:.||.||:|.|..    ||    .::|.:|||:||||||||||.||||||::|:
 Worm  1063 LSTKLTFQQPSLVISTPVKSKKAN----APIQNNNASVKSKHDLLVWFEICELANNGEYVPTIVD 1123

  Fly  1207 HSDDLPCRGLFLLHQGIQRRIRITIVHEPTTEVKWKDINELVVGRIRNTPESSDEQDEDACVLSL 1271
            |:..||..|:|||||||||||:|||.|| ..|:||||..||||||||..||.:...|.|  ||||
 Worm  1124 HAQGLPTHGIFLLHQGIQRRIKITICHE-KGELKWKDCQELVVGRIRAGPEWAGGDDVD--VLSL 1185

  Fly  1272 GLFPGEALEVPGDDRSFYRFEAAWDSSLHNSALLNRVSQGGETIYITLSAYLELENCARPAIITK 1336
            |||||..:|...|||:|::||||||||||||.||||||..|:.||:|||||:||:.||:||::||
 Worm  1186 GLFPGTFMEFSMDDRTFFQFEAAWDSSLHNSPLLNRVSNYGDQIYMTLSAYMELDGCAQPAVVTK 1250

  Fly  1337 DLSMVIYGRDAR--TGPRSLKHLFSGQYRNPEANRLTGVYELALRRASEAGSPGVQRRQRRVLDT 1399
            ||.::||.||::  ...|..:.|..|..::||.||:.|||:|.|:..|::|:   .|||||||||
 Worm  1251 DLCLLIYARDSKISAASRFCRSLVGGISKSPEMNRVPGVYQLCLKDGSDSGA---IRRQRRVLDT 1312

  Fly  1400 SSTYVRGEENLHGWRPRGDSLIFDHQWELEKLTRLEEVGRMRHLLLLRERLGMDTNPNPTTKTEK 1464
            ||.||||||||..||||||||||:|||||||||||::|.|:|..|.||:||....|     |.|
 Worm  1313 SSAYVRGEENLGQWRPRGDSLIFEHQWELEKLTRLQQVERVRLFLRLRDRLKGKKN-----KGE- 1371

  Fly  1465 DVCNLAARAATSPVHMVIPQSPQTPVKDPQQIIPER-EYNQREQDLMLKCLKLVQGRYTKSEAND 1528
                  ||...||.             ||...|||. :.:::::.::.|.|.|::.:...::...
 Worm  1372 ------ARTPVSPC-------------DPVCAIPESIKLDEKDKGIVGKVLGLIRRKIPMNKDPP 1417

  Fly  1529 TQTQSDVSPSDEGCADMTVSCISSNSM----ENNKFVIRRR-------LCSPDRADAPNGWEAPA 1582
            |..::. ..|||..::...|.:|..|:    .::..:.|::       ..:.|..|...|.:...
 Worm  1418 TGNKAQ-ELSDESGSNSITSPVSDKSLIKSSRSSDLLCRQKSKSDQNLASNDDIVDNLGGMKRSL 1481

  Fly  1583 PATQPALPLRLYVPELEEIRVSPVVARKGLLNVLEHGGSGWKKRWVIVRRPYVFIYRSEKDPVER 1647
            ..:: .|.|.:.|||:.|.||..||::||.:|.||....||.:|||||||||:.::|.::|.|.|
 Worm  1482 SGSR-ILQLNILVPEVLEERVGVVVSKKGYMNFLEEKTQGWTRRWVIVRRPYILLFRDDRDLVIR 1545

  Fly  1648 AVLNLATAHVECSEDQAAMVKIPNTFSVVTKHRGYLLQTLGDKEVHDWLYAINPLLAGQIKSRLA 1712
            .::|||.|.:|.||||.||||:||||||.|..||:|:|.:...|::|||||||||:|||:|..
 Worm  1546 GIINLANARIEHSEDQQAMVKVPNTFSVCTNQRGFLMQMMPGDEMYDWLYAINPLMAGQMKLH-- 1608

  Fly  1713 RRTLEPASQTASQIQATNAANANSAS 1738
                  .:|..:.:::..::::.:||
 Worm  1609 ------GNQNGTTLKSPTSSSSIAAS 1628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	253/357 (71%)
		Kinesin_assoc	355..498	CDD:465047	80/146 (55%)
		FHA_KIF1	474..574	CDD:438757	56/99 (57%)
		YhaN	<575..>666	CDD:443752	39/105 (37%)
		KIF1B	878..924	CDD:463574	30/45 (67%)
		DUF3694	1199..1347	CDD:463599	95/147 (65%)
		PH_KIFIA_KIFIB	1602..1704	CDD:269939	58/101 (57%)
unc-104	NP_001022041.2	KISc_KIF1A_KIF1B	2..354	CDD:276816	250/353 (71%)
		Kinesin_assoc	351..488	CDD:465047	75/140 (54%)
		FHA_KIF1	464..564	CDD:438757	57/99 (58%)
		Rcc_KIF21	595..652	CDD:425381	26/56 (46%)
		KIF1B	829..875	CDD:463574	4/45 (9%)
		DUF3694	1116..1260	CDD:463599	76/151 (50%)
		PH_KIFIA_KIFIB	1500..1602	CDD:269939	20/113 (18%)