DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-104 and Kif16b

DIOPT Version :9

Sequence 1:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster
Sequence 2:	XP_036014693.1	Gene:	Kif16b / 16558	MGIID:	1098240	Length:	1908	Species:	Mus musculus

Alignment Length:	1097	Identity:	383/1097 - (34%)
Similarity:	551/1097 - (50%)	Gaps:	193/1097 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ESKCIIEMAGATTAITNPKVPP-NTSDS----VKRFNFDYSYWSHDHHDADFSTQSMVYKDIGEE 80
            |:|.||:|..:.|.|||.|:|. .|.||    .|.|.:|:|::|.|....|:.:|.||:|.:|.:
Mouse    55 EAKFIIQMEKSKTTITNLKIPEGGTGDSGRERTKTFTYDFSFYSADTKSPDYVSQEMVFKTLGTD 119

  Fly    81 MLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLFTRIQD-TETDDLKYSVEV 144
            :::.:|:|||.|:|||||||:||||||||...:  .|:||.||:.||:||.: |..|:..:..||
Mouse   120 VVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGD--SGLIPRICEALFSRINETTRWDEASFRTEV 182

  Fly   145 SYMEIYCERVRDLLNPKNKG--NLRVREHPLLGPYVEDLSKLAVTDYQDIHDLIDEGNKARTVAA 207
            ||:|||.|||||||..|:..  ||||||||..|||||||||..|.:|.|:.:|:|.||..||.||
Mouse   183 SYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYVEDLSKHLVQNYSDVEELMDAGNINRTTAA 247

  Fly   208 TNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERADSTGAKGTRLKEGANIN 272
            |.||:.||||||:|||.|||.:.|  ..:..|.||||.|||||||||||:|||.|.|||||.|||
Mouse   248 TGMNDVSSRSHAIFTIKFTQAKFD--AEMPCETVSKIHLVDLAGSERADATGATGVRLKEGGNIN 310

  Fly   273 KSLTTLGKVISALAEVASKKKN---TKKADFIPYRDSALTWLLRENLGGNSKTAMIAAISPADIN 334
            |||.|||.||||||:::....|   .||..|:|||||.|||||:::|||||||.|||.|||||:|
Mouse   311 KSLVTLGNVISALADLSQDAANPLVKKKQVFVPYRDSVLTWLLKDSLGGNSKTIMIATISPADVN 375

  Fly   335 YDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGIEVQEEDELTKSTVI 399
            |.|||||||||:|||.|:.|..:|||||.||||||:.||.:|:.|| |:|.::         .::
Mouse   376 YGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIARLKTLL-AQGNQI---------ALL 430

  Fly   400 KSPTKSRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQREAVFAEMGVAVKEDGI 464
            .|||.....         ::|..:|..:.||.:.|..|...|:.|       ..|..:|::::||
Mouse   431 DSPTALSME---------EKLHQNEARVQELTKEWTNKWNETQNI-------LKEQTLALRKEGI 479

  Fly   465 TVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLSGSHILKEHCTFENK 529
              ||....:.|||:.:::|...:..:||::|||.|.:|..:|:..|||.|.|..:..|||.|||.
Mouse   480 --GVVLDSELPHLIGIDDDLLSTGIILYHLKEGQTYVGREDASTEQDIVLHGLDLESEHCVFENA 542

  Fly   530 NSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQARELRDKIETENEAENE 594
            ..||||:|.:.:...|||.::|:...|..|:.::||:.::|||.:|::|.:||:|.::...:...
Mouse   543 GGTVTLIPLRGSQCSVNGVQIVDATQLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFS 607

  Fly   595 VEKTDTQQVDWNFAQCELLEKQGIDLKAEMKKRLDNLEEQYKR--EKLQAD----QQFEEQRKTY 653
            :..||..:...|.:...|.......:|..:..||: .|.|.:.  |||::.    ::.||::|:.
Mouse   608 LSMTDLSKSCENLSAVMLYNPGLFPIKGPICLRLE-FERQQREELEKLESKRKLIEEMEEKQKSD 671

  Fly   654 EARIDALQKQVEE--------QSMTMSMYSSYSPEDFHQE---EDVYT-NPMYESCWTAREAGLA 706
            :|.::.:|::||.        |........|.....||.|   :|:.. ...:|......:.||.
Mouse   672 KAELERMQQEVETRRKETEIVQRQIRKQEESLKRRSFHIENKLKDLLAEKERFEEERLREQQGLE 736

  Fly   707 AWAFRKWRYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQ-FQFTLLTDTLYSPLPPELASTVA 770
            ..  |:........:|::|..    |:|.|  |.|..:||| ||              ||..
Mouse   737 QQ--RRQEEESLFRIREELRK----LQELN--SHEQAEKVQIFQ--------------ELDR--- 776

  Fly   771 PVHQEDEFGAPPVSKTLVAVEVTDTKNGATHHWSLEKLRYRLELMRQIYNVESPPSSMLFDTSGM 835
             :|||                    :|..:....|||.|...|...|:..|
Mouse   777 -LHQE--------------------QNAQSAKLRLEKRRLEEEEKEQVQRV-------------- 806

  Fly   836 EALSGWISPPSQHPGQQAQ----LLPLEPPVESERGRLTLANLIPSRQRLELMREMYHNEAEMSP 896
                       .|..:|.:    ..||..|.|::|.:       ..::.||.:||......||..
Mouse   807 -----------AHLEEQLRKRQDTAPLLCPGEAQRAQ-------EEKRELESIREALLQAKEMRA 853

  Fly   897 TSPDYNVESLTGGDPFYDRFPWFRMV-----GRSFIYLSNLLYPVPLVHKVAIVNERGDVRGYLR 956
            .......:.|.....::..|...::|     .:..:...:||.......|||:.:.:.|..|
Mouse   854 GGDHTCRDELERAQQYFLEFKRRQLVKLASLEKDLVQQKDLLSKEVQEEKVALEHVKCDAGG--- 915

  Fly   957 IAVQP---VLDEESI-----DFNNGVKQSARLVFNEDDAKPKYR-----ALNEKDDVQRYIDNG- 1007
               .|   ..|:.:|     |.:.......||...|...:...:     .|.||..|...:|:|
Mouse   916 ---DPSFLATDDGNILGGPPDLDKIKTAETRLQSREHQLQDLLQNHLPALLEEKQRVLDALDSGV 977

  Fly  1008 -GLDSKLEELEDVDSGRGIDSNSASECHENSEEPGEH---------LQVGKEFTFRV 1054
             |||:.|.::|             .|..|..|:..::         |:...|||..|
Mouse   978 LGLDTTLCQVE-------------KEVGEKEEQIAQYQANASQLQQLRATFEFTANV 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	201/347 (58%)
		KISc	3..358	CDD:214526	201/347 (58%)
		Kinesin_assoc	355..498	CDD:292801	43/142 (30%)
		FHA	475..574	CDD:238017	39/98 (40%)
		KIF1B	878..923	CDD:289208	9/49 (18%)
		DUF3694	1246..1347	CDD:289256
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
		PH	1607..1700	CDD:278594
Kif16b	XP_036014693.1	KISc_KIF1A_KIF1B	51..399	CDD:276816	201/347 (58%)
		Kinesin_assoc	398..510	CDD:406567	42/139 (30%)
		FHA	512..577	CDD:395400	25/64 (39%)
		SbcC	<644..1081	CDD:223496	96/475 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820