DRSC/TRiP Functional Genomics Resources

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Protein Alignment unc-104 and Kif13a

DIOPT Version :9

Sequence 1:NP_611155.3 Gene:unc-104 / 36876 FlyBaseID:FBgn0267002 Length:1739 Species:Drosophila melanogaster
Sequence 2:XP_036013758.1 Gene:Kif13a / 16553 MGIID:1098264 Length:1840 Species:Mus musculus


Alignment Length:1981 Identity:563/1981 - (28%)
Similarity:840/1981 - (42%) Gaps:621/1981 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKR----FNFDYSYWSHDH 62
            :.|||||||||.|.||:...:||::||.|..|.:..|  |.||....::    |.|||.:||.|.
Mouse     4 TKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPP--PSNTKQGERKPPKVFAFDYCFWSMDE 66

  Fly    63 -HDADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDL 126
             :...::.|.:|:|.:||.:|:.:|.|||.|||||||||:|||::|||..|  |.|:||.:|..|
Mouse    67 SNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAE--QLGLIPRLCCAL 129

  Fly   127 FTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPK-NKGNLRVREHPLLGPYVEDLSKLAVTDYQ 190
            |.||...:.:...:.|||||||||.|:|||||:|| ::.:|:||||.:|||||:.||:||||.::
Mouse   130 FQRIALEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGLSQLAVTSFE 194

  Fly   191 DIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERA 255
            ||..|:.||||:||||||||||.||||||||.|..||..:||.:..:.|||||:||||||||||.
Mouse   195 DIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERV 259

  Fly   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGNS 320
            ..|||.|.|||||:||||||||||.|||:||:.|:.|...|   |:|||||.|||||::||||||
Mouse   260 SKTGAAGERLKEGSNINKSLTTLGLVISSLADQAAGKGKNK---FVPYRDSVLTWLLKDNLGGNS 321

  Fly   321 KTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGI 385
            :|:|||.||||..||:|||||||||||||:||..||||||.|||:||||:||::|||        
Mouse   322 QTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAKVIRELREEVEKLR-------- 378

  Fly   386 EVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQREA 450
                 ::|:::..:|:|...            ::|:.|||||.||..||||||::||.|..:|:.
Mouse   379 -----EQLSQAEAMKAPELK------------EKLEESEKLIKELTVTWEEKLRKTEAIAQERQR 426

  Fly   451 VFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLS 515
            ....||::::..||.||    ....:|||||.||.|:|.|:||:|:. ||:|   |:..|||||.
Mouse   427 QLESMGISLETSGIKVG----DDKCYLVNLNADPALNELLVYYLKDH-TRVG---ADTSQDIQLF 483

  Fly   516 GSHILKEHCTFE-NKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQAR 579
            |..|..|||..: ..:..:||.|.::|...|||..:.....|..|.|::.|.||.||...|::.|
Mouse   484 GIGIQPEHCEIDIAADGDITLTPKENARSCVNGTLVCSTTQLWHGDRILWGNNHFFRINLPKRKR 548

  Fly   580 E--LRDKIETENEAENEVEKTD--TQQVDWN--FAQCELLEK----QG----IDLKA-------- 622
            .  |:|.....:.||::::...  :.:.|:|  |||.|::.|    .|    :.|.|        
Mouse   549 RDWLKDFERETSSAEHDLDAASEASSEPDYNYEFAQMEVIMKTLNSNGGFPIVSLSAWWSSPWWS 613

  Fly   623 -----------------------EMKKRLDNLEEQYKREKLQADQQFEEQRKTYEARIDALQKQV 664
                                   .::..:..||:||..||..|   .||||..||..::.|::|:
Mouse   614 YLKILFPLLWFQTKLVHQHWERDPVQNVVQVLEKQYLEEKRTA---LEEQRLMYERELEQLRQQL 675

  Fly   665 EEQSMTMSMYSSYSPEDFHQEEDVYTNPMYESCWTAREAGLAAWA------FRKWRYHQFTSLRD 723
                         |||  .|.....::.:..|..||::. :..||      ||:    ....||:
Mouse   676 -------------SPE--RQPPSSASDRLAYSSQTAQQK-VTQWAEERDELFRQ----SLAKLRE 720

  Fly   724 DLWGNAIFLKEANAISVELKKKVQFQFTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKTLV 788
            .|......::|||.::.|:.|...:|.||       .:|   |:.::...:.....:.|      
Mouse   721 QLVKANTLVREANFLAEEMSKLTDYQVTL-------QIP---AANLSANRKRGAIVSEP------ 769

  Fly   789 AVEVTDTKNGATHHWSLEKLRYRLELMRQIYNVESPPSSMLFDTSGMEALSGWISPPSQHPGQQA 853
            |::.. .|...|..|::|||..:|..||.:|                   ..|            
Mouse   770 AIQAR-RKGKGTQVWTIEKLENKLIDMRDLY-------------------QEW------------ 802

  Fly   854 QLLPLEPPVESERGRLTLANLIPSRQRLELMREMYHNEAEMSPTSPDYNVESLTGGDPFYDRFPW 918
                              ...:|..:||...|                       |||||:....
Mouse   803 ------------------KENVPEAKRLYGKR-----------------------GDPFYEAQEN 826

  Fly   919 FRMVGRSFIYLSNLLYPVPLVHKVAIVNERGDVRGYLRIAVQPV---LDEESIDFNNGVKQSARL 980
            ..::|.:.::|..|...|.|.:.|.|::::|:|.|.|.:.|..:   :.|.              
Mouse   827 HNLIGVANVFLECLFCDVKLQYAVPIISQQGEVAGRLHVEVTRITGTIPER-------------- 877

  Fly   981 VFNEDDAKPKYRALNEKDDVQRYIDNGGLDSKLEELEDVDSGRGIDSNSASECHENSEEPGEHLQ 1045
             ..|||:...                   .|:...||.|||.                  ||.:.
Mouse   878 -MAEDDSSEN-------------------SSESGSLEVVDSS------------------GEVIH 904

  Fly  1046 VGKEFTFRVTVLQATGIGAEYAD-IFCQFNFLHRHEEAFSTEPVKNSASGAP--------LGFYH 1101
            ..|:.|.||.:.:|||:....:: :|||:.|..:.|...:. ||.:....:|        :.|.|
Mouse   905 RVKKLTCRVIIKEATGLPISLSNFVFCQYTFWDQCESTVAA-PVVDPDVPSPQSKDAQYTVTFSH 968

  Fly  1102 VQNITVPVTKSFIEYLKTQPIMFKIFGH---------YQTHPLHKDAKQDFVSRPPPRRMLPPSI 1157
            .::..|.||:.|:|::....:..:::||         ::...||                     
Mouse   969 CKDYVVTVTEEFLEFISDGALAIEVWGHRCAGNGSPIWEVDSLH--------------------- 1012

  Fly  1158 PISQPVRSPKFGPLPCAPTSTVLAKHD--------VLVWFEICELAPNGEYVPSVVEHSDDLPCR 1214
                            |.|.|:   ||        :.||..|.||...|:|....:..:.|:...
Mouse  1013 ----------------AKTRTL---HDRWNEVTRRIEVWISILELNELGDYAAVELHQAKDVNTG 1058

  Fly  1215 GLFLLHQGIQRRIRIT---IVHEPTTEV------------------------------------- 1239
            |:|.|.||..||:::|   :.|..|..:                                     
Mouse  1059 GVFQLRQGHSRRVQVTVKPVQHSGTLPLMVEAILSVSIGCVTARSTKLQRGLDSYQRDEEDGGDM 1123

  Fly  1240 -------------KWKD--------INELVVGRIRNTPE-SSDEQDEDACVLS--LGLF------ 1274
                         :|.|        ::| .:.::.|..| :.|:.:.:|.::.  :||.      
Mouse  1124 DSYQEEDLNCVRERWSDALIKRREYLDE-QIKKVSNKKEKTEDDMEREARLVEQWVGLTEERNAV 1187

  Fly  1275 -------------------PGEALEVP-------GDDRS-------------------------F 1288
                               ||....:|       .||.|                         |
Mouse  1188 LVPAPGSGIPGAPADWVPPPGMETHIPVLFLDLNADDLSANEQLVGPHASGVNSILPKEHGSQFF 1252

  Fly  1289 Y-----------RFEAAWDSSLHNSALLNRVSQGGETIYITLSAYLELEN-CARPAIITKDLSMV 1341
            |           ...|:||||:|:|..||||:...|.||:.:...::|.: .|...::.|.::..
Mouse  1253 YLPIIKHSDDEVSATASWDSSVHDSLHLNRVTPQNERIYLIVKTTVQLSHPAAMELVLRKRIAAN 1317

  Fly  1342 IYGRDARTGPRSLKHLFSGQYRNPEANRLTGV-------YELA--LRRASEAGSPGVQRRQRRVL 1397
            ||.:.:.|  :|||...|          |..:       ||:.  :.:|:|      :...|..|
Mouse  1318 IYNKQSFT--QSLKRRIS----------LINICYSCGVTYEIVSNIPKATE------EIEDRETL 1364

  Fly  1398 DTSSTYVRGEENLHGWRPRGDSLIFDHQWELEKLTR-------LEEVGRMRHLLLLRERLGMDTN 1455
            ...:.....|..|.|            :..:||.||       :..:.|:|..:.::|.|     
Mouse  1365 ALLAARSENEGTLDG------------ETYIEKYTRGVLQVENILSLERLRQAVTVKEAL----- 1412

  Fly  1456 PNPTTKTEKDVCNLAARAATSPVHMVIPQSPQTPVKD------PQQIIPEREYNQREQDLMLKCL 1514
               :||..    ::....:|..||.|....|.....|      |:..:...:|:...||  :.|.
Mouse  1413 ---STKAR----HIRRSLSTPNVHNVSSSRPDLSGFDEDDKGWPENQLDVSDYSSSYQD--VACY 1468

  Fly  1515 KLVQGRYTKSEANDTQTQSDVSPSDEGCADMTVSCISSNSMENNKFVIRRRLCSPDRADAPNGWE 1579
                         .|..:.....|.|||.......::               .||.:|.:|.   
Mouse  1469 -------------GTLPRDSPRRSKEGCPSENPHALT---------------VSPFKAFSPQ--- 1502

  Fly  1580 APAPATQPALPL------RLYV---PELEEIRVSPVVAR----------KGLLNVLEHGGSGWKK 1625
             |....:|.:|:      ||.:   |.|.:..:.|..|.          .|....:||.....||
Mouse  1503 -PPKFFKPLMPVKEEHKKRLALEARPLLSQESMPPSQAHNPGCIVTPGSNGSSMPVEHSSKPEKK 1566

  Fly  1626 --------------RWVIVRRPYVFIYRSEKDPVERA---VLNLATAHVECSEDQA--------- 1664
                          |.:::.:|||        |||.|   |.|.:..:.|.|..:|         
Mouse  1567 IDSEEEENELEALSRKLMLTQPYV--------PVEFADFSVYNASLENREWSSSKADLTDSRALE 1623

  Fly  1665 -AMVKIPNTFSVVTKHRGYLLQTLGDKEVHD 1694
             |:.:.|.|.|:.:   ||...:..:..:.|
Mouse  1624 KAVSRSPTTSSLTS---GYFSHSASNATLSD 1651

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-104NP_611155.3 KISc_KIF1A_KIF1B 2..358 CDD:276816 213/361 (59%)
KISc 3..358 CDD:214526 213/360 (59%)
Kinesin_assoc 355..498 CDD:292801 58/142 (41%)
FHA 475..574 CDD:238017 42/99 (42%)
KIF1B 878..923 CDD:289208 8/44 (18%)
DUF3694 1246..1347 CDD:289256 34/172 (20%)
PH_KIFIA_KIFIB 1602..1704 CDD:269939 27/130 (21%)
PH 1607..1700 CDD:278594 26/125 (21%)
Kif13aXP_036013758.1 KISc_KIF1A_KIF1B 5..359 CDD:276816 213/360 (59%)
Kinesin_assoc 356..468 CDD:406567 57/140 (41%)
FHA 446..543 CDD:238017 42/100 (42%)
Smc <646..811 CDD:224117 52/253 (21%)
KIF1B 788..832 CDD:403579 15/115 (13%)
DUF3694 <1255..1319 CDD:403614 17/63 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D76316at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100247
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2883
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.850

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