Protein Alignment unc-104 and LOC1277078

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: XP_061498142.1
• Gene: LOC1277078 / 1277078
• VectorBaseID: AGAMI1_012463
• Length: 2263
• Species: Anopheles gambiae
• Alignment Length: 1871
• Identity: 407/1871 - (21%)
• Similarity: 692/1871 - (36%)
• Gaps: 515/1871 - (27%)

  Fly     3 SVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSV----KRFNFDYSYWSHDHH 63
            :|||:::|||...||  ||:|.:.:.          ::..|...::    ..|.||:.:
Mosquito     4 NVKVSIKVRPLIKRE--RENKLVSQW----------RIRDNIIATIDGNGDPFVFDHIF------ 50

  Fly    64 DADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLFT 128
            |....|:.: :..:...::..:.:|.|..|||||||.:||:|||:|  .:::.|::|:..:::|.
Mosquito    51 DETVPTRQL-FDTVCRPVILSALNGINGTIFAYGQTSSGKTYTMIG--NDREPGVVPLTAREIFE 112

  Fly   129 RIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTD-YQDI 192
            :|:  ...:.::.:.|.::|||.|::.||||..|. ||::.|:......|.  ||..:|: .:.|
Mosquito   113 QIK--RIKERQFLIRVGFIEIYNEKIHDLLNTANT-NLKIVENQCGDVSVN--SKECITNCAEQI 172

  Fly   193 HDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQR----RHDLMTNLTTE--KVSKISLVDLAG 251
            ...:|:|||||.:..|||||.|||||.:|.|....|    .:.:...:..|  ::..::||||||
Mosquito   173 IQHVDDGNKARKIGETNMNERSSRSHTIFRITIESRVIGPANGVDGGMDNEAVQIGILNLVDLAG 237

  Fly   252 SERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENL 316
            |||||.|||.|:|.|||..|||||.:|..||..|:|.:.|:       ||.||||.||.:|:.:|
Mosquito   238 SERADQTGATGSRFKEGVCINKSLLSLSCVIQKLSENSDKQ-------FINYRDSKLTRILQASL 295

  Fly   317 GGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNED-ANAKLIRELKEEIQKLRDLL 380
            |||:.|:||..|:||.:  |||..||.:|.|||.|..|..|||. .:|.:::.|:.||::|:..|
Mosquito   296 GGNAVTSMICNITPAVV--DETYYTLSFAMRAKNIRNKPKVNEILTDAAMMKRLEREIKRLQSEL 358

  Fly   381 KAE--------GIEVQEEDELTKSTVIKS-------PTKSRNR---------------------- 408
            ::|        .:|:|....|..:..|.|       ...:|.|
Mosquito   359 RSEQNKNSKIKTMELQNAITLRTNQFINSNQAQQSLADNARRRTWCPSTTEIPRLAPGHRPTPDL 423

  Fly   409 -------------------------NGSTTEMAVDQLQASEKLIA-------------------- 428
                                     ||:|.::|:..:.|.|..:|
Mosquito   424 MGEGGRTLMGPPPAVTNGGQYLVTMNGATPQIAIRSMSADEDYVATRSGDIRASDGFAATLALIG 488

  Fly   429 --ELNETWEEKLKRTEEIRVQREAVFAEMGVA----------VKEDGITVG-------------V 468
              |.|..:.|.|.. :::..:|....:..|:.          |..:.|:.|             :
Mosquito   489 EDEPNIQYRELLDH-QDLLARRVRSTSPNGLLNPFSSYGDEFVPGEQISFGSASVSPLSTMEREL 552

  Fly   469 FSPKK-----------TP--------------HLVNLNEDPNLSECL-LYYIKEGLTRLGTHEAN 507
            .:||.           :|              .|:.|.|...|...: ..::|:.|.:.....:.
Mosquito   553 HTPKSLRRTRRSSTGDSPPQFNFEQRCRELEQELLELQEFTKLENSVETQHLKKELDKRTGELSE 617

  Fly   508 VPQDIQLSGSHI--LKEHCT---FENKNSTVTL-LPHKDAIIYVNGRKLV--EPEVLK---TGSR 561
            :..|::.....:  |:|.|.   .|.|....|: ....|..:.|..|:..  |.|:.:   ||..
Mosquito   618 LKHDLEKKEQRLEQLEERCAQLEVELKGQMATVSKAENDLALAVKERQAAVREAELHRNQHTGIE 682

  Fly   562 VILGKNHVFRFTNPEQARELRDK--IETENEAENEVEKT---DTQQVDWNFAQCELLEKQGIDLK 621
                    |.:....|..|.|:|  ||:..||.|....:   |:.::|....:.:.||.|..:..
Mosquito   683 --------FEYERYRQRSEAREKELIESLQEARNNGATSNGGDSFKLDQKREEMKRLEMQNYEFT 739

  Fly   622 AEMKKRLDNLEEQYKREKLQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYS--SYSPEDFHQ 684
            .::::....| ||.|...|:..::.|..::........|.....:.::..|:..  ..||:...|
Mosquito   740 LQLEECNKQL-EQLKSSNLEQHRKLEIVKQAVLQHYQTLSGDFPQSALVNSLRKLLLLSPDGGEQ 803

  Fly   685 EEDVYTNPMYESCWTAREAGLAAWAFRKWRYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQFQ 749
            |....:|...::  |..::.|                  |..|||..| :.||..:..:|.:|..
Mosquito   804 EHTAQSNGFNDT--TMGQSVL------------------DGNGNATML-DGNATLMGEEKTIQEL 847

  Fly   750 FTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNGATH------HWSLEKL 808
            ..::         .:|..|:..:.||..          ...|.:|.:.|...      ..|:|:|
Mosquito   848 VKIV---------EQLEETIRALEQEKR----------ALQEASDVQLGELKSKLDGGQTSIERL 893

  Fly   809 RYRLELMRQIYNVESPPSSMLFDTSGMEALSGWISPPSQHPGQQAQLLPLEPPVESERGRLTLAN 873
            ...:...|:.:..:         |:..:.||      :|...|......|....| |..:..|||
Mosquito   894 EKEIAQWREKFAAQ---------TTEYDELS------TQLMDQMQDNEDLRKQFE-EAKQTALAN 942

  Fly   874 LIPSRQRLELMREM-----------YHNEA---------------EMSPTSPDYNVESLTGGDPF 912
            ....::|.||.|||           ...||               :.|..|....||::......
Mosquito   943 EKDVQRREELEREMGPLRESLEKANAEREALQRVCDSLREEVSALKASIESHASQVETIVAEKEQ 1007

  Fly   913 YDRFPWFRMVGRSFIYL---------SNLLYPVPLVH-----KVAIVNERGDVRGYLRIAVQPVL 963
            ..       |.|..:.:         ...:..:..|.     :||.|||..|......:.::..:
Mosquito  1008 LS-------VERDEVKIRLEEAITKQKETMKELETVQAAKQAEVATVNEEIDRLKQEIVKLETSI 1065

  Fly   964 DEESID----FNNGVKQSARLVFNEDDAKPKYRALNEK--DDVQRYIDNGGLDSKLEELEDVDSG 1022
            .|:|::    .....:.||:||..:.:.:....|.::|  :|:||          |::|:|...|
Mosquito  1066 GEQSVEKELLATENSRLSAQLVQLQKEQQLAGAASDQKAREDLQR----------LQQLKDEADG 1120

  Fly  1023 RGI----------DSNSASECHEN-------SEEPGEHLQVGKEFTFRVTVLQATGIGAEYADIF 1070
            |.:          :...|:|..:|       :|:.|...::| |...|:..|||:
Mosquito  1121 RVVQLEVELEVFKNKLDAAESEQNERFQQWEAEKQGLVKEIG-ELQLRMEELQAS---------- 1174

  Fly  1071 CQFNFLHRHEEAFSTEPVKNSASGAPLGFYHVQ---------NITVPVTKSFIEYLKTQPIMFKI 1126
                 ||:..|.      |||.:    ....:|         .:.|...|...|..:...:..|:
Mosquito  1175 -----LHQLREE------KNSQT----NLVQIQTEKESTLQEQLAVLRQKQASEEARIHELQQKV 1224

  Fly  1127 FGHYQ---THPLHKDAKQ--DFVSRPPPRRMLPPSIPISQPVRSPKFGPLPCA--------PTST 1178
            . .|:   .....::|||  .|.|          |:..:|.       .|.||        ....
Mosquito  1225 C-DYEGEIAALTEREAKQGESFES----------SLKQAQE-------ELDCARKALAQLTEEKD 1271

  Fly  1179 VLAKHDVLVWFEICELAPN-GEYVPSVVEHSDDLPCRGLFL------------LHQGIQRRIRIT 1230
            .:|..:..|..|:.:.|.. .|....:.|...:|.|....|            .|:..::.|...
Mosquito  1272 AIAAEEAKVREELLKAAQTVAELQKRIEEVEQELECSRSELSAIAGKQKEEQQSHEEARKEIEKQ 1336

  Fly  1231 IVHEPTTEVKWKDINELVVGRIRNTPESSDEQDEDACVLSLGLFPGEALEVPGDDRSFYRFEAAW 1295
            :....|...|.|:.|..:|.:     :..|.:|:..||        :||....|.......|...
Mosquito  1337 LEMANTALAKIKEDNSKLVKQ-----QHGDREDQAQCV--------QALTKCKDTLEQRLAEKEA 1388

  Fly  1296 DSSLHNSALLNRVSQGGETIYITLSAYLELE-------NCARPAI-----ITKDLSMVIYGRDAR 1348
            :.::..|.|        ||......|..|.:       |.||..:     :.|.:...: ..|..
Mosquito  1389 ELAIITSEL--------ETARAKCEALAEEQKTEHESYNSARQQLDQEIELLKQMVEQV-SADKA 1444

  Fly  1349 TGPR------SLKHLFSGQYRNPEANRLTGVYELALRRASEAGSPGVQRRQRRVLDTSSTYVRGE 1407
            |..|      |.:....||....|...|..:.||...||.:......|...:|.|:..:..::.|
Mosquito  1445 TVEREHSECHSRQQALQGQLEEREVEMLRYITELDALRAEQIRLVEQQNGVKRELEAKAAALQHE 1509

  Fly  1408 -ENLHG----WRPRGDSLIFDHQWELEKLTRLEEVGRMRHLLLLR------ERLGMDTNPNPTTK 1461
             ::|.|    .....::|:.: |.|.||..:.........||.||      |||        .|:
Mosquito  1510 LDSLQGNVSQLMNENEALLRE-QLEGEKSQQERTSADAEELLKLRSCRDESERL--------VTQ 1565

  Fly  1462 TEKDVCNLAARAATSPVHMVIPQSPQTPVKDPQQIIPEREYNQREQDLMLK---------CLKLV 1517
            .|:|:..:.|.     :.||     :|.:.:.::...|.|...||:...:|         ...|.
Mosquito  1566 LERDLATVRAE-----LEMV-----RTELLEEKRRRDEIEQTDRERSEAVKEETERLRHAITALE 1620

  Fly  1518 QGRYTKSEANDTQTQSDVSPSDEGCADM------TVSCISSNSMENNKFVI 1562
            ..:....||.| :.:.:::..:...|::      ..|.:.....|||...|
Mosquito  1621 DEKQRLQEATD-RLRVELTEKERHTAELESLQQQKESALDEMRKENNDLTI 1670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	134/365 (37%)
		Kinesin_assoc	355..498	CDD:465047	41/276 (15%)
		FHA_KIF1	474..574	CDD:438757	22/125 (18%)
		YhaN	<575..>666	CDD:443752	21/95 (22%)
		KIF1B	878..924	CDD:463574	13/71 (18%)
		DUF3694	1199..1347	CDD:463599	30/171 (18%)
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
LOC1277078	XP_061498142.1	None