Protein Alignment unc-104 and KIF19

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: XP_016879639.1
• Gene: KIF19 / 124602
• HGNCID: 26735
• Length: 1012
• Species: Homo sapiens
• Alignment Length: 1212
• Identity: 291/1212 - (24%)
• Similarity: 470/1212 - (38%)
• Gaps: 371/1212 - (30%)

  Fly     6 VAVRVRPFNSREIARESKCIIEMAGAT----------TAITNPKVPPNTSDSV--------KRFN 52
            ||:||||.:..|:..         |||          ..:.:|...|   |.:        |.:.
Human    14 VALRVRPISVAELEE---------GATLIAHKVDEQMVVLMDPMEDP---DDILRAHRSREKSYL 66

  Fly    53 FDYSYWSHDHHDADF-STQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQE 116
            ||.::        || :||.|||:...:.:::....|||..:||||.||.||:|||:|  .:|:.
Human    67 FDVAF--------DFTATQEMVYQATTKSLIEGVISGYNATVFAYGPTGCGKTYTMLG--TDQEP 121

  Fly   117 GIIPMICKDLFTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDL 181
            ||......|||..|::| ::|::|.|.:||:|||.|.:|||||| :.|.|.:||.......|..:
Human   122 GIYVQTLNDLFRAIEET-SNDMEYEVSMSYLEIYNEMIRDLLNP-SLGYLELREDSKGVIQVAGI 184

  Fly   182 SKLAVTDYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTE-KVSKIS 245
            ::::..:.::|..|:.:||:.||...|..|:||||||||..:  |.|:...:.|:..| :..::.
Human   185 TEVSTINAKEIMQLLMKGNRQRTQEPTAANQTSSRSHAVLQV--TVRQRSRVKNILQEVRQGRLF 247

  Fly   246 LVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALT- 309
            ::||||||||..|..:|.|:||||:||:||..||..|:||::..|.|       :|.||||.||
Human   248 MIDLAGSERASQTQNRGQRMKEGAHINRSLLALGNCINALSDKGSNK-------YINYRDSKLTR 305

  Fly   310 ------------WLLRENLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQI---VCKAVVNE 359
                        |..|::|||||:|.|||.||||...::|:.:||.||.|||.|   |.:.::|.
Human   306 LLKVPATAGPGHWAPRDSLGGNSRTVMIAHISPASSAFEESRNTLTYAGRAKNIKTRVKQNLLNV 370

  Fly   360 DAN----AKLIRELKEEIQKLRDLLKAEGIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVD-Q 419
            ..:    ..:|.:|:.|||:|:          ::.||.|.    :...:.|...|....:..: |
Human   371 SYHIAQYTSIIADLRGEIQRLK----------RKIDEQTG----RGQARGRQDRGDIRHIQAEVQ 421

  Fly   420 LQASE-------KLIAELNETWEEKLK-RTEEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPH 476
            |.:.:       :|..:|...::|::. |...:.::..|:  |:.:......:|:..:..:|:..
Human   422 LHSGQGEKAGMGQLREQLASAFQEQMDVRRRLLELENRAM--EVQIDTSRHLLTIAGWKHEKSRR 484

  Fly   477 LVNLNEDPNLSECLLYYIKEGLTR---LGTHEANVPQDIQLSGSHILKEHCTFENKNSTVTLLPH 538
            .:...|:.. .||   |.|:...:   .|..:.::.:..:::.:.........|.|.    |...
Human   485 ALKWREEQR-KEC---YAKDDSEKDSDTGDDQPDILEPPEVAAARESIAALVDEQKQ----LRKQ 541

  Fly   539 KDAI------IYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQARELRDKIETENEAENEVEK 597
            |.|:      :...||:|.|....:.||               |:.||:...:...:|.  |||.
Human   542 KLALEQRCRELRARGRRLEETLPRRIGS---------------EEQREVLSLLCRVHEL--EVEN 589

  Fly   598 TDTQQVDWNFAQCELLEKQGIDLKAEMKKRLDNLEE------QYKREKLQAD------QQFEEQR 650
            |:.|       ...||....:..:.|..:||:....      |.:|:.:.||      |:.||
Human   590 TEMQ-------SHALLRDGALRHRHEAVRRLEQHRSLCDEIIQGQRQIIDADYNLAVPQRLEE-- 645

  Fly   651 KTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNPMYESCWTAREAGLAAWAFRKWRY 715
             .||..:..|::...||:..|...:|.:.:|             .|......||
Human   646 -LYEVYLRELEEGSLEQATIMDQVASRALQD-------------SSLPKITPAG----------- 685

  Fly   716 HQFTSLRDDLWGNAIFLKEANAISVELKKKVQFQFTLLTDTLY---SPLPPELASTVAPVHQEDE 777
               |||..|          ::..||:         ||.:|..:   |.|||  .||.:..|...:
Human   686 ---TSLTPD----------SDLESVK---------TLSSDAQHLQNSALPP--LSTESEGHHVFK 726

  Fly   778 FGAPPVSKTLVAVEVTDTKNGATHHWSLEKLRYRLELMRQIYNVESPP-----SSMLFDTSGMEA 837
            .|                    |..|..:.           .:|.:||     |.:..:....::
Human   727 AG--------------------TGAWQAKS-----------SSVPTPPPIQLGSLVTQEAPAQDS 760

  Fly   838 LSGWI--SPPSQHPGQQAQLLPLEPPVESE----------------------RGRLTLANLIPSR 878
            |..||  ||.|   .:....:||......|                      .||..||   |:.
Human   761 LGSWINSSPDS---SENLSEIPLSHKERKEILTGTKCIWVKAARRRSRALGTEGRHLLA---PAT 819

  Fly   879 QRLELMREMYHNEAEMSPTSPDYNVESLTGGDPFYDRFPWFRMVGRSFIYLSNLLYPVPLVHKVA 943
            :|..|                  ::.||:.||   |..|                 |.||..|
Human   820 ERSSL------------------SLHSLSEGD---DARP-----------------PGPLACK-- 844

  Fly   944 IVNERGDVRGYLR---IAVQPVLDEESIDFNNGVKQSARLVFNEDDAKPKYRALNEKDDVQRYID 1005
                        |   ..:|....|:::..:.|...|..:..:.|..:|..|.
Human   845 ------------RPPSPTLQHAASEDNLSSSTGEAPSRAVGHHGDGPRPWLRG------------ 885

  Fly  1006 NGGLDSKLEELEDVDSGRGIDSNSASECHENSEEPGEHLQVGKEFTFRVTVLQATGIGAEYADIF 1070
                                ...|..:..|.|.|.....:..:.|       :.||.|..:.
Human   886 --------------------QKKSLGKKREESLEAKRRKRRSRSF-------EVTGQGLSHP--- 920

  Fly  1071 CQFNFLHRHE-EAFSTEPVKNSASGAPLGFYHVQNITVPVTK 1111
             :.:.|..|: |..|...:......|| |..|:..:|:|:.|
Human   921 -KTHLLGPHQAERISDHRMPVCRHPAP-GIRHLGKVTLPLAK 960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	144/387 (37%)
		Kinesin_assoc	355..498	CDD:465047	27/155 (17%)
		FHA_KIF1	474..574	CDD:438757	17/108 (16%)
		YhaN	<575..>666	CDD:443752	24/102 (24%)
		KIF1B	878..924	CDD:463574	8/45 (18%)
		DUF3694	1199..1347	CDD:463599
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
KIF19	XP_016879639.1	KISc_KIP3_like	11..359	CDD:276821	142/377 (38%)
		SMC_N	<374..>574	CDD:481474	39/238 (16%)
		YhaN	512..>670	CDD:443752	38/188 (20%)