Protein Alignment unc-104 and Kif1b

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: XP_038965095.1
• Gene: Kif1b / 117548
• RGDID: 621520
• Length: 1825
• Species: Rattus norvegicus
• Alignment Length: 1877
• Identity: 1000/1877 - (53%)
• Similarity: 1268/1877 - (67%)
• Gaps: 226/1877 - (12%)

  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSH-DHHDA 65
            :|||||||||||||||.::||||||:|.|.:|:|.|||   |..::.|.|:|||||||| ...|.
  Rat     4 ASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPK---NPKEAPKSFSFDYSYWSHTSPEDP 65

  Fly    66 DFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLFTRI 130
            .|::||.||.|||:|||.|:|:||||||||||||||||||||||:|||.|.||||.:|::||.:|
  Rat    66 CFASQSRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKI 130

  Fly   131 QDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIHDL 195
            .|...:|:.||||||||||||||||||||||||||||||||||||||||||||||||.|.||.||
  Rat   131 NDNCNEDMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADL 195

  Fly   196 IDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERADSTGA 260
            :|.|||||||||||||||||||||||||.|||::.|..|||:|||||||||||||||||||||||
  Rat   196 MDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKQDPETNLSTEKVSKISLVDLAGSERADSTGA 260

  Fly   261 KGTRLKEGANINKSLTTLGKVISALAEV---ASKKKNTKKADFIPYRDSALTWLLRENLGGNSKT 322
            ||||||||||||||||||||||||||||   .||.|..||.||||||||.|||||||||||||:|
  Rat   261 KGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRT 325

  Fly   323 AMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGI-E 386
            ||:||:|||||||||||||||||||||||.|.||:|||.||||:||||||:.:|:|||:|:|: :
  Rat   326 AMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGD 390

  Fly   387 VQEEDEL-----------------TKSTVIKSPTKSRNRNGSTTEM------------------- 415
            :.:.|.|                 .|...:.:....|..|.||..|
  Rat   391 IIDIDPLMDDYSGSGGKYLKDFQNNKHRYLLASENQRPGNFSTASMGSLTSSPSSCSLNSQAGLT 455

  Fly   416 -----------------AVDQLQASEKLIAELNETWEEKLKRTEEIRVQREAVFAEMGVAVKEDG 463
                             |:::|:.|||:||||||||||||::||.||::|||:.||||||::|||
  Rat   456 SVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDG 520

  Fly   464 ITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLSGSHILKEHCTFEN 528
            .|:||||||||||||||||||.:|||||||||:|:||:|..:|...|||.|||:||.:|||.|.:
  Rat   521 GTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRS 585

  Fly   529 -KNST----VTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQARELRDKIETE 588
             :|:|    |||.|.:.:..||||:::..|..|::|:|:|:||||||||.:|||||..|:|..:
  Rat   586 ERNNTGEVIVTLEPCERSETYVNGKRVAHPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPS- 649

  Fly   589 NEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEMKKRLDNLEEQYKREKLQADQQFEEQRKTY 653
                   .:|.::.|||.|||.|||||||||:|.||:|||..:|..|||||.:||...|:||..|
  Rat   650 -------AETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKREKEEADLLLEQQRLDY 707

  Fly   654 EARIDALQKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNPMYESCWTAREAGLAAWAFRKWRYHQF 718
            |:::.|||||||.:|:     ::.:.|:..:||:|   |     ||..|..||.||||||:.|||
  Rat   708 ESKLQALQKQVETRSL-----AAETTEEEEEEEEV---P-----WTQHEFELAQWAFRKWKSHQF 759

  Fly   719 TSLRDDLWGNAIFLKEANAISVELKKKVQFQFTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPV 783
            |||||.|||||::|||||||||||||||||||.|||||||||:||||..|......||.    |.
  Rat   760 TSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPVPPELLPTEMGKTHEDR----PF 820

  Fly   784 SKTLVAVEVTDTKNGATHHWSLEKLRYRLELMRQIYNVESPPSSMLFDTSGMEALSG-------- 840
            .:|:|||||.|.||||||:|||:||:.||:|||::|:......|...|.| ...::|
  Rat   821 PRTVVAVEVQDLKNGATHYWSLDKLKQRLDLMREMYDRAGEVGSNAQDDS-ETTMTGSDPFYDRF 884

  Fly   841 -WI----SPPSQHPGQQAQLLPLEPPVESERGRLTLANLIPSRQRLELMREMYHNEAEMSPTSPD 900
             |.    |.|..|.....:|....|..........:..|...:|  :.| |.:.:||.:..|..|
  Rat   885 HWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQ--DAM-EDFDDEAFVDDTGSD 946

  Fly   901 YNVES-----LTGGDPFYDRFPWFRMVGRSFIYLSNLLYPVPLVHKVAIVNERGDVRGYLRIAVQ 960
            ...|.     ..|.||||||.|||.:|||:|:|||||||||||:|:||||:|:|:|||:||:|||
  Rat   947 AGTEEGSELFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQ 1011

  Fly   961 PV-LDEESIDFNNGVKQS--ARLVFNEDDAKPKYRALNEKDDVQRYIDNGGLDSKLEELE----- 1017
            .: .|||:.|:.:|::||  |::.|:.:       ..|:.|.....:...||  .||||.
  Rat  1012 AIAADEEAPDYGSGIRQSGTAKISFDNE-------YFNQSDFPSAAMTRSGL--SLEELRIVEGQ 1067

  Fly  1018 -------------------DVDSGRGIDSNSASECHENSEEPGEHLQVGKEFTFRVTVLQATGIG 1063
                               |:.||..:|.....|..  |||.|.||::|..||||||||||:||.
  Rat  1068 GQSSEVISPPEEVNRMNDLDLKSGTLLDGKMVMEGF--SEEIGNHLKLGSAFTFRVTVLQASGIL 1130

  Fly  1064 AEYADIFCQFNFLHRHEEAFSTEPVKNSASGAPLGFYHVQNITVPVTKSFIEYLKTQPIMFKIFG 1128
            .|||||||||||||||:|||||||:||:..|:||||||||||.|.||:||::|:||:||:|::||
  Rat  1131 PEYADIFCQFNFLHRHDEAFSTEPLKNNGRGSPLGFYHVQNIAVEVTESFVDYIKTKPIVFEVFG 1195

  Fly  1129 HYQTHPLHKDAKQDFVSRP-PPRRMLPPSIPISQPVRSPKFGPLPCAPTSTVLAKHDVLVWFEIC 1192
            |||.||||... |:..|.| |.||..||.:|:|:||.:.|...:........::|:|:||||||.
  Rat  1196 HYQQHPLHLQG-QELNSPPQPSRRFFPPPMPLSRPVPATKLNTMNKTSLGQSMSKYDLLVWFEIS 1259

  Fly  1193 ELAPNGEYVPSVVEHSDDLPCRGLFLLHQGIQRRIRITIVHEPTTEVKWKDINELVVGRIRNTPE 1257
            ||.|.|||:|:||:|:..|||:|.|||||||||||.:||:||..:|:.|||:.|||||||||.||
  Rat  1260 ELEPTGEYIPAVVDHTAGLPCQGTFLLHQGIQRRITVTIIHEKGSELHWKDVRELVVGRIRNKPE 1324

  Fly  1258 SSDEQDEDACVLSLGLFPGEAL-------------EVPGDDRSFYRFEAAWDSSLHNSALLNRVS 1309
             .||...|| :|||.:...::|             ::|   |:||||||.||||||||.|||||:
  Rat  1325 -VDEAAVDA-ILSLNIISAKSLKSSHSSSRLFLDKDIP---RTFYRFEAVWDSSLHNSLLLNRVT 1384

  Fly  1310 QGGETIYITLSAYLELENCARPAIITKDLSMVIYGRDAR-TGPRSLKHLF-SGQYRNPEANRLTG 1372
            ..||.||:||||||||::|.:||:||||:.||.|.|||: :.||||::|| ||..::|::||:||
  Rat  1385 PYGEKIYMTLSAYLELDHCIQPAVITKDVCMVFYSRDAKISPPRSLRNLFGSGYSKSPDSNRVTG 1449

  Fly  1373 VYELALRRASEAGSPGVQRRQRRVLDTSSTYVRGEENLHGWRPRGDSLIFDHQWELEKLTRLEEV 1437
            :|||:|.:.::.||||:|||:|:|||||..||||||||.||||||||||.:||||||||..|.||
  Rat  1450 IYELSLCKMADTGSPGMQRRRRKVLDTSVAYVRGEENLAGWRPRGDSLILEHQWELEKLELLHEV 1514

  Fly  1438 GRMRHLLLLRERLG-------MDT-NPNPTTKTEKDVCNLAARAATSPVHMVIPQSPQT--PVKD 1492
            .:.||.||||||||       .|: :|:.::.|.....:::::.:|:.....|..|..:  ...|
  Rat  1515 EKTRHFLLLRERLGDSIPKSMSDSLSPSLSSGTLSTSTSISSQISTTTFESAITPSESSGYDSAD 1579

  Fly  1493 PQQIIPEREYNQREQDLMLKCLKLVQGRYTK--SEANDTQTQ---SDVSPSDEGCADMTVSCISS 1552
            .:.::      .||::|..|||:|:...:.:  |:.:.:.:.   ||:||...   |.:||..||
  Rat  1580 IESLV------DREKELATKCLQLLTHTFNREFSQVHGSISDCKLSDISPIGR---DPSVSSFSS 1635

  Fly  1553 NSMENNK---FVIRRRLCSPDRADAPNGWEAPAPATQPALPLRLY-------------------- 1594
            :::..:.   .::..|..|.|:...    ||.:.|:.|......:
  Rat  1636 STLTPSSTCPSLVDSRSSSMDQKTP----EANSRASSPCQEFEQFQIIPTVETPYLARAGKNEFL 1696

  Fly  1595 --VPELEEIRVSPVVARKGLLNVLEHGGSGWKKRWVIVRRPYVFIYRSEKDPVERAVLNLATAHV 1657
              ||::||:|...||::||.|:..|...|.|.|.:|:|||||||||.|:||||||.::||:||.|
  Rat  1697 NLVPDIEEVRAGSVVSKKGYLHFKEPLSSNWAKHFVVVRRPYVFIYNSDKDPVERGIINLSTAQV 1761

  Fly  1658 ECSEDQAAMVKIPNTFSVVTKHRGYLLQTLGDKEVHDWLYAINPLLAGQIKSRLARR 1714
            |.||||.||:|.||||:|.|||||.|||.|.||:::|||||.||||||.|:|:|:||
  Rat  1762 EYSEDQQAMLKTPNTFAVCTKHRGVLLQALNDKDMNDWLYAFNPLLAGTIRSKLSRR 1818

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	283/359 (79%)
		Kinesin_assoc	355..498	CDD:465047	90/196 (46%)
		FHA_KIF1	474..574	CDD:438757	60/104 (58%)
		YhaN	<575..>666	CDD:443752	48/90 (53%)
		KIF1B	878..924	CDD:463574	19/50 (38%)
		DUF3694	1199..1347	CDD:463599	92/160 (58%)
		PH_KIFIA_KIFIB	1602..1704	CDD:269939	64/101 (63%)
Kif1b	XP_038965095.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	283/359 (79%)
		Kinesin_assoc	358..555	CDD:465047	90/196 (46%)
		FHA_KIF1B	530..639	CDD:438779	62/108 (57%)
		GimC	662..>719	CDD:440992	35/56 (63%)
		KIF1B	845..892	CDD:463574	12/47 (26%)
		KIF1B	<956..975	CDD:463574	11/18 (61%)
		DUF3694	1266..1422	CDD:463599	92/160 (58%)
		PH_KIFIA_KIFIB	1710..1808	CDD:269939	63/97 (65%)