Protein Alignment unc-104 and KIF1C

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: NP_006603.2
• Gene: KIF1C / 10749
• HGNCID: 6317
• Length: 1103
• Species: Homo sapiens
• Alignment Length: 965
• Identity: 477/965 - (49%)
• Similarity: 614/965 - (63%)
• Gaps: 126/965 - (13%)

  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSH-DHHDA 65
            :||||||||||||:||.::::||::.|.|.||:|.|||   .:.|:.|.|.|||||||| ...|.
Human     4 ASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPK---QSKDAPKSFTFDYSYWSHTSTEDP 65

  Fly    66 DFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLFTRI 130
            .|::|..||:|||||||.|:|:|||||||||||||||||||||||||..|:||:|.:|:|||:|:
Human    66 QFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPGQQGIVPQLCEDLFSRV 130

  Fly   131 QDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIHDL 195
            .:.::..|.||||||||||||||||||||||::|:|||||||:|||||:||||||||.|.||.||
Human   131 SENQSAQLSYSVEVSYMEIYCERVRDLLNPKSRGSLRVREHPILGPYVQDLSKLAVTSYADIADL 195

  Fly   196 IDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERADSTGA 260
            :|.|||||||||||||||||||||||||.||||.||.:|.|.:|||||||||||||||||||:||
Human   196 MDCGNKARTVAATNMNETSSRSHAVFTIVFTQRCHDQLTGLDSEKVSKISLVDLAGSERADSSGA 260

  Fly   261 KGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGNSKTAMI 325
            :|.|||||||||||||||||||||||::.|||   :|:||||||||.|||||:|||||||:||||
Human   261 RGMRLKEGANINKSLTTLGKVISALADMQSKK---RKSDFIPYRDSVLTWLLKENLGGNSRTAMI 322

  Fly   326 AAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGIEVQEE 390
            ||:|||||||:|||||||||||.|||.|.|::|||.||:|||||:||:.:||:||.|:|:.....
Human   323 AALSPADINYEETLSTLRYADRTKQIRCNAIINEDPNARLIRELQEEVARLRELLMAQGLSASAL 387

  Fly   391 DEL-TKSTVIK-------------SPTKSRNRNGST-------------TEMAVDQLQASEKLIA 428
            :.| |:...::             ||:.....||..             .|.|:::||.:||:||
Human   388 EGLKTEEGSVRGALPAVSSPPAPVSPSSPTTHNGELEPSFSPNTESQIGPEEAMERLQETEKIIA 452

  Fly   429 ELNETWEEKLKRTEEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYY 493
            ||||||||||::||.:|::|||:.|||||||:|||.||||||||||||||||||||.:||||||:
Human   453 ELNETWEEKLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPHLVNLNEDPLMSECLLYH 517

  Fly   494 IKEGLTRLGTHEANVPQDIQLSGSHILKEHCTFE-----NKNSTVTLLPHKDAIIYVNGRKLVEP 553
            ||:|:||:|    .|..||:|:|..|.::||.|.     :....|||.|.:.|..||||:.:.||
Human   518 IKDGVTRVG----QVDMDIKLTGQFIREQHCLFRSIPQPDGEVVVTLEPCEGAETYVNGKLVTEP 578

  Fly   554 EVLKTGSRVILGKNHVFRFTNPEQARELRDKIETENEAENEVEK---TDTQQVDWNFAQCELLEK 615
            .|||:|:|:::||||||||.:|||||         .|.|..|..   ..::.|||||||.||||:
Human   579 LVLKSGNRIVMGKNHVFRFNHPEQAR---------LERERGVPPPPGPPSEPVDWNFAQKELLEQ 634

  Fly   616 QGIDLKAEMKKRLDNLEEQYKREKLQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPE 680
            ||||:|.||:|||.:||.||::||.:||...|:||                         .|:..
Human   635 QGIDIKLEMEKRLQDLENQYRKEKEEADLLLEQQR-------------------------LYADS 674

  Fly   681 DFHQEEDVYTNPMYESCWTAREAGLAAWAFRKWRYHQFTSLRDDLWGNAI--FLKEANAISVELK 743
            |...:.|      ..||            ...||.  .:|||:.|....:  .:|.....|...:
Human   675 DSGDDSD------KRSC------------EESWRL--ISSLREQLPPTTVQTIVKRCGLPSSGKR 719

  Fly   744 KKVQFQFTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNGATHHWSLEKL 808
            :..:..:.:..........|..| |:|.:..:      .|.:....|.:.|.::|.....:|..|
Human   720 RAPRRVYQIPQRRRLQGKDPRWA-TMADLKMQ------AVKEICYEVALADFRHGRAEIEALAAL 777

  Fly   809 RYRLELMRQIYNVESPPSSM------LFDTSGMEALSGWISPPSQHPGQQ-AQLLPLEPPVESER 866
            :.| ||.|.....:.|..:.      ::||.|.|...|..|......|.: |::..|...::...
Human   778 KMR-ELCRTYGKPDGPGDAWRAVARDVWDTVGEEEGGGAGSGGGSEEGARGAEVEDLRAHIDKLT 841

  Fly   867 G---RLTLANLIPSRQRLELMREMYHNEAEMSPTSPDYNVESLTGGDPFYDRFPW 918
            |   .:.|.|....|: |:.:|:.......:.|.:.|:..|:..||:     .||
Human   842 GILQEVKLQNSSKDRE-LQALRDRMLRMERVIPLAQDHEDENEEGGE-----VPW 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	264/356 (74%)
		Kinesin_assoc	355..498	CDD:465047	87/169 (51%)
		FHA_KIF1	474..574	CDD:438757	56/104 (54%)
		YhaN	<575..>666	CDD:443752	40/93 (43%)
		KIF1B	878..924	CDD:463574	10/41 (24%)
		DUF3694	1199..1347	CDD:463599
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
KIF1C	NP_006603.2	KISc_KIF1A_KIF1B	4..355	CDD:276816	264/356 (74%)
		Kinesin_assoc	352..522	CDD:465047	87/169 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..438		4/37 (11%)
		FHA_KIF1C	498..599	CDD:438780	56/104 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	808..828		5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	874..924		6/22 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	950..1103