Protein Alignment unc-104 and kif5c

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: XP_002935337.3
• Gene: kif5c / 100493873
• XenbaseID: XB-GENE-977474
• Length: 959
• Species: Xenopus tropicalis
• Alignment Length: 1069
• Identity: 278/1069 - (26%)
• Similarity: 434/1069 - (40%)
• Gaps: 293/1069 - (27%)

  Fly     3 SVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSHDHHDADF 67
            |:||..|.||.|..||.|..|.|....|..|.:..|..|         :.||..:.|:
 Frog     8 SIKVMCRFRPLNKAEIQRGDKFIPVFKGEDTVVVGPSKP---------YVFDKVFPSN------- 56

  Fly    68 STQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGR-QEEQQEGIIPMICKDLFTRIQ 131
            :||..||....:::::...||||..|||||||.:||::||.|: .:.|..||||.|..|:|..|.
 Frog    57 TTQEHVYSACAKQIVKDVLDGYNGTIFAYGQTSSGKTHTMEGKLHDHQMMGIIPRIAHDIFDHIY 121

  Fly   132 DTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIHDLI 196
            ..: ::|::.::|||.|||.:::||||: .:|.||.|.|.....|:|:..::..|:..:::.|:|
 Frog   122 SMD-ENLEFHIKVSYFEIYLDKIRDLLD-VSKTNLAVHEDKNRVPFVKGCTERFVSSPEEVMDVI 184

  Fly   197 DEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEK--VSKISLVDLAGSERADSTG 259
            |||...|.||.|||||.|||||::|.|...|.      |:.|||  ..|:.||||||||:...||
 Frog   185 DEGKANRHVAVTNMNEHSSRSHSIFLINIKQE------NVETEKKLSGKLYLVDLAGSEKVSKTG 243

  Fly   260 AKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGNSKTAM 324
            |:|..|.|..||||||:.||.|||||||      .||  ..:|||||.:|.:|:::||||.:|.:
 Frog   244 AEGAVLDEAKNINKSLSALGNVISALAE------GTK--THVPYRDSKMTRILQDSLGGNCRTTI 300

  Fly   325 IAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAK------------------LIRELKE 371
            |...||:..|..||.|||.:..|||.|.....||.:..|:                  :|:.|:.
 Frog   301 IICCSPSIFNEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKDKTKSLKNIIQHLEM 365

  Fly   372 EIQKLRDLLKAEGIEVQE-------------------EDELTKSTVIKSPTKSR----------- 406
            |:.:.|   :.|.:.|.|                   ::.|..:|.|.|..|.:
 Frog   366 ELNRWR---RGEAVPVDEQTSAKDQKTLEPCDNTPVIDNGLVGATNISSEEKKKYDEDIASLYGQ 427

  Fly   407 --------NRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQREAVFAEMGVAVKE-- 461
                    |:.....|....|:...|:|:|.....:|:..:....::::.:|...|    |||
 Frog   428 LDDKDDEINQQSQLIEKLKQQMLDQEELLASTRRDYEKIQEELTRLQIENDAAKDE----VKEVL 488

  Fly   462 ---DGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLSGSHILKEH 523
               :.:.|. :..|..    .:.:...|:|.|...:.:..|.|...:..:.|         |:|.
 Frog   489 QALEELAVN-YDQKSQ----EVEDKTKLNEQLSEELTQKTTNLTVTQRELSQ---------LQEL 539

  Fly   524 CTFENKNSTVTL-LPHKD--------------AIIYVNGRKLVEPEVLKTGSRVILG--KNHVFR 571
            ...:.|.:|..| |..||              .:..|||  ::|.|.  |.:|:.:.  |:.|..
 Frog   540 SNHQRKRTTEILNLLLKDLGEIGGIVGTNDVKTLAEVNG--VIEEEF--TMARLYISKMKSEVKS 600

  Fly   572 FTNPEQARELRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQG-------IDLKAEMKKRLD 629
            ..|  ::::|.......|...|..||        ..|.|:||..|.       .|....|::|..
 Frog   601 LVN--RSKQLESAQIEANRKINASEK--------ELAACQLLSSQHEAKIKSLTDYMQNMEQRRR 655

  Fly   630 NLEE--------------QYKREKLQ---------------------ADQQFEEQRKTYEARIDA 659
            .|||              |.|..|:.                     .:||.|..|:.::.::..
 Frog   656 QLEEAQDALNEELARLHAQEKMHKVSFQDKEKEHLTRLQDAEEIKKTLEQQMESHREAHQKQLSR 720

  Fly   660 LQKQVEEQSMTM------------------SMYSSYSPEDFHQEED----VYTNPMYESCWTARE 702
            |:.::||:...:                  |.|.....|:..:|||    |..|...|.   :||
 Frog   721 LRDEIEEKQKMIDDLKDLNQKLQLQLDKLTSDYEKLKTEEEQREEDLQKLVLLNEKREQ---SRE 782

  Fly   703 --AGLAAWAFRKWR-YHQFTSLRDDLWGNAIFLKEANAISVELKKKVQF-------------QFT 751
              .||.....|:.: .|....|         |:::   :::.::|:|:.             :.:
 Frog   783 DLKGLEETVARELQTLHNLRKL---------FIQD---LALRVQKRVELDSDNGGGSAAQKQKIS 835

  Fly   752 LLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNGATHHWSLEKLRYRLELMR 816
            .|.:.|         ..:..||           |.||       ::.|.....|.||..||....
 Frog   836 FLENNL---------EQLTKVH-----------KQLV-------RDNADLRCELPKLEKRLRATA 873

  Fly   817 QIYNVESPPSSMLFDTSGMEALSGWISPPSQHPGQQAQLLPLEPPVESERGRL-TLANLIPSRQR 880
            :                .::||.|.:....::..:..:....|.....|..|. .:|...||.|.
 Frog   874 E----------------RVKALEGALKEAKENAMRDRRRYQQEVDRIKEAVRAKNIARRAPSAQI 922

  Fly   881 LELMREMYHNEAEMSPTSPDYNVESLTGG 909
            .:.:|..::..:  |||:    |.|:.||
 Frog   923 AKPIRPGHYPAS--SPTA----VHSIRGG 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	149/357 (42%)
		Kinesin_assoc	355..498	CDD:465047	32/203 (16%)
		FHA_KIF1	474..574	CDD:438757	23/116 (20%)
		YhaN	<575..>666	CDD:443752	24/132 (18%)
		KIF1B	878..924	CDD:463574	9/32 (28%)
		DUF3694	1199..1347	CDD:463599
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
kif5c	XP_002935337.3	KISc_KHC_KIF5	6..327	CDD:276820	148/350 (42%)
		EnvC	452..>676	CDD:443969	52/255 (20%)
		SMC_prok_B	580..>912	CDD:274008	71/401 (18%)
		Khc_CBD_cc	836..905	CDD:467880	17/111 (15%)