DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-104 and kif14

DIOPT Version :9

Sequence 1:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster
Sequence 2:	XP_004913798.2	Gene:	kif14 / 100493263	XenbaseID:	XB-GENE-981231	Length:	1609	Species:	Xenopus tropicalis

Alignment Length:	1017	Identity:	354/1017 - (34%)
Similarity:	501/1017 - (49%)	Gaps:	193/1017 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKR--FNFDYSYWSHDHHDA 65
            :|.||||||||:.||:..::..::.|.|..|.:.:|       ||.:.  |.:|:|:||.:....
Frog   346 AVTVAVRVRPFSKREVNEKAVQVVFMNGQETTVQHP-------DSKQNYIFCYDFSFWSFEKSQP 403

  Fly    66 DFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLFTRI 130
            .|..|:.||:.:...:|:.|..|||.|:|||||||:||||||||...|  .||||..|.|||:||
Frog   404 SFVGQASVYEKLAVPLLEWSLLGYNTCLFAYGQTGSGKSYTMMGFDGE--PGIIPRFCSDLFSRI 466

  Fly   131 QDTETDDLKYSVEVSYMEIYCERVRDLL-----NPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQ 190
            |.|....|.:.:|:||.|:|.|::.|||     |.:.|..|:||||||.||||||||...|:.:|
Frog   467 QATMKQKLSFHLEISYFEVYNEKIHDLLIFKAENGQKKQPLKVREHPLTGPYVEDLSMNVVSSFQ 531

  Fly   191 DIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEK--VSKISLVDLAGSE 253
            ||...::.|||.|..|||.||:.|||||:|||:..||.:.:.:.....:.  .|:|:||||||||
Frog   532 DIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEYVDGQEHDHRITSRINLVDLAGSE 596

  Fly   254 RADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGG 318
            |..:....|.|||||.:|||||.|||||||||:|    ...|:|..|||||:|.|||||:|:|||
Frog   597 RCSTAQTSGERLKEGVSINKSLLTLGKVISALSE----NSQTRKKTFIPYRESVLTWLLKESLGG 657

  Fly   319 NSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAE 383
            ||||:|||.||||..|.:|||||||||.:|:.|:..|.||||.|||:|||||.||:|    :||.
Frog   658 NSKTSMIATISPAATNMEETLSTLRYAKQARLIINVAKVNEDLNAKIIRELKAEIEK----MKAS 718

  Fly   384 GIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQR 448
            .:..:.:|.          .|.|..:...|.:.: :|...|:.::||...|::||::.|:.:...
Frog   719 QLSAKNKDS----------EKYRQCHQEVTSLKL-KLCQQEREMSELRRAWKDKLEQAEQRKKVE 772

  Fly   449 EAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQ 513
            .....:.|:..|.|         .:.|:||||||||.|||.|||.||||.|.:|.::|....|||
Frog   773 MQELQKAGITFKMD---------NRLPNLVNLNEDPQLSEMLLYMIKEGQTTVGKYKAGSSHDIQ 828

  Fly   514 LSGSHILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQA 578
            |||:.|.::||...|..:.|.:.|..||..||||.::....:|..|.|:|||.:|.||..:|.:.
Frog   829 LSGALIAEDHCIITNNENIVCIKPFGDAKTYVNGNQISGSTILHHGDRLILGGDHYFRVNHPMEV 893

  Fly   579 RELRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEMKK-RL---DNLEEQYKREK 639
            ..|           |...:......|:.||:.|||..|...|..|::: ||   :.:.|..:..|
Frog   894 NRL-----------NATTQVSDGPKDYEFAKNELLSAQRSQLAEEIEEARLRAKEEMMEGIQIAK 947

  Fly   640 LQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPE-----------DFHQEEDVYTNPM 693
            ..|.|:...|:..||.:|..|:.|::::|....:....|..           ..|.:::|..|..
Frog   948 EMAQQELTSQKFAYEEKIRDLEAQLKKESQHKELQEMNSQRATTRIQELEEMKIHLQQEVQFNKK 1012

  Fly   694 ---YESCWT-------------------------AREAGLAAWAFRKWRYHQFTSLR-DDLWGN- 728
               .|:..|                         |:|..:    .::.|..|..::. ...|.|
Frog  1013 RLEMETLATKQALEDHNVRHAKILQALEAEKQKIAKEVQM----LQRERNSQDRAMAVQPTWNNM 1073

  Fly   729 --AIFLKEANAISVELKKKVQFQFTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKTLVAVE 791
              ::.::|||:||.:|||...|....:||....|..|                        |.::
Frog  1074 KLSVMIQEANSISSKLKKHTVFSRHDVTDKENLPTNP------------------------VQIQ 1114

  Fly   792 VTDTKNGATHHWSLEKLRYRLELMRQIY-NVESPPSSMLFDTSGMEALSGWISPPSQHPGQQAQL 855
            |.:.|.|...:|||||..|:|..|:.:| |..|.....:|...|.|    |
Frog  1115 VKNLKLGIVTYWSLEKFEYKLAAMKDLYENHGSTKDDDVFYDPGDE----W-------------- 1161

  Fly   856 LPLEPPVESERGRLTLANLIPSR--QRLELMRE------MY-------------HNEAEMSPTSP 899
               ||         .|:|...||  :|..||:.      :|             |....|:.:|.
Frog  1162 ---EP---------DLSNTSVSRFSRRKSLMKNRRISGCLYEIRVHPIQSLQSGHASGLMNKSSS 1214

  Fly   900 DYNVESLTGGDPFYDRFPW---------FRMVGRSFIYLSNL 932
            ..:..|....:|.....|.         ...:|||.:..||:
Frog  1215 FLSCSSSVSSNPSDSHLPGICKDLIASSLDYLGRSHVDESNM 1256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	183/363 (50%)
		KISc	3..358	CDD:214526	183/363 (50%)
		Kinesin_assoc	355..498	CDD:292801	51/142 (36%)
		FHA	475..574	CDD:238017	49/98 (50%)
		KIF1B	878..923	CDD:289208	11/74 (15%)
		DUF3694	1246..1347	CDD:289256
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
		PH	1607..1700	CDD:278594
kif14	XP_004913798.2	KISc_KIF1A_KIF1B	347..697	CDD:276816	183/362 (51%)
		Kinesin_assoc	694..812	CDD:406567	50/141 (35%)
		FHA	792..889	CDD:238017	48/96 (50%)
		DUF5401	<910..>1065	CDD:375164	31/158 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920