Protein Alignment unc-104 and LOC100491511

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: XP_031749449.1
• Gene: LOC100491511 / 100491511
• XenbaseID: XB-GENE-29080727
• Length: 2330
• Species: Xenopus tropicalis
• Alignment Length: 1637
• Identity: 417/1637 - (25%)
• Similarity: 651/1637 - (39%)
• Gaps: 508/1637 - (31%)

  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMAGATTAI-TNPKVPP-NTSDSVKRFNFDYSYWSHDHHD 64
            |:|:|||||||.|.||..:....:|.|:|..|.: :|..|.| ......|.|.:|:.:||.|..|
 Frog     5 SNVRVAVRVRPMNQREKEKHPVGVISMSGTKTILQSNATVSPGKVQKGPKEFTYDHCFWSADDSD 69

  Fly    65 AD-FSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLFT 128
            .| ::.|..|:|.:.|..:::.:.|||||||||||||:||:||||||.:|  .|:||..|:.|..
 Frog    70 PDTYAGQEEVFKTLEEGTIENIYQGYNVCIFAYGQTGSGKTYTMMGRDDE--PGLIPRFCRALLN 132

  Fly   129 RIQDTETDDLKYSVEVSYMEIYCERVRDLLN-PKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDI 192
            |......     .||:||||||.|:|||||. .|:|..|.||||.:||||||.||:.||:.::||
 Frog   133 RKSKGTV-----RVELSYMEIYNEKVRDLLELKKSKKELSVREHNILGPYVEGLSQHAVSTWEDI 192

  Fly   193 HDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERADS 257
            ..|:..|||.||.|||.|||.||||||:||:..||...:..:..:.|..||.:||||||||||..
 Frog   193 KLLLLAGNKCRTTAATKMNEESSRSHAIFTLAITQMFPNQASGTSKELHSKFNLVDLAGSERASK 257

  Fly   258 TGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGNSKT 322
            :||:|.:|.|..|||||||:||::||:|||.    |..:.:.::.||:|.|||||:.:|||||||
 Frog   258 SGAQGKQLVESGNINKSLTSLGRIISSLAEC----KGRRSSSYVSYRESVLTWLLKNSLGGNSKT 318

  Fly   323 AMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGIEV 387
            .|:|.||||:.||.||.|||.||:||::||.:|.||||...|.:..|::|:|.|::.||.  .:.
 Frog   319 VMLATISPAEDNYGETHSTLVYAERARKIVNQATVNEDTKCKAVATLQKEVQNLKEQLKR--AKS 381

  Fly   388 QEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQREAVF 452
            |:..||.                       .:|:.||.|:.:||.:||||||:|||.....:...
 Frog   382 QQSPELQ-----------------------SKLKESENLLKQLNLSWEEKLKKTEENAKLMQKYL 423

  Fly   453 AEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLSGS 517
            ..||::|...||...    |:...|||||.||..::.||||:.:. .::|   |...||.||:|.
 Frog   424 ESMGISVDASGIKCA----KEQCCLVNLNPDPESNDYLLYYLTDH-NKIG---AGSSQDFQLTGP 480

  Fly   518 HILKEHCTFENKNSTVTLLPHKDAIIY--------VNGRKLVEPEVLKTGSRVILGKNHVFRFTN 574
            .|.:|||       .:|:.|..|..:.        |||..:.|...|....::.||.|:.|....
 Frog   481 GIEEEHC-------VITMTPDGDVFLVPSTKTETKVNGALVQESIQLYHEDKINLGLNYSFILNQ 538

  Fly   575 PEQARELRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEMKKRLDNLEEQYKREK 639
            |:: |:.....|.:::.|.....||.:.::                 ....|....::||:...:
 Frog   539 PKK-RQPNSLSENKHKVEKNEMSTDHESIN-----------------ESNPKHESGIQEQHPYYQ 585

  Fly   640 LQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNPMYESCWTAREAG 704
            |...|.                   ::..:|         :.||      .||..|...|..
 Frog   586 LSGSQD-------------------DDNELT---------KTFH------INPKKEEISTES--- 613

  Fly   705 LAAWAFRKWRYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQFQFTLLTDTLYSPLPPELASTV 769
                  |....|..:|:...|   |:..|...:::     ::|..||.|.:.|
 Frog   614 ------RSHDSHSTSSIEKVL---ALLQKSQESLT-----ELQQNFTNLVEKL------------ 652

  Fly   770 APVHQEDEFGAPPVSKTLVAVEVTDTKNGATHHWSLEKLRYRLELMRQIYNVESPPSSMLFDTSG 834
                         .||.|:..:                                       |.:|
 Frog   653 -------------ESKQLITQQ---------------------------------------DCAG 665

  Fly   835 MEALSGWISPPSQHPGQQAQLLPLEPPVESERGRLTLANLIPSR------QRLELMREMYHNEAE 893
            :|             .::..:|..|          .|.|:|..:      :.|:|:.:   ::.:
 Frog   666 LE-------------NKEDVVLKYE----------ILLNIIAEKGENACTEFLDLLGK---DKVD 704

  Fly   894 MSPTSPD----YNVESLTGGDPFYDRFPWFRMVGRSFIYLSNLLYPVPLVHKVAIVNERGDVRGY 954
            |:..:.|    .|.|:.|..|
 Frog   705 MNKDNDDDRKEQNTETETAKD-------------------------------------------- 725

  Fly   955 LRIAVQPVLDEESIDFNNGVKQSARLVFNEDDAKPKYRALNEKDDVQRYIDNGGLDSKLEELEDV 1019
               ..||         ||...:.|       :.:....|||||.||.: .:||.      |.|:.
 Frog   726 ---QSQP---------NNDKNEVA-------EKEETTEALNEKSDVAK-TENGA------EREEE 764

  Fly  1020 DSG-------RGIDSNSASECHENSEEPGEHLQVGKEFTFRVTVLQATGIGAEYADIFCQFNFLH 1077
            ::|       .....||..||.|      |:..:.|:..:|              |:..:.|.
 Frog   765 NTGPSKNHSDNDTKKNSEDECTE------ENTSIDKKTLYR--------------DLLKKMNM-- 807

  Fly  1078 RHEEAFSTEPVKNSASGAPLGFYHVQNITVPVTKSFIEYLKTQPIMFKIFGHYQTHPLHKDAKQD 1142
                    :|            |.::|:|:.      :.|:......:...::|    .|.|..:
 Frog   808 --------DP------------YEMKNLTLQ------DILQIDQECLEKMDNWQ----RKSAAMN 842

  Fly  1143 FVSR-----PPPRRMLPPSIPISQPVR----------SPKFGPLP-------CAPTSTVLAKHDV 1185
            |:.:     ...|.::..|...|:..:          |....||.       |   |.:..:.::
 Frog   843 FIHKIIALNGTARSIITSSENESEDSQDDPDDVTCDSSDSVHPLDVLCLVLHC---SDLFLQQEI 904

  Fly  1186 LVWFEICELAPNGEYVPSVVEHSDDLPCRGLFLLHQGIQRRIRITIVHEPTTEVKWKDINELVVG 1250
            ::...:|:.|     ||.::...|...|  .|:| .|::..::           :|
 Frog   905 ILKMSMCQFA-----VPFLLPAVDGPGC--TFML-WGMRDIVK-----------RW--------- 941

  Fly  1251 RIRNTPESSDEQDEDACVLSLGLFPGEALEVPGDDRSFYRFEAAWDSSLHNSALLNRV---SQGG 1312
            |.::..|:.....|:...:|:..|            ||.||   .:|.|..|.:||:|   :|..
 Frog   942 RPQSLAETKGYMQENLVQISMPTF------------SFVRF---GESKLSKSTILNQVLSPTQQT 991

  Fly  1313 ETIYITLSAYLELENCARPAIITKDLSMVIYGRDARTGPRSLKHLF-SGQ-----------YRNP 1365
            :..::    :..:|.    |.:|:::|         .|...:...| :|:           :.|.
 Frog   992 QDFFV----HSNMEG----ADVTREIS---------EGLVEISWYFPAGKGNSDIFPEPVAFANL 1039

  Fly  1366 EANRLTGVYELA-LRRASEAGSPGVQRRQRRVLDTSSTYVRGEENLHGWRPRGDSLIFDHQWELE 1429
            ..|....:.|.| |.:.|......||...:.::|..|.|...:.|.        .:||....:::
 Frog  1040 HGNLKDSLNEFAFLTQISSTVFIFVQDINKNLIDFLSQYENSQANF--------VIIFKDSRKID 1096

  Fly  1430 KLTRLEEVGRMRHLLLLRERLGMDTNPNPTTKTEK-------------------DVCNLAARAAT 1475
            |.|.|..|..:.          .::..:..|..:|                   |:..:|.:...
 Frog  1097 KDTGLTNVTVVH----------FNSKASGATIAKKIRAATTDFIKKKFRALSLEDMAEIAPKLRI 1151

  Fly  1476 SPVHMVIPQSPQTPVKDPQQIIPE----REYNQ---REQDLMLKCLKLVQGRYTKSEANDTQTQS 1533
            |....||  ..|....|.:.|..|    .||.:   |.|..:.|..:|.:......:..|.:|.|
 Frog  1152 SVDENVI--ECQNAKADAKAIADEIKDVAEYKKDTMRLQRHLWKKAELEKEMCQMKKQGDKRTDS 1214

  Fly  1534 DVSPSDEGCADM 1545
            ..|...:.||::
 Frog  1215 YKSELQKQCAEI 1226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	182/359 (51%)
		Kinesin_assoc	355..498	CDD:465047	47/142 (33%)
		FHA_KIF1	474..574	CDD:438757	34/107 (32%)
		YhaN	<575..>666	CDD:443752	11/90 (12%)
		KIF1B	878..924	CDD:463574	8/55 (15%)
		DUF3694	1199..1347	CDD:463599	28/150 (19%)
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
LOC100491511	XP_031749449.1	Motor_domain	5..354	CDD:473979	182/359 (51%)
		Kinesin_assoc	<384..463	CDD:465047	34/105 (32%)
		FHA	441..549	CDD:469597	36/119 (30%)
		PRK08581	544..>796	CDD:236304	70/485 (14%)
		CARD	641..701	CDD:260018	18/149 (12%)
		P-loop containing Nucleoside Triphosphate Hydrolases	1387..>1516	CDD:476819