Protein Alignment unc-104 and kif16b

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: XP_012819297.1
• Gene: kif16b / 100489716
• XenbaseID: XB-GENE-948787
• Length: 1837
• Species: Xenopus tropicalis
• Alignment Length: 2015
• Identity: 542/2015 - (26%)
• Similarity: 822/2015 - (40%)
• Gaps: 592/2015 - (29%)

  Fly     1 MSSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTS-----DSVKRFNFDYSYWSH 60
            |:||||||||||.|.||...|:|.||||.|..|.|||.|:|...|     :..|.|.:|:||:|.
 Frog     1 MASVKVAVRVRPMNRREKDLEAKFIIEMEGKKTTITNIKMPDGISGDLGRERTKTFTYDFSYFSV 65

  Fly    61 DHHDADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKD 125
            |..:.|:::|..|:||:|.::||.:|:|||.|||||||||:||||||||...:  .|:||.||:.
 Frog    66 DSKNIDYASQERVFKDLGTDVLQSAFEGYNACIFAYGQTGSGKSYTMMGNPGD--SGLIPRICEG 128

  Fly   126 LFTRI-QDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKG--NLRVREHPLLGPYVEDLSKLAVT 187
            ||:|| :.|...|..:..||||:|||.|||||||..|:..  ||||||||..|||||||||..|.
 Frog   129 LFSRIAETTRWGDASFRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYVEDLSKHLVQ 193

  Fly   188 DYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGS 252
            :|.|:.:|:|.||..||.|||.||:.||||||:|||.|||.:.|  ..:..|.||||.|||||||
 Frog   194 NYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTINFTQAKFD--AEMPCETVSKIHLVDLAGS 256

  Fly   253 ERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKN---TKKADFIPYRDSALTWLLRE 314
            ||||:|||.|.|||||.||||||.|||.||||||:::....|   .||..|:|||||.|||||::
 Frog   257 ERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANHLAKKKQVFVPYRDSVLTWLLKD 321

  Fly   315 NLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDL 379
            :|||||||.|||.||||||||.|||||||||:|||.|:.|..:|||||.||||||:.||.:|:.|
 Frog   322 SLGGNSKTIMIATISPADINYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIARLKAL 386

  Fly   380 LKAEGIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTEEI 444
            | |:|.::         .::.|||.....         ::||.:|..:.||.:.|..|...|:.|
 Frog   387 L-AQGNQI---------ALLDSPTALSME---------EKLQQNEARVEELTKEWTNKWNETQNI 432

  Fly   445 RVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVP 509
                   ..|..:|::::||  ||....:.|||:.:::|...:..:||::|||.|.:|..:|...
 Frog   433 -------LKEQTLALRKEGI--GVVLDSELPHLIGIDDDLLSTGIILYHLKEGRTYVGREDAAAD 488

  Fly   510 QDIQLSGSHILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTN 574
            |||.|.|..:..|||.|||.:.||||:|...:...|||.::.|...|..|:.::||:.::|||.:
 Frog   489 QDIVLHGLDLESEHCIFENLSGTVTLIPLNGSQCSVNGVQIQESTQLNQGAVILLGRTNMFRFNH 553

  Fly   575 PEQARELRDKIETENEAENEVEKTDTQQVDWNFAQCE-----LLEKQGIDLKAEMKKRLDNLEEQ 634
            |::|.:||:|.::...:...:..||..:      .||     :|...|::.:.:.::.|:.||.:
 Frog   554 PKEAAKLREKRKSGLLSSFSLSMTDLSK------SCENLSAVMLYNPGLEFERQQREELEKLENK 612

  Fly   635 YKREKLQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNPMYESCWT 699
            .|..|     :.||::|..:|.::.:|::||.|.....:...:..:   |||.:
 Frog   613 RKLIK-----EMEEKQKYEKAELEKMQQEVESQRKETEIVQLHIRK---QEESL----------- 658

  Fly   700 AREAGLAAWAFRKWRYHQFTSLRDDLWGNAIFLKE---ANAISVELKKKVQFQFTLLTDTLYSPL 761
                        |.|.....|...||....|..:|   .....:||:||.|
 Frog   659 ------------KRRSLDIESRLQDLLAEKIKFEEERLREQQEIELQKKKQ-------------- 697

  Fly   762 PPELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNGATHHWSLEKLRYRLELMRQIYNVESPPS 826
                        ||:.|                           .|::..|:.:::::|.|....
 Frog   698 ------------QEESF---------------------------IKVQEELQRLQELHNTEKGEK 723

  Fly   827 SMLFDTSGMEALSGWISPPSQHPGQQAQLLPLEPPVESERGRLTLANLIPSRQR----------- 880
            ..:|  ..:|.|..  ....|:...:|:...||   |.||.:|.|...:..:.|
 Frog   724 MEIF--RELEKLKK--EKDDQYLKLEAEKKRLE---EQEREQLKLVFRLEEQLREKQEMILLFER 781

  Fly   881 ------------LELMRE--MYHNEAEMSPTSPDYNVESLTGGDPFYDRFPWFRM-VGRSFIYLS 930
                        ||.:||  :...||..........||..|..   |..|.  || |.:..:...
 Frog   782 GDVSRLEEEIGVLEDVREDLLRAKEARSEGEGDPEEVEKATNK---YTEFK--RMQVDKLSVLEG 841

  Fly   931 NLLYPVPLVHKVAIVNERGDVRGYLRIAVQPV--------LDEESIDFNNGVKQSARLVFNEDDA 987
            :|......:.|    ..:.|.....|:.:..|        .||.|:......::...:...|:..
 Frog   842 DLHRQTDCLEK----EIKADHDTLSRLCLSNVENTELHKTEDESSLVTPQIAEELEMIKQTENKI 902

  Fly   988 KPKYRAL------------NEKDDVQRYIDNG--GLDSKLEELE-DVDSGRGIDSNSASECHENS 1037
            ..|.|.|            :||......:::|  |||..|.::| :::.    .::..::...:|
 Frog   903 HCKERQLKYINQTHLPALFDEKQRASEILNSGLLGLDKTLYQIEKEIEE----KADQLAQFRASS 963

  Fly  1038 EEPGEHLQVGKEFTFRVT------------VL------QATGIGAEYADIFCQFNFLHRH----- 1079
            ::. :.||...|||..:.            :|      |...:....|.:..:.:.|.||
 Frog   964 DQL-QQLQETFEFTTNIARQEEKVRRKEKEILESREKQQREALEQAVAKLERRHSALQRHSTIDV 1027

  Fly  1080 ---EEAFSTEPVKNSASGAPLG-----------------FYHVQ------NITVPVTKSFIEYLK 1118
               |:......:.||...|.|.                 .:.:|      ::..|::||....::
 Frog  1028 EIEEQKCKLAALNNSKEQAGLQATLEAEQKALEQDRERLAHEIQQLKQKIHVADPLSKSLSGSVE 1092

  Fly  1119 TQPIM-------FKIFGHYQTHPLHKDAKQDFVSRPPPRRMLPPSIPIS---------------- 1160
            .:|.:       .|...|..|  |:.|....::.....||:  .:|.:|
 Frog  1093 EKPSLVNSPASPVKSQSHLLT--LNDDRIHAYIEEEVQRRL--QNINMSCDNLNGLSLTSSADFG 1153

  Fly  1161 -----------------QPVRSP-KFGPLPCAPTSTVLAKHDVLVWFEICELAP----------- 1196
                             :.|:.| ||..:|...|.|....|| |...|...|||
 Frog  1154 MSSDAFLNGATQRKLKYENVQHPEKFCNVPMPGTKTTSVLHD-LERPECRHLAPVTDALSDPSKI 1217

  Fly  1197 --------------NGEYVPSVVEHSD---DLPCRGLFLLHQGIQRRIRITIVHEPTTEVKWKDI 1244
                          .|.|..|:.|:.|   |..|                             ::
 Frog  1218 FSGSQEKYFSKGNEKGIYGSSISEYFDVLADTKC-----------------------------EL 1253

  Fly  1245 NELVVGRIRNTPESSDEQDEDACVLSLGLFPGEALEVPGDD-----------RSFYRFEAAWDSS 1298
            ::|....|.::..|.:      |.      |..:.::|...           :.|.:.|:.| :|
 Frog  1254 SQLFSNNISSSKGSHE------CA------PCASFQLPQQSQVKLSESALCHQDFLKTESDW-TS 1305

  Fly  1299 LHNSALLNRVSQGGETIYITLSAYLELENCARPAIITKDLSMVIYGRDARTGPRS--LKHL---- 1357
            :|....|.||:.  :|:...|.   |:.:|  ...:.:::|  :|...:...|::  .:|.
 Frog  1306 MHQMPSLVRVTP--DTMQSKLK---EIGHC--ETNLKENVS--LYQSHSSILPKTPGYQHTDQEE 1361

  Fly  1358 FSGQYRNPE---------------ANRLTGVYELALRRASEAGSPGVQRRQRRVLDTSSTYVRGE 1407
            |.|...|.|               :|:|:.:|    ::...|...||..:.::..:...:.|:..
 Frog  1362 FDGNKVNSEEADTFIPDNTVFSTFSNKLSYLY----KKTHLATIKGVVDQAKQFCNKQDSRVKFS 1422

  Fly  1408 ENLHGWRPRGDSLIFDHQWELEKLTRLEEVGRMRHLLLLRERLGMDTNPNPTTKTEKDVCNLAAR 1472
            :.|        |||.|.|..             ::|     .|.:..|.:|...||
 Frog  1423 QVL--------SLIKDIQVS-------------KYL-----PLSVTINDDPCASTE--------- 1452

  Fly  1473 AATSPVHMVIPQSPQTPVKDPQ--QIIPEREYNQREQDLMLKCLKLVQGRYTKSEANDTQTQSDV 1535
                        ||  |||..:  ..:|....:......:|..|...||          .|.||.
 Frog  1453 ------------SP--PVKHVKLYTFVPSNMGSAEPGQPLLCELSTRQG----------ITASDE 1493

  Fly  1536 SPSDEGCADMTV----------------------------SCISSNSMENNKFVIRRRLCSPDRA 1572
            ....|.||:..|                            ..:....::...|.....||.   |
 Frog  1494 DNGQELCANTKVFSHPFVQFLKEHLKLQNSLPIELLEYLSHTLPDMQIDKKTFKSAYWLCV---A 1555

  Fly  1573 DAPNGWEAPAPA----------------TQPALPLRLYVPELEEIRV------------------ 1603
            :.|.  ..|.|:                |.|:|.:.|.:..|:|||:
 Frog  1556 NCPQ--SEPQPSCMLLFSSHIHVIDFSNTVPSLLITLPLSTLQEIRICFGGQSVLFIGYDQEPGF 1618

  Fly  1604 -----SPVVARKGLLNVL-----EHGGSGWKKRWVIVRRPYVFIYRSEKDPVERAV-LNLATAHV 1657
                 |.|..:|...:::     |.....:|...:::           ||.::.:: .|:..:.:
 Frog  1619 MVYTFSGVYTQKMCGDIMQSIISESDYDKYKNHSLLI-----------KDLMQLSLDWNVELSDI 1672

  Fly  1658 ECSEDQAAMVKIPNTFSVVTKHRGYLLQ--------TLGDKEVHDWLYAINPLLAGQIKSRLARR 1714
            .||..    :|:.:.|.|......|||.        :|||         ||.|....:|...|.|
 Frog  1673 VCSNG----LKLTSNFRVALADLVYLLHENMEGLKPSLGD---------INLLFYTTVKVESAGR 1724

  Fly  1715  1714
             Frog  1725  1724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	219/366 (60%)
		Kinesin_assoc	355..498	CDD:465047	44/142 (31%)
		FHA_KIF1	474..574	CDD:438757	39/99 (39%)
		YhaN	<575..>666	CDD:443752	22/95 (23%)
		KIF1B	878..924	CDD:463574	15/71 (21%)
		DUF3694	1199..1347	CDD:463599	26/161 (16%)
		PH_KIFIA_KIFIB	1602..1704	CDD:269939	23/138 (17%)
kif16b	XP_012819297.1	KISc_KIF1A_KIF1B	2..365	CDD:276816	219/366 (60%)
		Kinesin_assoc	364..476	CDD:465047	43/139 (31%)
		FHA_KIF16B	446..562	CDD:438784	44/115 (38%)
		Smc	<600..>1077	CDD:440809	100/581 (17%)