DRSC/TRiP Functional Genomics Resources

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Protein Alignment unc-104 and kif13a

DIOPT Version :9

Sequence 1:NP_611155.3 Gene:unc-104 / 36876 FlyBaseID:FBgn0267002 Length:1739 Species:Drosophila melanogaster
Sequence 2:XP_009291008.1 Gene:kif13a / 100331282 ZFINID:ZDB-GENE-090901-1 Length:1937 Species:Danio rerio


Alignment Length:2012 Identity:567/2012 - (28%)
Similarity:857/2012 - (42%) Gaps:620/2012 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKR----FNFDYSYWSHDH 62
            :.|||||||||.|.|||...:||::||....|.:..|  |.|.....::    |.||:.:||.|.
Zfish     4 TKVKVAVRVRPMNRREIELNTKCVVEMEDNQTVLHPP--PSNAKGESRKQPKVFAFDHCFWSMDE 66

  Fly    63 HD-ADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDL 126
            .: ..::.|.:|:|.:||.:||::|.|||.|||||||||:|||::|||..:  |.|:||.:|..|
Zfish    67 SNIPKYAGQEVVFKCLGEGILQNAFQGYNACIFAYGQTGSGKSFSMMGSGD--QPGLIPRLCCSL 129

  Fly   127 FTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPK-NKGNLRVREHPLLGPYVEDLSKLAVTDYQ 190
            |.|:...::|...:.|||||||||.|:|||||:|| ::.:|:||||.:|||||:.||:||||.::
Zfish   130 FERVSTQQSDSNSFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGLSQLAVTSFE 194

  Fly   191 DIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERA 255
            ||..|:.||||:||||||||||.||||||||::..||..:||.:..:.||||||||||||||||.
Zfish   195 DIESLMSEGNKSRTVAATNMNEESSRSHAVFSVILTQTLYDLQSGNSGEKVSKISLVDLAGSERV 259

  Fly   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGNS 320
            ..|||.|.|||||:||||||||||.||||||:.::.|...|   |:|||||.|||||::||||||
Zfish   260 SKTGAAGERLKEGSNINKSLTTLGCVISALADQSAGKSRNK---FVPYRDSVLTWLLKDNLGGNS 321

  Fly   321 KTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGI 385
            ||||||.||||..||:|||||||||||||:||..||||||.||::||||:||::|||        
Zfish   322 KTAMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELREEVEKLR-------- 378

  Fly   386 EVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQREA 450
                 ::|:::..:|:|...            ::||.|||||.|:..||||||::||||..:|:.
Zfish   379 -----EQLSQAESLKAPELQ------------EKLQESEKLIQEMTVTWEEKLRKTEEIAQERQK 426

  Fly   451 VFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLS 515
            ....||::::..||.||    :....|||||.||.|:|.|:||:|:. ||:|   |:..|||||.
Zfish   427 QLESMGISLESSGIKVG----EDKSFLVNLNADPALNELLVYYLKDH-TRVG---ADTTQDIQLF 483

  Fly   516 GSHILKEHCTFE-NKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQAR 579
            |..|..|||..| ..:..|||.|..:|...|||..:.....:..|.|::.|.||.||...|.:.|
Zfish   484 GIGIQSEHCVLEVTADGDVTLTPAHNARTCVNGMMVYSKVHVWHGDRILWGNNHFFRVNLPNRKR 548

  Fly   580 E------------LRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEMKKRLDNLE 632
            .            :...:||.:||.:|      |...:.|||.|::.| .:.....|:..:..||
Zfish   549 RKDLDRGSPRESFIEADVETASEASSE------QDYSYEFAQMEVMMK-ALGNNDPMQNAVQALE 606

  Fly   633 EQYKREKLQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNPMYESC 697
            :||..||..|   .||||..||..:.:|::|:..:..|.....||:..:.|....::|....|  
Zfish   607 KQYVEEKRLA---LEEQRLMYERELQSLRQQLTPERNTQHQRLSYNTHNTHSRLRLWTEERDE-- 666

  Fly   698 WTAREAGLAAWAFRKWRYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQFQFTLLTDTLYSPLP 762
                       .||:    ..:.||:.:......::|||.:|.|::|...:|.||       .:|
Zfish   667 -----------LFRQ----SLSRLREQVVRANALVREANFLSEEMQKHTDYQATL-------QIP 709

  Fly   763 PELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNGATHHWSLEKLRYRLELMRQIYNVESPPSS 827
               |:.::...:.....:.|      |::|. .|...|..|::|||..:|..||..|.       
Zfish   710 ---AANLSANRKRGAIVSEP------AIQVR-RKGKGTQVWTIEKLENKLVDMRDHYR------- 757

  Fly   828 MLFDTSGMEALSGWISPPSQHPGQQAQLLPLEPPVESERGRLTLANLIPSRQRLELMREMYHNEA 892
                        .|                       ..|...|.|.:             ||:|
Zfish   758 ------------DW-----------------------REGAQELVNRL-------------HNKA 774

  Fly   893 EMSPTSPDYNVESLTGGDPFYDRFPWFRMVGRSFIYLSNLLYPVPLVHKVAIVNERGDVRGYLRI 957
                            |||||:......::|.:.::|..|.:.|.|.:.|.|::::|:|.|.|.:
Zfish   775 ----------------GDPFYEAQENHNLIGVANVFLECLFHDVRLQYAVPIISQQGEVAGRLHV 823

  Fly   958 AVQPVLDEESIDFNNGVKQSARLVFNEDDAKPKYRALNEKDDVQRYIDNGGLDSKLEELEDVDSG 1022
                    |.:..:..|.:  ||.                         ||.||.          
Zfish   824 --------ELLRVSGAVPE--RLC-------------------------GGDDSS---------- 843

  Fly  1023 RGIDSNSASECHENSEEPGEHLQVGKEFTFRVTVLQATGIGAEYAD-IFCQFNFLHRHEEAFS-- 1084
               :::|.|..::..:..||.:.:.::.|.||.:.:|:|:....:: :|||::|..:.|...:  
Zfish   844 ---ENSSESSGYDFMDNNGEIVHMARKLTCRVRIKEASGLPLHLSNFVFCQYSFWDQSEPTVAPP 905

  Fly  1085 -----TEPVKNSASGAPLGFYHVQNITVPVTKSFIEYLKTQPIMFKIFGH---------YQTHPL 1135
                 |...::......:.|.|.::..|.||:.|:|::....:..:::||         ::||.|
Zfish   906 LVSPDTPTARSHDQEFTVRFNHCRDFVVQVTEEFLEFISDGALAIEVWGHRYTGNGRSVWETHTL 970

  Fly  1136 HKDAKQDFVSRPPPRRMLPPSIPISQPVRSPKFGPLPCAPTSTVLAKHDVLVWFEICELAPNGEY 1200
              .||:        |.:......:|:.:.                      :|..|.||...|||
Zfish   971 --QAKK--------RTLRDRWSEVSRSIE----------------------LWVSIQELNEQGEY 1003

  Fly  1201 VPSVVEHSDDLPCRGLFLLHQGIQRRIRI---TIVHEPTTEV----------------------- 1239
            ....:.::.|....|:|.|.||..||:::   .:.|..|..:                       
Zfish  1004 SSVELHNTKDSSTGGVFQLRQGHSRRLQVCVQPVQHSGTLPLLVEAVLSVSIGCVTARSTKLQRP 1068

  Fly  1240 ------------------------KWKDINELVVGR---------IRNTPESSDEQDEDACVL-- 1269
                                    :|.|  .|:..|         |.|.||.|:|..|....|  
Zfish  1069 LDSYQEEDGDMDSYQEEDLNCVRDRWSD--ALIKRREYLEEQIKIILNKPEKSEEDIEREARLVE 1131

  Fly  1270 ---------SLGLFPGEALEVPG-----------------------------DDR---------- 1286
                     :..|.|..|..:||                             :|.          
Zfish  1132 QWVGLTEERNAVLVPAPASGIPGAPAHWVPPAGMEAHIPVLFLDLNADNLTVNDHLTGPHAAGVN 1196

  Fly  1287 ---------SFYRFE------------AAWDSSLHNSALLNRVSQGGETIYITLSAYLELENCAR 1330
                     ||:...            .:||||:|:|..|||::...|.:|:.:.|.::|   :.
Zfish  1197 SILPKEHGSSFFYLPIIRHSDDEVSAVCSWDSSIHDSIHLNRITAANERVYLIVKAAVQL---SH 1258

  Fly  1331 PA----IITKDLSMVIYGRDARTGPRSLKHLFSGQYRNPEANRL--TGV-YELA--LRRASEAGS 1386
            ||    ::.|.:::.||.:.:.|  :|||...|.:      |.|  .|| ||:.  :.:|||   
Zfish  1259 PACVELLLRKRIAVNIYNKQSFT--QSLKRRMSLK------NMLYSCGVTYEIVSNIPKASE--- 1312

  Fly  1387 PGVQRRQRRVLDTSSTYVRGEENLHGWRPRGDSLIFDHQWELEKLTR--LEE-----VGRMRHLL 1444
               :..:|..|...:.....||...|            :..:||.||  ||.     :.|:|..:
Zfish  1313 ---EPEERETLALMAARGENEETRDG------------ETYIEKYTRGVLEVDNILCLDRLRQAV 1362

  Fly  1445 LLRERLGMD--------TNPNPTTKTEKDVCNLAARAATSPVHMVIPQ-----------SPQTPV 1490
            .::|.|...        :.||....:.   |....|.......:.:.:           :..|||
Zfish  1363 TVKEALSAKGKHIRRSLSTPNVQHSSS---CKSDGRTGCEDEDVKVSEQTTQCDALPDGTEDTPV 1424

  Fly  1491 K---------------------DPQ------QIIP--EREYNQRE--------QDLMLKCLKLVQ 1518
            |                     .||      .::|  |.|..:|.        |..|..|:...:
Zfish  1425 KSRENAGVESPAFFSSAAFKTLSPQTHKFIKSLLPLKEEEKTRRTLEARPLLGQQSMRVCMSGPR 1489

  Fly  1519 GRYTKSEANDTQTQSD--VSPSDEGCADMTVSC-ISSNSMENNKFVIRRRLCSPDRADAPNGWEA 1580
            |...::: ::.::..|  :|.|.....|:|.:. .:::|.|::..:.....||          ..
Zfish  1490 GPRPRAQ-SEGRSAGDIIISGSANHSTDLTHTLPHTADSEEDDPGMDSAFTCS----------NV 1543

  Fly  1581 PAPATQPALPLRLYVPE-----------LE---------------------------EIRVSPV- 1606
            ||..:......:.|:||           ||                           |:..||. 
Zfish  1544 PALGSLELQNFKPYIPEEFANFEIYNASLETQEGALCARSELTSGIGMLSGTRAAEKEVSRSPTA 1608

  Fly  1607 -----------VARKGLLNVL-------------------EHG--------GSGWKKRWVIVRRP 1633
                       .:...|.:||                   |||        .||:....:|..:|
Zfish  1609 SSCTSGYFSHSASNATLSDVLFSGSDSCDQLNIREPTDSQEHGKGCHSSRSASGFCPAQIIPSQP 1673

  Fly  1634 YVFIYRSEKD----PVERAVLNL-----------------ATAHVECSEDQAAMVKIPNTFS 1674
            |.. |.:::|    |..:::|::                 |..|..|..:.|:..|..|..|
Zfish  1674 YSH-YLTDRDCSPSPPRKSMLSISQEFTDFKGADDGVEEDALGHFGCKAESASQDKTQNKSS 1734

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-104NP_611155.3 KISc_KIF1A_KIF1B 2..358 CDD:276816 213/361 (59%)
KISc 3..358 CDD:214526 213/360 (59%)
Kinesin_assoc 355..498 CDD:292801 58/142 (41%)
FHA 475..574 CDD:238017 43/99 (43%)
KIF1B 878..923 CDD:289208 8/44 (18%)
DUF3694 1246..1347 CDD:289256 36/184 (20%)
PH_KIFIA_KIFIB 1602..1704 CDD:269939 24/133 (18%)
PH 1607..1700 CDD:278594 22/116 (19%)
kif13aXP_009291008.1 KISc_KIF1A_KIF1B 5..359 CDD:276816 213/360 (59%)
KISc 6..359 CDD:214526 213/359 (59%)
Kinesin_assoc 356..468 CDD:292801 57/140 (41%)
FHA 448..543 CDD:238017 43/98 (44%)
KIF1B 745..790 CDD:289208 17/115 (15%)
DUF3585 <1098..1142 CDD:304905 10/43 (23%)
DUF3694 <1211..1279 CDD:289256 18/70 (26%)
CAP_GLY 1859..1921 CDD:279625
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D76316at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100247
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2883
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.850

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