DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-104 and kif13bb

DIOPT Version :9

Sequence 1:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster
Sequence 2:	XP_009299747.1	Gene:	kif13bb / 100317281	ZFINID:	ZDB-GENE-090908-5	Length:	2095	Species:	Danio rerio

Alignment Length:	1926	Identity:	557/1926 - (28%)
Similarity:	819/1926 - (42%)	Gaps:	565/1926 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDS---VKRFNFDYSYWSHDHH 63
            |:|||||||||.|.||...::||::||.|..|.:..........||   .|.|.:||.:||.|..
Zfish    10 SNVKVAVRVRPMNRRERDLKTKCVVEMEGNQTILYPASGNLGKGDSRAKPKCFAYDYCFWSMDEA 74

  Fly    64 D-ADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLF 127
            : ..|:.|.:|::.:||.:|..:|.|||.|||||||||:||||||||..|  |.|:||.:|..||
Zfish    75 ETGKFAGQDVVFQCLGESLLDSAFQGYNACIFAYGQTGSGKSYTMMGSSE--QPGLIPRLCSSLF 137

  Fly   128 TRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPK-NKGNLRVREHPLLGPYVEDLSKLAVTDYQD 191
            .|....:.:...::|||||||||.|:|||||:|| ::..|:||||.:|||||:.||:|||:.|:|
Zfish   138 ERSVLEQREGESFTVEVSYMEIYNEKVRDLLDPKGSRQALKVREHNVLGPYVDGLSRLAVSSYKD 202

  Fly   192 IHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERAD 256
            |..|:.||||:||||||||||.||||||||.|..|....|:.|..:.|||||:||||||||||||
Zfish   203 IESLMSEGNKSRTVAATNMNEESSRSHAVFNIILTHTLRDMKTGTSGEKVSKLSLVDLAGSERAD 267

  Fly   257 STGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGNSK 321
            .|||.|.|||||:|||:||||||.|||||||..:.|..:|   |:|||||.|||||:::|||||:
Zfish   268 KTGAAGERLKEGSNINRSLTTLGLVISALAEQGAGKNKSK---FVPYRDSVLTWLLKDSLGGNSR 329

  Fly   322 TAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGIE 386
            |||:||:|||..||:|||||||||||||.|:..||||||.||::||||:||::|||
Zfish   330 TAMVAAVSPAADNYEETLSTLRYADRAKSIINHAVVNEDPNARIIRELREEVEKLR--------- 385

  Fly   387 VQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQREAV 451
                .:|:::..:|:|...            ::|:.|||||.|:..:|||||::||||..:|:..
Zfish   386 ----SQLSEAESMKAPELK------------ERLEESEKLIQEMTVSWEEKLRKTEEIAQERQKQ 434

  Fly   452 FAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLSG 516
            ...:|::::..||.|    ..:...|||||.||.|:|.|:||:||. ||:|:.::   |||||.|
Zfish   435 LESLGISLQSSGIRV----IDEKCFLVNLNADPALNELLVYYLKEH-TRVGSADS---QDIQLCG 491

  Fly   517 SHILKEHCTFENKNST-VTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQARE 580
            ..|..|||..:.|..| |||.|.::|...|||..:.....|..|.|::.|.||.||.:.....|
Zfish   492 LAIQPEHCIIDIKPETGVTLTPKRNARTCVNGAVVSSAIQLHHGDRILWGNNHFFRISVSNVYR- 555

  Fly   581 LRDKIETEN---------EAENEVEKTDTQQVDWNF----AQCELLEKQGIDLKAEMKKRLDNLE 632
                :|.|:         ....:|::......|.:|    ||.|::.| .:.....|:..|.:||
Zfish   556 ----VEDEDGCVMKAGLRSDHLDVDRLSLASSDTSFSFESAQTEVMMK-ALGNNDPMQSVLHSLE 615

  Fly   633 EQYKREKLQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNPMYESC 697
            .:::.||..|   .|.||..||..:..|:|::..:..|.|.:    |:.....|.:..:.:....
Zfish   616 RRHEEEKRSA---LERQRLMYEQELQQLRKRLSSELQTQSSH----PQHHRSSEQLNASALSSQS 673

  Fly   698 ----WTAREAGLAAWAFRKWRYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQFQFTLLTDTLY 758
                ||.....|.:.:.||        ||:.:....:.::||..|:.:|.||.:::.||
Zfish   674 RLRQWTDDREVLMSRSLRK--------LREQIVKANLLVQEAGFIAEDLNKKTEYKVTL------ 724

  Fly   759 SPLPPELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNGATHHWSLEKLRYRLELMRQIYNVES 823
             .:|   |:.:....:.|...:.|      |:||. .|......|:|||:..||..||.:|
Zfish   725 -QIP---AANLNANRKRDTVLSEP------AIEVR-RKGKGKQIWALEKIENRLVDMRDLY---- 774

  Fly   824 PPSSMLFDTSGMEALSGWISPPSQHPGQQAQLLPLEPPVESERGRLTLANLIPSRQRLELMREMY 888
                           ..|.......|..::                                  |
Zfish   775 ---------------QEWKDYDEDDPAMRS----------------------------------Y 790

  Fly   889 HNEAEMSPTSPDYNVESLTGGDPFYDRFPWFRMVGRSFIYLSNLLYPVPLVHKVAIVNERGDVRG 953
            ...|                 |||:|......::|.:.::||.|||.|.|.:.|.|:|::|:|.|
Zfish   791 FKRA-----------------DPFFDEQENHSLIGVANVFLSCLLYEVKLQYAVPIINQKGEVSG 838

  Fly   954 YLRIAVQPVLDEESIDFNNGVKQSARLVFNEDDAKPKYRALNEKDDVQRYIDNGGLDSKLEELED 1018
            .|.:.|:                  ||                         :|||     |..:
Zfish   839 RLHVEVE------------------RL-------------------------SGGL-----EESE 855

  Fly  1019 VDSGRGIDSNSASECHENSEEPGEHLQVGKEFTFRVTVLQATGIGAEYAD-IFCQFNFLHRHEEA 1082
            .|:|   ||       |||  |...:| .::||..:.||||||:....:: :|||::|..:.|..
Zfish   856 TDTG---DS-------ENS--PESEMQ-ERKFTCMIKVLQATGLPQHLSNFVFCQYHFWDQPEPV 907

  Fly  1083 FSTEPVKNSASGAP-----LGFYHVQNITVPVTKSFIEYLKTQPIMFKIFGHYQTHPLHKDAKQD 1142
            |....|..||:.:.     :.|.:.:.:.|.||:.|.|:|....:..:::||.|.:|....|..|
Zfish   908 FIAPEVGLSAASSREPQSLVVFDNCKTLEVAVTEDFQEFLMEGAVAVEVYGHKQENPRRNLALWD 972

  Fly  1143 F-VSRPPPRRMLPPSIPISQPVRSPKFGPLPCAPTSTVLAKHDVLVWFEICELAPNGEYVPSVVE 1206
            . |.:...|.:......:::.:.                      :|.::.|:...|.:||..|:
Zfish   973 LGVIQAKTRSLRERWSEVTRRLE----------------------LWVQVLEINDTGVFVPVEVQ 1015

  Fly  1207 HSDDLPCRGLFLLHQGIQRRIRI--------------------------------TIVHEPTTEV 1239
            .:.|:...|:|.|.||..||:.:                                |.....|..|
Zfish  1016 PAKDVCTGGIFQLKQGQSRRVHVEVRSVQDSGTLPLIAESVLSISMGNVEVQQARTAKSTDTQRV 1080

  Fly  1240 KWKDIN----------------------ELVVGRIRNTPESSDEQDEDA--------CVLSL--- 1271
            ..||::                      |.:..|::......::.:||.        |.|:|
Zfish  1081 GDKDMDSYQEVDLERLRAKWLTALTQRQEYLDQRLQKLVSKQNKSEEDVESESQLLECRLTLTEE 1145

  Fly  1272 -----------GL--FPGEALEVPG------------------------------------DDRS 1287
                       |:  .|.|.:.|||                                    |...
Zfish  1146 RNSVLVPSAGSGIPGAPAEWVPVPGMETHIPVIFLDLNADDLHDHLSPPLAGGLDAVLKREDKED 1210

  Fly  1288 F------------YRFEAAWDSSLHNSALLNRVSQGGETIYITLSAYLELENCAR-PAIITKDLS 1339
            |            .:.||:||.::|:|..|||.:...:.:|:|:|..:.|.:.|: ..::.|.:.
Zfish  1211 FIDLQIVKHYENEVKAEASWDCTVHDSPELNRATGQDQRVYLTVSTTVLLSHPAQMQLVLRKRIC 1275

  Fly  1340 MVIYGRDA-------RTGPRSLKH----------LFSGQYRNPEANRLTGVYELALRRASEAGSP 1387
            :.:.||..       |...|||.|          ...|..:..|..      |:..|.|:...:|
Zfish  1276 VNLTGRQGFAQSLLKRMSHRSLIHGCGVTFEIVSNIPGDMQGSEDR------EMLARLATSTDNP 1334

  Fly  1388 G------VQRRQRRVLDTSS----------TYVR--------------GEENLH----------- 1411
            |      :::..|.||...:          ..||              ...|:|
Zfish  1335 GADSEAAIEKYLRSVLAVENILTLDRLRQEVSVREHLTDKGKIPKRCLSSPNVHRLSGSKKDLSI 1399

  Fly  1412 ---------GWRPRGD--------------SLIFDHQWE--LEKLTR---------LEEVGRMRH 1442
                     ||..|.|              |.:..|..|  |..|..         :..|.:|..
Zfish  1400 SQDMEDYKGGWDSRQDISVPTSLPKSKSHSSSVQSHNSEPGLSGLAASYFSPVKALVSPVPKMFK 1464

  Fly  1443 LLLLRERLGMDTNPNP----------------------------TTKTEKDVCNLAARAATSPVH 1479
            .||.::....|. |:|                            |...:...||.:..||..|:.
Zfish  1465 SLLSKKDEKKDL-PSPAAFQQNVPRIVVQSVSLEDIGSSGLVCSTPSEDAAQCNQSEPAAFVPIF 1528

  Fly  1480 MVIPQSPQT---------PVKDPQQI--------IPEREYNQREQDLMLKCL--KLVQGRYTKSE 1525
            .|||...:.         ...|.:::        .|..|.::..::::.|.|  ||.......|.
Zfish  1529 PVIPAGVENTKASTIFSETTSDNKRVSLHSHAIETPVSENSENSEEILPKVLPTKLSAEVLPPSV 1593

  Fly  1526 ANDTQ--------TQSDVSPSDEGCADMTVSCISSNSMENNKFVIRRRLCS----------PDRA 1572
            :.:.:        .:.:|.||.. |.|:.....||..:|       ..|||          |...
Zfish  1594 SQEVEKALPLCISQELEVLPSSV-CQDIEEDLPSSTKVE-------EVLCSSISTKVDEDLPSFV 1650

  Fly  1573 DAPNGWEAP---APATQPALPLRLYVPELEEIR---VSPVV 1607
            ...:|...|   :|..:...||.| .||.||.|   |||.|
Zfish  1651 SLKDGGVLPPTVSPVVREDTPLSL-PPEFEEARHSSVSPEV 1690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	212/360 (59%)
		KISc	3..358	CDD:214526	211/359 (59%)
		Kinesin_assoc	355..498	CDD:292801	55/142 (39%)
		FHA	475..574	CDD:238017	45/99 (45%)
		KIF1B	878..923	CDD:289208	6/44 (14%)
		DUF3694	1246..1347	CDD:289256	32/173 (18%)
		PH_KIFIA_KIFIB	1602..1704	CDD:269939	5/9 (56%)
		PH	1607..1700	CDD:278594	1/1 (100%)
kif13bb	XP_009299747.1	KISc_KIF1A_KIF1B	10..366	CDD:276816	212/360 (59%)
		KISc	11..366	CDD:214526	211/359 (59%)
		Kinesin_assoc	363..475	CDD:292801	53/140 (38%)
		FHA	453..550	CDD:238017	45/100 (45%)
		KIF1B	764..809	CDD:289208	13/114 (11%)
		DUF3694	<1224..1282	CDD:289256	16/57 (28%)
		CAP_GLY	1983..2046	CDD:279625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100247
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2883
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850