DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-104 and stard9

DIOPT Version :9

Sequence 1:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster
Sequence 2:	XP_001921905.4	Gene:	stard9 / 100149555	ZFINID:	ZDB-GENE-111111-11	Length:	3594	Species:	Danio rerio

Alignment Length:	1773	Identity:	446/1773 - (25%)
Similarity:	676/1773 - (38%)	Gaps:	581/1773 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVP----------PNTSDSVKRFNFDY 55
            |::||||:||||.|:||.....:..:::......:.|.|:.          .::.:.:..|.|||
Zfish     1 MANVKVAIRVRPLNTRESLDGGRLAVQVEDKVVRVRNVKLEGRLDGRSEGLADSREKLIEFGFDY 65

  Fly    56 SYWSHDHHDADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIP 120
            .|||.|...:::::|..|::|:|..:|..:.:|||||:|||||||:||::||||..:  ..|:.|
Zfish    66 CYWSVDPAASNYASQEEVFQDLGVCVLSGASEGYNVCLFAYGQTGSGKTHTMMGTPD--SIGLTP 128

  Fly   121 MICKDLFTRIQDTETDDLKYSVEVSYMEIYCERVRDLL---NPKNKGNLRVREHPLLGPYVEDLS 182
            .||:.|| |.....:|.....||:|::|||.|||||||   ..|....|||||||..||||:.||
Zfish   129 RICQGLF-RSGVESSDGQSCRVEISFLEIYNERVRDLLRGVEQKKPAPLRVREHPEKGPYVQGLS 192

  Fly   183 KLAVTDYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLV 247
            :..||||:...||::||...|..|||::::.||||||:|||.:||.  .|..||.:|.||||:||
Zfish   193 QHVVTDYKQAVDLLEEGIANRITAATHVHDASSRSHAIFTIQYTQA--ILENNLPSEIVSKINLV 255

  Fly   248 DLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKAD------------- 299
            |||||||||....: .|:.|||||||||.|||.||||||:......:::..:
Zfish   256 DLAGSERADPQYCR-DRITEGANINKSLVTLGIVISALAQNCQMSSSSQSINSMLSEGEGSTVGS 319

  Fly   300 -------------FIPYRDSALTWLLRENLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQI 351
                         |||||||.|||||:::|||||||.|||.:||:..:|:|||||||||..|:.|
Zfish   320 QSSSLSGSGRRHCFIPYRDSVLTWLLKDSLGGNSKTIMIATVSPSSSSYNETLSTLRYAAHARNI 384

  Fly   352 VCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMA 416
            |.|..||||||.:|||||:|||.:|:.:|..  .|:|..         .||:.|..|..|.:::.
Zfish   385 VNKPRVNEDANVRLIRELREEIDRLKSMLLT--FEMQRN---------PSPSLSDERESSFSDIV 438

  Fly   417 VDQLQASEKLIAELNETWEEKLKRTEEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLN 481
            :......|:|..:.:::|.:|           .|:.....|.:.:|  ..||......|||:.|.
Zfish   439 LQNEMKVEQLTKDWSDSWHDK-----------RALLERYNVDINQD--RAGVLIHSLQPHLIALE 490

  Fly   482 EDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLSGSHIL---KEHCTFENKNSTVTLLPHKDAII 543
            .|...:...:|:::||:||:|      ||...|...||:   ...|..|||:..|||.|....|.
Zfish   491 PDVLSTGVTIYHLREGVTRIG------PQGENLEDPHIVLPEGSSCVIENKSGVVTLKPVSGHIC 549

  Fly   544 YVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQARELRDKIETE------NEAENEVEKTDTQQ 602
            .|:.|::.||..|..|:.:.||..|.|||.:|.:|..||::..|.      ..||......|.:.
Zfish   550 MVSEREITEPCRLAQGAVITLGGLHRFRFNHPAEAAVLRERRRTSEGGLVFTSAELNQPMPDARV 614

  Fly   603 VDWNFAQCELLEKQGIDLKAEMKKRLDNLEEQYKREKLQADQQFEEQRKTYEARIDALQKQVEEQ 667
            ..   |.|:  |:.|   ....::||:  |:|:..|.|:.:.|.|::|.  |..::..|.::.:|
Zfish   615 PG---AGCD--ERGG---GTAPRQRLE--EQQWYIECLREEIQMEQKRA--ERDLEREQARLRQQ 667

  Fly   668 SMTMSMYSSYSPEDFHQEEDVYTNPMYESCWTAREAGLAAWAFRKWRYHQFTSLRDDLWGNAIFL 732
                           |.|                        .::|                 .|
Zfish   668 ---------------HNE------------------------IQQW-----------------IL 676

  Fly   733 KEANAISVELKKKVQFQFTLLTDTLYSPLPPELASTVAPVHQE--DEFGAPP-VS----KTLVAV 790
            :|...::...:|          .||.|.:..:|..:|....||  |....|| :|    |.:|..
Zfish   677 QENQRLAAHREK----------TTLESGVQTDLVLSVTSESQEVRDAETVPPSISMGDRKRVVQE 731

  Fly   791 EVTDTKNGATH-----------HWSLEKL---RYRLELMRQIYNVESPPSSMLFDTSGME----- 836
            |:  .|:.|..           |:.|||:   |:.||..|::..:|:.......:||.:|
Zfish   732 EL--LKHHALRRAENRVRRKRLHYQLEKIARKRHLLEAKRELQRLENLHLEGCNETSSLELAYSL 794

  Fly   837 ALSGWISPPSQHPGQQ---AQLLPLEPPVESE--------------------------RGRLTLA 872
            .|.|......:|....   ::|.|...|:.|:                          |.|   :
Zfish   795 KLRGRPMTLRRHSFSADLLSRLYPQHTPIFSQFLKRNKSSDFTYTKWESDECLQDQKIRRR---S 856

  Fly   873 NLIPSRQRLELMREMYHNEAEMSPTSPDYNVESLTGGDPFYDRFPWFRMVGRSFIYLSNLLYPVP 937
            |.:|||          :::...|..|...|:||
Zfish   857 NTMPSR----------YDQGSSSWASFSDNLES-------------------------------- 879

  Fly   938 LVHKVAIVNERGDVRGYLRIAVQPVLDEESIDFNNGVKQSARLVFNEDDAKPKYRALNEKDDVQR 1002
                                   |:.|..|.:.......|.||:..:..:......|:......|
Zfish   880 -----------------------PLKDSSSAEATKAKTASTRLLVKKSTSDQDKHCLDSNTKAVR 921

  Fly  1003 YIDNGGLDSKLEELEDVDSGRGIDSNSASECHENSEEPGEHLQVGKEFTFRVTVLQATGIGAEYA 1067
            .:      ..:.:.:.:..|....|.|.::..:|         :.|.|:..|    ..||....|
Zfish   922 KV------LPVIKQKSLVKGTKSPSQSGNKGLDN---------IRKVFSNSV----GFGIRTALA 967

  Fly  1068 DIFCQ----------FNFLHRHEEAFSTEPVKNSASGAPLGFYHVQNITVPVTKSFIEY------ 1116
            .:|.:          ...:::....|:.:.:||. :|..|...|.|:   |: ||.:.|
Zfish   968 KVFRKPPSGSRGHKSVKSMNKALRKFNEKSIKNK-TGKDLEKIHKQS---PI-KSAMSYESLGRV 1027

  Fly  1117 --LKTQPIMFKIFGHYQTHPLHKDAKQDFVSRPPPRRMLPPSIPISQPVRSPKFGPLPCAPTST- 1178
              ||.|            |..|..:.:                                |.|||
Zfish  1028 GTLKYQ------------HQRHWHSAE--------------------------------ALTSTK 1048

  Fly  1179 --VLAKHDVLVWFEICELAPNGEYVPSVVEHSD------DLPCRGLF---LLHQGIQRRIRITIV 1232
              |..::....|                |||.|      ...|..:|   .|.....|.:...:.
Zfish  1049 QSVEVQNKAAGW----------------VEHGDVEDSNRSSDCESIFSLDSLSSAYARALAEQLQ 1097

  Fly  1233 HEPTTEVKWKDINELVVGRIRNTPESSDEQ-DEDACVLSLGLFPGEALEVPGDDRSFYRFEAAWD 1296
            .|..      |.:|         .||.|.| .:|:.|:                      |.:|.
Zfish  1098 QEEC------DSSE---------AESEDSQMSQDSLVM----------------------ENSWK 1125

  Fly  1297 SSLHNSAL-LNRVSQGGETIYITLSAYLELENCARPAI-------ITKDLSMVIY---------- 1343
            .......| .|:|..     ::|:|.     :|..|:|       |:||:...:|
Zfish  1126 HMTARPMLRFNKVPS-----HLTVST-----SCGSPSISNKLETKISKDVPAEVYWSLNGSQKLK 1180

  Fly  1344 ---GRDARTGPRSLKHLFS----------GQYRNPEANRLTGVYELALRRASEAGSPGVQRRQRR 1395
               |:....||.||..|.|          .:..||.|  ||..:.    ....|.||.:.|....
Zfish  1181 TENGQGMAKGPSSLSFLASESRPCSGASNRETENPLA--LTDAWS----STDAADSPRIIRASGH 1239

  Fly  1396 -------VLDTSSTYVRGEENLHGWRPRGDSLIFDHQWELEK-------LTRLEEVGRMRHLLLL 1446
                   ::::.|..:.|.:|                 :||.       .|:.|......:....
Zfish  1240 FKQDPPTLIESRSLDLIGNKN-----------------DLESQSSPCSDTTQGENATLESNDTSF 1287

  Fly  1447 RERLGMDTNPNPTT--------KTEKDVCNLAARAATSPVHMVIPQSPQT---------PVKDP- 1493
            ...|.:|.:.:..|        ..|||.|.         :|.|...:..:         |..:|
Zfish  1288 ENTLLLDNHESVPTFIPGIQDLTAEKDPCT---------IHTVYDFTDASLDGVACTNKPTAEPL 1343

  Fly  1494 QQIIPEREYNQREQDLMLKCLKLVQGRYTKSEANDTQTQSDVSPSDEGCADMTVSCISSNSMENN 1558
            ..|:.|.        |::.|         .|:..|..|.|.:|           .|...||.:.:
Zfish  1344 NTIVTEA--------LLIDC---------SSKDGDISTSSSIS-----------KCFLVNSTKED 1380

  Fly  1559 KFVIRRRLCSPDRADAPN 1576
                     |..|.|.|:
Zfish  1381 ---------SDIREDNPS 1389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	178/394 (45%)
		KISc	3..358	CDD:214526	178/393 (45%)
		Kinesin_assoc	355..498	CDD:292801	39/142 (27%)
		FHA	475..574	CDD:238017	37/101 (37%)
		KIF1B	878..923	CDD:289208	6/44 (14%)
		DUF3694	1246..1347	CDD:289256	22/122 (18%)
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
		PH	1607..1700	CDD:278594
stard9	XP_001921905.4	Motor_domain	2..391	CDD:277568	178/394 (45%)
		KISc	3..391	CDD:214526	178/393 (45%)
		Kinesin_assoc	390..507	CDD:292801	39/140 (28%)
		FHA	486..580	CDD:238017	35/99 (35%)
		YscO	639..780	CDD:284686	39/210 (19%)
		KfrA_N	<3178..3251	CDD:288575
		SRPBCC	3391..3591	CDD:301327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820