Protein Alignment unc-104 and kif1a

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: XP_031758411.1
• Gene: kif1a / 100127546
• XenbaseID: XB-GENE-960470
• Length: 1830
• Species: Xenopus tropicalis
• Alignment Length: 1914
• Identity: 989/1914 - (51%)
• Similarity: 1245/1914 - (65%)
• Gaps: 295/1914 - (15%)

  Fly     2 SSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYWSH-DHHDA 65
            :||||||||||||||||.::|||||:|:|.||.|.|||.|..|.   |.|:|||||||| ...|:
 Frog     4 ASVKVAVRVRPFNSREIGKDSKCIIQMSGNTTTIVNPKQPKETP---KSFSFDYSYWSHTSEEDS 65

  Fly    66 DFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDLFTRI 130
            .::.|..||:|||||||.|:|:|||||||||||||||||||||||||..|:||||.:|:|||:||
 Frog    66 QYAGQRQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPTQQGIIPQLCEDLFSRI 130

  Fly   131 QDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIHDL 195
            .||..|::.||||||||||||||||||||||||||||||||||||||||||||||||.||||.||
 Frog   131 SDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYQDIQDL 195

  Fly   196 IDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERADSTGA 260
            :|.|||||||||||||||||||||||.|.|||||||.....||||||||||||||||||||||||
 Frog   196 MDSGNKARTVAATNMNETSSRSHAVFNIIFTQRRHDADAQTTTEKVSKISLVDLAGSERADSTGA 260

  Fly   261 KGTRLKEGANINKSLTTLGKVISALAEVAS---KKKNTKKADFIPYRDSALTWLLRENLGGNSKT 322
            |||||||||||||||||||||||||||:.|   |.|..||.||||||||.|||||||||||||:|
 Frog   261 KGTRLKEGANINKSLTTLGKVISALAEMDSGTNKNKKKKKNDFIPYRDSVLTWLLRENLGGNSRT 325

  Fly   323 AMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGIE- 386
            ||:||:|||||||||||||||||||||||.|.||:|||.|.:||||||:|:.:|||||.|:|:.
 Frog   326 AMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNRLIRELKDEVARLRDLLGAQGLSD 390

  Fly   387 -------VQEEDELTKS-------TVIK-----SPTKS----RNRNGSTT------------EMA 416
                   |...:.|.|.       |.:.     ||:.|    .:|..|.|            |.|
 Frog   391 IIDNVCPVDNGNVLHKRHAADNLFTAVNALTGMSPSSSMSGLSSRAASVTSLHERLAFTPGSEEA 455

  Fly   417 VDQLQASEKLIAELNETWEEKLKRTEEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLN 481
            :::|:.:||:||||||||||||:|||.||:.|||:.||||||::|||.|:|||||||||||||||
 Frog   456 IERLKETEKIIAELNETWEEKLRRTEAIRMDREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLN 520

  Fly   482 EDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLSGSHILKEHCTFENK-----NSTVTLLPHKDA 541
            |||.:|||||||||:|:||:|..:|.:.|||.|||..|..|||.|.:.     :..|||.|...|
 Frog   521 EDPLMSECLLYYIKDGITRVGREDATMRQDIVLSGHFIRDEHCIFRSDVLACGSVVVTLEPCDGA 585

  Fly   542 IIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQARELRDKIETENEAENEVEKTDTQQVDWN 606
            ..||||:||.:|.:|::|:|:|:||:|||||.:|||||:.|::        ....:|.::.|||.
 Frog   586 DTYVNGKKLTDPCILRSGNRIIMGKSHVFRFNHPEQARQERER--------TPCAETPSEPVDWA 642

  Fly   607 FAQCELLEKQGIDLKAEMKKRLDNLEEQYKREKLQADQQFEEQRKTYEARIDALQKQVEEQSMTM 671
            |||.|||||||||:|.||.:||..||:||::|:.:|:...|:||..||:|::|||:|::.:..|
 Frog   643 FAQRELLEKQGIDMKQEMDQRLQELEDQYRKEREEANYLLEQQRLDYESRLEALQRQMDSRYFT- 706

  Fly   672 SMYSSYSPEDFHQEEDVYTNPMYESCWTAREAGLAAWAFRKWRYHQFTSLRDDLWGNAIFLKEAN 736
                     :.::||:   .|..|..||.:|..||.||||||:::|||||||.||||||||||||
 Frog   707 ---------EVNEEEE---EPEDEVQWTEQEYDLALWAFRKWKWYQFTSLRDQLWGNAIFLKEAN 759

  Fly   737 AISVELKKKVQFQFTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNGATH 801
            ||||||||||||||.||||||||||||:|....|...:|..    |..:|:|||||.|.||||||
 Frog   760 AISVELKKKVQFQFVLLTDTLYSPLPPDLLPPDAHTEREKR----PFPRTIVAVEVQDQKNGATH 820

  Fly   802 HWSLEKLRYRLELMRQIYN--VESPP---------------------------SSMLFDTSGMEA 837
            :|:|||||.||::||::|:  .|.|.                           ||.||.|...|:
 Frog   821 YWTLEKLRQRLDMMREMYDRAAELPSGLTEDCDNVVTGGDPFYDRFPWFRLVGSSPLFTTCMSES 885

  Fly   838 LSGWI-SPPSQHPGQQAQLLPLEPPVESERGRLTLANLIPSRQRLELMREMYHNEAEMSPTSPDY 901
            ::... ||....||.:..    ||..:.|.                  .:::.::.| ....|..
 Frog   886 MAEITPSPTLSSPGSEGP----EPASQLEE------------------EDIFQDDEE-EDDGPQE 927

  Fly   902 NVESLTGGDPFYDRFPWFRMVGRSFIYLSNLLYPVPLVHKVAIVNERGDVRGYLRIAVQPV-LDE 965
            :.......|||:||.|.|.:|||:|:|||||||.|||||:||||:|:|:|:|:||:|||.: .||
 Frog   928 HPCCAVRSDPFHDRSPLFSVVGRAFVYLSNLLYSVPLVHRVAIVSEKGEVKGFLRVAVQAISADE 992

  Fly   966 ESIDFNNGVKQS--ARLVFNEDDAKPKYRALNEKDDVQRYIDNGGLDSKLEELEDVDSGRGIDSN 1028
            |:.|:.:||:||  |::.| :|....|::|     :....:...|  :..|||..|:.|:|.:.:
 Frog   993 EAPDYGSGVRQSGTAKISF-DDQHFQKFQA-----ETCPGMTRSG--TSQEELRIVEGGQGQNPD 1049

  Fly  1029 ---SASECHEN---------------------SEEPGEHLQVGKEFTFRVTVLQATGIGAEYADI 1069
               ||.|.:.|                     |:..|..|::|..||||||||||:.|..|||||
 Frog  1050 SCPSADEVNNNTCAASLQSSLLDSPTKPPFDLSDTMGHPLKLGSIFTFRVTVLQASSIPPEYADI 1114

  Fly  1070 FCQFNFLHRHEEAFSTEPVKNSASGAPLGFYHVQNITVPVTKSFIEYLKTQPIMFKIFGHYQTH- 1133
            ||||||:|||:|||||||:||:..|.||||||||||.|.||:||:||:|:|||:|::|||||.|
 Frog  1115 FCQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTQSFVEYVKSQPIVFEVFGHYQQHP 1179

  Fly  1134 --PLHKDAKQDFVSRPPPRRMLPPSIPISQPV--------RSPKFGPLPCAPTSTVLAKHDVLVW 1188
              ||.||......|   .||:||..:|:|:||        |.|..||..|        |:|::.:
 Frog  1180 FPPLCKDVLSPLRS---SRRLLPRVMPLSKPVPATKLSRQRVPSVGPCHC--------KYDLMAY 1233

  Fly  1189 FEICELAPNGEYVPSVVEHSDDLPCRGLFLLHQGIQRRIRITIVHEPTTEVKWKDINELVVGRIR 1253
            |:||||..||:|:|..|:|...|||.|.|||||||||||.:|:|||...|:||.::.||||||||
 Frog  1234 FQICELEANGDYIPVSVDHGVGLPCHGTFLLHQGIQRRISVTLVHEAGAELKWLEVRELVVGRIR 1298

  Fly  1254 NTPESSDEQDEDACVLSLGLFPGEALEVPGDD-----------------RSFYRFEAAWDSSLHN 1301
            |||| :||...|..:|||.:.........|.|                 |:||.||.|||||:||
 Frog  1299 NTPE-ADESLIDPNILSLNILSAGYRPPEGGDRQFLDSDTPSCQSGRGTRTFYHFEVAWDSSMHN 1362

  Fly  1302 SALLNRVSQGGETIYITLSAYLELENCARPAIITKDLSMVIYGRDAR-TGPRSLKHLF-SGQYRN 1364
            |.|||||:...|.||:|||||:|:|||.:||:||||..||.|.|||: ...||:::|| :|..|.
 Frog  1363 SLLLNRVTPYREKIYMTLSAYVEMENCTQPAVITKDFCMVFYSRDAKLPACRSIRNLFGTGSLRA 1427

  Fly  1365 PE----------------------------ANRLTGVYELALRRASEAGSPGVQRRQRRVLDTSS 1401
            .|                            :||:|||||::|.|.:|..|||:|||:|||||||.
 Frog  1428 SERFSYKLLHYCTRLTCMLMNMRGKVGYAPSNRVTGVYEMSLCRVAETSSPGMQRRRRRVLDTSV 1492

  Fly  1402 TYVRGEENLHGWRPRGDSLIFDHQWELEKLTRLEEVGRMRHLLLLRERLGMDTNPNPTTKTEKDV 1466
            .||||||||.|||||.||||.|||||||||:.|:||.:.||.|||||:|
 Frog  1493 AYVRGEENLAGWRPRSDSLILDHQWELEKLSLLQEVEKTRHYLLLREKL---------------- 1541

  Fly  1467 CNLAARAAT-----SPVHMVIPQSPQTPVKDPQQII----PEREYN------QREQDLMLKCLKL 1516
             ....|.||     ||:..::|.||..   .|.|:.    |..|.|      :|:::|..|||:|
 Frog  1542 -EATLRGATESLTPSPIEEMLPLSPTC---QPLQLTEVGSPRAEENPLETASERQKELAAKCLRL 1602

  Fly  1517 VQGRYTKSEANDTQTQSDVSPSDEGCADMTVSCISSNSMEN---NKF--------VIRRRLCSPD 1570
            :...:.:..   :.:...||.|:...::|:|:.:...|:..   |..        ::..|.|||:
 Frog  1603 LTHTFNREY---SYSHVCVSASESKLSEMSVTLLRDPSLSGLGVNSLTPSSTCPSLVEGRYCSPE 1664

  Fly  1571 RAD--------------APNGWEAPAPATQPALP-LRLYVPELEEIRVSPVVARKGLLNVLEHGG 1620
            .:.              :|.|....:|:.:...| |.|:|||::|:||||:|::||.|:.||...
 Frog  1665 ASPQPISRVFSPERELLSPAGDLLKSPSGELKTPTLNLFVPEIQEVRVSPIVSKKGYLHFLEPHT 1729

  Fly  1621 SGWKKRWVIVRRPYVFIYRSEKDPVERAVLNLATAHVECSEDQAAMVKIPNTFSVVTKHRGYLLQ 1685
            .||.||:|:||||||:||.|::||||||:|||:.||||.||||.||:|.||||:|.|:|||.|||
 Frog  1730 GGWVKRYVVVRRPYVYIYNSDRDPVERAILNLSQAHVEYSEDQQAMLKTPNTFAVCTQHRGILLQ 1794

  Fly  1686 TLGDKEVHDWLYAINPLLAGQIKSRLARR 1714
            ...||::||||||.||||||.|:|:|:||
 Frog  1795 ASNDKDMHDWLYAFNPLLAGSIRSKLSRR 1823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	287/359 (80%)
		Kinesin_assoc	355..498	CDD:465047	92/178 (52%)
		FHA_KIF1	474..574	CDD:438757	59/104 (57%)
		YhaN	<575..>666	CDD:443752	43/90 (48%)
		KIF1B	878..924	CDD:463574	10/45 (22%)
		DUF3694	1199..1347	CDD:463599	86/164 (52%)
		PH_KIFIA_KIFIB	1602..1704	CDD:269939	67/101 (66%)
kif1a	XP_031758411.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	287/359 (80%)
		Kinesin_assoc	358..537	CDD:465047	92/178 (52%)
		FHA_KIF1A	513..627	CDD:438778	64/113 (57%)
		KIF1B	827..874	CDD:463574	9/46 (20%)
		DUF3694	1244..1408	CDD:463599	86/164 (52%)
		PH_KIFIA_KIFIB	1711..1813	CDD:269939	67/101 (66%)