Protein Alignment unc-104 and kif3b

DIOPT Version :10

• Sequence 1: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Sequence 2: NP_001093615.1
• Gene: kif3b / 100101641
• ZFINID: ZDB-GENE-050119-3
• Length: 775
• Species: Danio rerio
• Alignment Length: 723
• Identity: 218/723 - (30%)
• Similarity: 351/723 - (48%)
• Gaps: 146/723 - (20%)

  Fly     3 SVKVAVRVRPFNSRE-IARESKCI-IEMAGATTAITNPKVPPNTSDSVKRFNFDYSY-WSHDHHD 64
            ||||.||.||.|.:| :|..::.: :::.....|:.||: ..::.:..|.|.||..| |:
Zfish     9 SVKVVVRCRPMNEKERVANFNRVVSVDVKLGQVAVCNPR-GASSHEHPKVFTFDSVYDWN----- 67

  Fly    65 ADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMG-RQEEQQEGIIPMICKDLFT 128
               |.|..:|.:....::.....|:|..||||||||.||:|||.| |.:.::.|:||...:.:||
Zfish    68 ---SKQMELYDETFRPLVDSVLFGFNGTIFAYGQTGTGKTYTMEGVRNDPERRGVIPNSFEHIFT 129

  Fly   129 RIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQDIH 193
            .|..::..  :|.|..||:|||.|.:||||:......|.::|.|..|.||:|||.......::|.
Zfish   130 HISCSQNQ--QYLVRASYLEIYQEEIRDLLSKDQARRLELKERPDTGVYVKDLSSFVTKSVREIE 192

  Fly   194 DLIDEGNKARTVAATNMNETSSRSHAVF--TIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERAD 256
            .:::.||:.|:|.||||||.||||||:|  ||..::...|...::   :|.|::|||||||||..
Zfish   193 HVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSELGPDGENHI---RVGKLNLVDLAGSERQT 254

  Fly   257 STGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGNSK 321
            .|||:|.||||...||.||:.||.|||||.:        .::..||||||.||.||:::||||::
Zfish   255 KTGAQGERLKEATKINLSLSALGNVISALVD--------GRSTHIPYRDSKLTRLLQDSLGGNAR 311

  Fly   322 TAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLK----- 381
            |.|:|.|.||..|.:|||:|||||:|||.|..|..||||....|:||.:|||.:|::.|:
Zfish   312 TVMVANIGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKEQLEKRSGR 376

  Fly   382 ----------AEGIEVQE--EDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELNETW 434
                      .||.|..|  |||           :..:.:....|..||    ::|.||:.   |
Zfish   377 KRRRRRRRRVGEGGEEFEDGEDE-----------EDDDDDDEDEEEGVD----ADKNIADY---W 423

  Fly   435 EEKLKRTEEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLT 499
            .|:.::.|:   :|.|:..:..:..:|.
Zfish   424 HEQQEKLEK---ERRAIMEDHSLVAEEK------------------------------------- 448

  Fly   500 RLGTHEANVPQDIQLSGSHILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVIL 564
                             ..:|||      |...:|.| ||:.    ...:::..:|....|::::
Zfish   449 -----------------QRLLKE------KERKMTDL-HKEK----EASEMLTAKVKAMESKLLV 485

  Fly   565 GKNHVFRFTNPEQ------ARELRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAE 623
            |..::...||.:|      .:|:.::...|.|.:.|:|..|.:.::.......|  :|.:|:|.:
Zfish   486 GGKNIVDHTNEQQKVLELKRQEIAEQKRREREMKQEMECRDEETLELKETYSSL--QQEVDIKTK 548

  Fly   624 MKKRLDNLEEQYKREKLQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPED------- 681
            ..|:|.:..:..|.|...|..:..:.|:..|...:.|.::::.:.:.:..:.....::
Zfish   549 KLKKLFSKLQSVKSEIQDAQDEHVKYRQELEQTQNELTRELKLKHLIIENFIPMEEKNKIVTRAT 613

  Fly   682 FHQEEDVY 689
            |.:|:|::
Zfish   614 FDEEDDLW 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	152/360 (42%)
		Kinesin_assoc	355..498	CDD:465047	31/159 (19%)
		FHA_KIF1	474..574	CDD:438757	11/99 (11%)
		YhaN	<575..>666	CDD:443752	19/96 (20%)
		KIF1B	878..924	CDD:463574
		DUF3694	1199..1347	CDD:463599
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
kif3b	NP_001093615.1	KISc_KIF3	15..341	CDD:276822	145/347 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	372..419		11/61 (18%)
		Mplasa_alph_rch	<425..>611	CDD:275316	37/255 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	716..775