DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15617 and Grip2

DIOPT Version :9

Sequence 1:	NP_611151.1	Gene:	CG15617 / 36871	FlyBaseID:	FBgn0034151	Length:	222	Species:	Drosophila melanogaster
Sequence 2:	NP_612544.2	Gene:	Grip2 / 171571	RGDID:	621668	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	272	Identity:	56/272 - (20%)
Similarity:	88/272 - (32%)	Gaps:	94/272 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KIRVPKYDSDAFDNVAYELQMTYTLETDCRIMSFYDAMWGMEVTGGIDQFEPLTIVNVSPTGLAK 69
            |:::.| |.|..|.......::||:|     :..|....|:.::|..:.|:|:.|..::..|||:
  Rat   636 KLKIRK-DEDNSDEQESSGAVSYTVE-----LKRYGGPLGITISGTEEPFDPIIISGLTKRGLAE 694

  Fly    70 R-GGMRVGDEITQINDVPALEMTFNEALQMFRKNSRYVRVYVRGDDDAP--------------GE 119
            | |.:.|||.|..||.|.......:||:.:.:.....|.:.::...|.|              .:
  Rat   695 RTGAIHVGDRILAINSVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRQSGSLSEASDVD 759

  Fly   120 ED-------WTCDCWFKPRKP--------WR--------------------RDFTPIQWTFPWND 149
            ||       ......|.|..|        |.                    |..||.:|
  Rat   760 EDPPEALKGGLLTTHFSPAVPSVDSAVESWGSSATEGGFGGSGSYTPQVAVRSVTPQEW------ 818

  Fly   150 RRKPVYKESNCFMVPSKMEEKIRARRAATSAVHKKDELAPHTRSLTPTPR----PKNQPGPNLLE 210
                                  |:.|..:|    ...|.|...|.||.|.    |:.:.|.  .|
  Rat   819 ----------------------RSSRLKSS----PPPLEPRRTSYTPGPTDESFPEEEEGD--WE 855

  Fly   211 TVLRPRGPPPRD 222
            ..:.|...|.|:
  Rat   856 PPMSPAPGPARE 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15617	NP_611151.1	PDZ_signaling	30..111	CDD:238492	22/81 (27%)
Grip2	NP_612544.2	PDZ_signaling	51..133	CDD:238492
		PDZ_signaling	153..236	CDD:238492
		PDZ_signaling	251..334	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..450
		PDZ_signaling	456..544	CDD:238492
		PDZ_signaling	557..640	CDD:238492	1/3 (33%)
		PDZ_signaling	657..737	CDD:238492	24/84 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	745..769		2/23 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	786..863		18/110 (16%)
		PDZ_signaling	941..1020	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810