DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Picot and Slc17a7

DIOPT Version :9

Sequence 1:	NP_725600.1	Gene:	Picot / 36865	FlyBaseID:	FBgn0024315	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_892038.2	Gene:	Slc17a7 / 72961	MGIID:	1920211	Length:	560	Species:	Mus musculus

Alignment Length:	537	Identity:	174/537 - (32%)
Similarity:	270/537 - (50%)	Gaps:	65/537 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPFRRSSLNHRHRDGHVLVWNQRNLHESLEQQPQ--------------------------RCFA- 38
            |.||:...  |...|..|    ..||..||::.:                          .||.
Mouse     1 MEFRQEEF--RKLAGRAL----GRLHRLLEKRQEGAETLELSADGRPVTTHTRDPPVVDCTCFGL 59

  Fly    39 -TRYFVTFMLFLGMANAYVMRTNMSVAIVAMVNHTAIKSGEAEEYDDECGDRDIPIDDSQDGEFA 102
             .||.:..|..||...::.:|.|:.||||:|||::....|         |...:     |..:|.
Mouse    60 PRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRG---------GHVVV-----QKAQFN 110

  Fly   103 WSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARGGGVWGLCA 167
            |.....|.|..|||:||::||||.|.:.:|:.:.|..|:.::..|....|:|.|||   |...|.
Mouse   111 WDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAAR---VHYGCV 172

  Fly   168 --VRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDGGW 230
              ||.:|||.||...|..|.:.:||.||.||||:....:.|:..|.:::|||:|:|.:|   .||
Mouse   173 IFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQY---SGW 234

  Fly   231 PSIFYVFGIVGTVWSIAFLIFVHEDPSSHPTIDEREKKYINDSLWGTDVVKSP----PIPFKAII 291
            .|:|||:|..|..|.:.:|:..:|.|:.||:|.|.|:|||.|::..:..:.:|    ..|::...
Mouse   235 SSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERKYIEDAIGESAKLMNPVTKFNTPWRRFF 299

  Fly   292 KSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADW 356
            .|:|.|||:.|:...::.:..|:...|.|.::|..|.:...||:|:||:|.|.:.......:||:
Mouse   300 TSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADF 364

  Fly   357 MISSKRFSHTATRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINHLD 421
            :.|....|.|..|||:| .|.:|....|:........:.:.::.|.:.||.:|...|||.:||||
Mouse   365 LRSRHIMSTTNVRKLMN-CGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLD 428

  Fly   422 LTPRFAGFLMSITNCSANLAGLLAPIAAGHLISDPSKPMMGQWQIVFFIAAFVYIICGTFYNIFG 486
            :.||:|..||.|:|....|:|::.||..|.:....::.   :||.||.||:.|:.....||.:|.
Mouse   429 IAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTRE---EWQYVFLIASLVHYGGVIFYGVFA 490

  Fly   487 SGERQYWDNPED-DEQK 502
            |||:|.|..||: .|:|
Mouse   491 SGEKQPWAEPEEMSEEK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Picot	NP_725600.1	2A0114euk	41..501	CDD:129972	159/466 (34%)
Picot	NP_725600.1	MFS	100..485	CDD:119392	135/390 (35%)
Slc17a7	NP_892038.2	MFS_SLC17A6_7_8_VGluT	66..490	CDD:340940	150/447 (34%)
Slc17a7	NP_892038.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..560		5/11 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838690
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.650