DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Picot and Slc37a2

DIOPT Version :9

Sequence 1:	NP_725600.1	Gene:	Picot / 36865	FlyBaseID:	FBgn0024315	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001139432.1	Gene:	Slc37a2 / 56857	MGIID:	1929693	Length:	506	Species:	Mus musculus

Alignment Length:	515	Identity:	115/515 - (22%)
Similarity:	187/515 - (36%)	Gaps:	126/515 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RYFVTFMLFLGMANAYVMRTNMSVAIVAMVNHTAIKSGEAEEYDDECGDRDIPIDDSQD-GEFAW 103
            |.|:..:.||..|..::.|..:|:          :||    .....|.:...|::|:.| .:..|
Mouse    22 RGFILLLTFLIYACYHMSRKPISI----------VKS----RLHQNCSEMVRPVNDTHDLNDTTW 72

  Fly   104 SS----------ALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAAR 158
            .|          .|.|.:.::|...|.|.....||..::.....:|..||:::.:|..|.
Mouse    73 CSWSPFDKDDYKELLGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLF----- 132

  Fly   159 GGG-------VWGLCAVRFIQGL----GEGPIVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTI 212
            |.|       :|....::...||    |...:|.|    :..|....:|..:.....:....|.|
Mouse   133 GLGYFWNIHMLWYFVLIQICNGLVQTTGWPSVVTC----VGNWFGKGKRGFIMGIWNSHTSVGNI 193

  Fly   213 ISMPLSGLLAEYGFDGGWPSIFYVFGIVGTVWSI---AFLIFVHED-----PSSHPTIDEREKKY 269
                |..|:|....:..|...|.|.||:..:..:   .|||...||     |..|   |:.||:.
Mouse   194 ----LGSLIAGVWVNQHWGLSFIVPGIITAIMGVITFLFLIEYPEDVDCTPPRHH---DDPEKEQ 251

  Fly   270 INDSLWGTDVVKSP-----------------------PIPFKAIIKSLP-----FYAILFAHMGH 306
            .|..    |.|.||                       .|.|...:: :|     ...:|||.:
Mouse   252 DNPE----DPVNSPYSSRESNVDIAASSSKEQGPEPEAISFLGALR-IPGVIEFSLCLLFAKL-- 309

  Fly   307 NYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADWMISSKRFSHTATRKL 371
             ..| |.:..||.|:..|..||.|..|.||:|..:...:..:...:::|:..|.   :.|....|
Mouse   310 -VSY-TFLYWLPLYIFNVAHFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTNSR---ATTCCIML 369

  Fly   372 I---------NSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINHLDLTPRFA 427
            |         |.|||.|...:::.....|.......|::|..|..:.|.:...|.|...|:.
Mouse   370 ILAAPMMFLYNYIGQNGITSSIVMLIICGVLVNGPYALITTAVSADLGTHESLKGNAKALST--- 431

  Fly   428 GFLMSITNCSANLAGLLAPIAAGHLISDPSKPMMGQWQIVFF--IAAFV---YIICGTFY 482
              :.:|.:.:.::...|.|:.|| |||...      |..||:  |:|.|   .::|...|
Mouse   432 --VTAIIDGTGSIGAALGPLLAG-LISPTG------WNNVFYMLISADVLACLLLCRLVY 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Picot	NP_725600.1	2A0114euk	41..501	CDD:129972	114/514 (22%)
Picot	NP_725600.1	MFS	100..485	CDD:119392	102/454 (22%)
Slc37a2	NP_001139432.1	UhpC	25..478	CDD:332119	111/506 (22%)
Slc37a2	NP_001139432.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..266		10/32 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838825
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840