DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Picot and NaPi-T

DIOPT Version :9

Sequence 1:	NP_725600.1	Gene:	Picot / 36865	FlyBaseID:	FBgn0024315	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001260981.1	Gene:	NaPi-T / 36651	FlyBaseID:	FBgn0016684	Length:	524	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	157/526 - (29%)
Similarity:	254/526 - (48%)	Gaps:	66/526 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RYFVTFMLFLGMANAYVMRTNMSVAIVAMV-NHTAIKSGEAEEYDD------ECGDR-------- 89
            |..:.:|.|:|....|::|.|:::.||.|: ...||.|.|..|...      |..:|
  Fly     7 RTVLWYMTFIGFIVNYMIRINLNITIVDMIAGKGAITSNETHENSTDLAALAEMNERFSLERWFL 71

  Fly    90 ---DIPIDDSQDGEFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAF 151
               :||.:  ::| |.|:...||.:|.|||:.:...|||.||||.|||:....|:...|.....|
  Fly    72 DWANIPYE--KNG-FHWNEKQQGALLGSFFWAHWTLQIPGGILATKYGTKLVFGWSNGIGVFCCF 133

  Fly   152 LVPVAARGGGVW---GLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTII 213
            |:|:.:    .|   ||..:|..||...|...|..|.:.||||||||||:..:| |.|:..|..:
  Fly   134 LIPIVS----YWSYTGLIILRVFQGWITGLAWPSMHVLTAKWIPPNERSKFVSA-YLGSSVGVAL 193

  Fly   214 SMPLSGLLAEYGFDGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSHPTIDEREKKYINDSLWGTD 278
            ..|:.|.:.::   ..|..::|:.|||||:|.||:...|.:.|:.||.|.:.|:|:|..||..:.
  Fly   194 FYPIFGYIIDW---TRWEWVYYICGIVGTLWFIAWQFLVFDSPAEHPRIADSERKFIEKSLGASI 255

  Fly   279 VVKSPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAM 343
            .....|.|:|||..|.|.:..:.|..|..:|..||||..|||.:.:..:::::.|.||.||:|..
  Fly   256 QGSKGPTPWKAIATSRPVWLNVVAQWGGIWGLFTLMTHAPTYFRLIHHWNIRATGFLSGLPHLMR 320

  Fly   344 WLFSMFISVVADWMISSKRFSHTATRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLN 408
            .||:...|:.||:::.:.:.|.|..|||...|.....|:.::|.:|.|.:....:.::|:...|:
  Fly   321 MLFAYVFSIFADYLLRTDKMSRTNVRKLATFICCGTKGLIVLALAYFGYNATAAIVLVTVATMLH 385

  Fly   409 GGIYSGFKINHLDLTPRFAGFLMSITNCSANLAGLLAPIAAGHLISDPSKPMMGQWQIVFFIAAF 473
            |.:.||...:.:||:|.:||.::.::.....:.|.::|...|.|..  :...:..|:.||.:.:.
  Fly   386 GAVSSGPLASMVDLSPNYAGIVLGVSGMIGGMPGFISPFIVGQLTH--NNQTIDAWKNVFLLTSL 448

  Fly   474 VYIICGTFYNIFGSGERQYW--------------------DNPEDDEQKP------------ALQ 506
            :....|..|.:|...:.|.|                    |..:::|:||            |.|
  Fly   449 MLTGSGILYVLFSESKLQPWNSGCHQLPDSGLKELQNLGRDQDDEEEKKPLKSDHDKETPIVAEQ 513

  Fly   507 TTVTTS 512
            .|.|.|
  Fly   514 ETKTKS 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Picot	NP_725600.1	2A0114euk	41..501	CDD:129972	148/500 (30%)
Picot	NP_725600.1	MFS	100..485	CDD:119392	125/387 (32%)
NaPi-T	NP_001260981.1	2A0114euk	1..474	CDD:129972	148/479 (31%)
NaPi-T	NP_001260981.1	MFS	76..460	CDD:119392	128/396 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I288
eggNOG	1	0.900	-	-		E1_KOG2532
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
	8	7.960